{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:47:26Z","timestamp":1773488846667,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED431G 2019\/02"],"award-info":[{"award-number":["ED431G 2019\/02"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["ED481A 2022"],"award-info":[{"award-number":["ED481A 2022"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chimeric antigen receptor (CAR) therapy has emerged as a ground-breaking advancement in cancer treatment, harnessing the power of engineered human immune cells to target and eliminate cancer cells. The escalating interest and investment in CAR therapy in recent years emphasize its profound significance in clinical research, positioning it as a rapidly expanding frontier in the field of personalized cancer therapies. A crucial step in CAR therapy design is choosing the right target as it determines the therapy\u2019s effectiveness, safety and specificity against cancer cells, while sparing healthy tissues. Herein, we propose a suite of tools for the identification and analysis of potential CAR targets leveraging expression data from The Cancer Genome Atlas and Genotype-Tissue Expression Project, which are implemented in CARTAR website. These tools focus on pinpointing tumor-associated antigens, ensuring target selectivity and assessing specificity to avoid off-tumor toxicities and can be used to rationally designing dual CARs. In addition, candidate target expression can be explored in cancer cell lines using the expression data for the Cancer Cell Line Encyclopedia. To our best knowledge, CARTAR is the first website dedicated to the systematic search of suitable candidate targets for CAR therapy. CARTAR is publicly accessible at https:\/\/gmxenomica.github.io\/CARTAR\/.<\/jats:p>","DOI":"10.1093\/bib\/bbae326","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:46:54Z","timestamp":1720442814000},"source":"Crossref","is-referenced-by-count":6,"title":["CARTAR: a comprehensive web tool for identifying potential targets in chimeric antigen receptor therapies using TCGA and GTEx data"],"prefix":"10.1093","volume":"25","author":[{"given":"Miguel","family":"Hernandez-Gamarra","sequence":"first","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"Alba","family":"Salgado-Roo","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"Eduardo","family":"Dominguez","sequence":"additional","affiliation":[{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"Elena Mar\u00eda","family":"Goiricelaya Seco","sequence":"additional","affiliation":[{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"Sara","family":"Veiga-R\u00faa","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"Luc\u00eda F","family":"Pedrera-Garbayo","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"}]},{"given":"\u00c1ngel","family":"Carracedo","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"},{"name":"Fundaci\u00f3n P\u00fablica Galega de Medicina Xen\u00f3mica (FPGMX) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"},{"name":"CB06\/07\/0088, Center for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III , Av. Monforte de Lemos, 28029 Madrid , Spain"}]},{"given":"Catarina","family":"Allegue","sequence":"additional","affiliation":[{"name":"Genomic Medicine Group , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"University of Santiago de Compostela , Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), , Av. Barcelona, 15706 A Coru\u00f1a , Spain"},{"name":"C005, Instituto de Investigaci\u00f3n Sanitaria de Santiago (IDIS) , Traves\u00eda da Choupana, 15706 A Coru\u00f1a , Spain"},{"name":"CB06\/07\/0088, Center for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III , Av. 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