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In recent years, a large and growing body of literature has investigated ferroptosis. Since ferroptosis is associated with various physiological activities and regulated by a variety of cellular metabolism and mitochondrial activity, ferroptosis has been closely related to the occurrence and development of many diseases, including cancer, aging, neurodegenerative diseases, ischemia\u2013reperfusion injury and other pathological cell death. The regulation of ferroptosis mainly focuses on three pathways: system Xc\u2212\/GPX4 axis, lipid peroxidation and iron metabolism. The genes involved in these processes were divided into driver, suppressor and marker. Importantly, small molecules or drugs that mediate the expression of these genes are often good treatments in the clinic. Herein, a newly developed database, named \u2018FERREG\u2019, is documented to (i) providing the data of ferroptosis-related regulation of diseases occurrence, progression and drug response; (ii) explicitly describing the molecular mechanisms underlying each regulation; and (iii) fully referencing the collected data by cross-linking them to available databases. Collectively, FERREG contains 51 targets, 718 regulators, 445 ferroptosis-related drugs and 158 ferroptosis-related disease responses. FERREG can be accessed at https:\/\/idrblab.org\/ferreg\/.<\/jats:p>","DOI":"10.1093\/bib\/bbae223","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T09:29:06Z","timestamp":1715678946000},"source":"Crossref","is-referenced-by-count":5,"title":["FERREG: ferroptosis-based regulation of disease occurrence, progression and therapeutic response"],"prefix":"10.1093","volume":"25","author":[{"given":"Yuan","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Zhejiang University School of Medicine, Zhejiang University , The Second Affiliated Hospital, , Hangzhou, 310058 , China"}]},{"given":"Mengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]},{"given":"Fengyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]},{"given":"Jiayi","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy , The First Affiliated Hospital,"},{"name":"Zhejiang University School of Medicine , The First Affiliated Hospital,"}]},{"given":"Yintao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Zhejiang University School of Medicine, Zhejiang University , The Second Affiliated Hospital, , Hangzhou, 310058 , China"}]},{"given":"Xuheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Zhejiang University School of Medicine, Zhejiang University , The Second Affiliated Hospital, , Hangzhou, 310058 , China"}]},{"given":"Xiuna","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Zhejiang University School of Medicine, Zhejiang University , The Second Affiliated Hospital, , Hangzhou, 310058 , China"}]},{"given":"Ziheng","family":"Ni","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]},{"given":"Qun","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory, The Affiliated Hospital of Hangzhou Normal University , Hangzhou, 311121 , China"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Zhejiang University School of Medicine, Zhejiang University , The Second Affiliated Hospital, , Hangzhou, 310058 , China"},{"name":"Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare , Hangzhou, 330110 , China"}]},{"given":"Shuiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"},{"name":"Hangzhou Normal University , Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, School of Pharmacy, and Department of Respiratory Medicine of Affiliated Hospital, , Hangzhou, 311121 , China"}]}],"member":"286","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"issue":"5","key":"2024051409033954200_ref1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"issue":"1","key":"2024051409033954200_ref2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct Target 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