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Our study focuses on the gut microbiota, essential for metabolic, nutritional, and immune functions, which undergoes significant changes with aging. These changes can impair intestinal function, leading to altered microbial diversity and composition that potentially influence health outcomes and disease progression. Using advanced metagenomic sequencing, we explore the potential of personalized probiotic supplements in 297 older adults by analyzing their gut microbiota. We identified distinctive Lactobacillus and Bifidobacterium signatures in the gut microbiota of older adults, revealing probiotic patterns associated with various population characteristics, microbial compositions, cognitive functions, and neuroimaging results. These insights suggest that tailored probiotic supplements, designed to match individual probiotic profile, could offer an innovative method for addressing age-related diseases and functional declines. Our findings enhance the existing evidence base for probiotic use among older adults, highlighting the opportunity to create more targeted and effective probiotic strategies. However, additional research is required to validate our results and further assess the impact of precision probiotics on aging populations. Future studies should employ longitudinal designs and larger cohorts to conclusively demonstrate the benefits of tailored probiotic treatments.<\/jats:p>","DOI":"10.1093\/bib\/bbae351","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:17:12Z","timestamp":1721693832000},"source":"Crossref","is-referenced-by-count":19,"title":["Precision probiotics supplement strategy in aging population based on gut microbiome composition"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-9855","authenticated-orcid":false,"given":"Yi-Fang","family":"Chuang","sequence":"first","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304 , Taiwan"},{"name":"Institute of Public Health, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304 , Taiwan"},{"name":"Department of Psychiatry, Far Eastern Memorial Hospital , No. 21, Sec. 2, Nanya S. Rd., Banqiao Dist., New Taipei City 220216 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1931-0226","authenticated-orcid":false,"given":"Kang-Chen","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-9797","authenticated-orcid":false,"given":"Yin-Yuan","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4035-8065","authenticated-orcid":false,"given":"Ming-Fong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung University , No. 155, Sec. 2, Linong St. Beitou Dist., Taipei City 112304 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4504-5571","authenticated-orcid":false,"given":"Yen-Ling","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Far Eastern Memorial Hospital , No. 21, Sec. 2, Nanya S. Rd., Banqiao Dist., New Taipei City 220216 , Taiwan"},{"name":"Graduate Program in Biomedical Informatics and Graduate Institute of Medicine, Yuan Ze University , No. 135, Yuandong Rd., Zhongli Dist., Taoyuan City 320315 , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University , No. 1, Sec. 4, Roosevelt Rd., Taipei City 106319 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2579-740X","authenticated-orcid":false,"given":"Yi-Chien","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardinal Tien Hospital , No. 362, Zhongzheng Rd., Xindian Dist., New Taipei City 231009 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7831-7855","authenticated-orcid":false,"given":"Chen-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Informatics, National Yang Ming Chiao Tung 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