{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T14:49:31Z","timestamp":1777560571607,"version":"3.51.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20ZR1410800"],"award-info":[{"award-number":["20ZR1410800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["82373371"],"award-info":[{"award-number":["82373371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Major Project of China","award":["2020YFC2008402"],"award-info":[{"award-number":["2020YFC2008402"]}]},{"name":"Program for Professor of Special Appointment"},{"name":"Shanghai Institutions of Higher Learning"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancerous genetic mutations result in a complex and comprehensive post-translational modification (PTM) dynamics, in which protein succinylation is well known for its ability to reprogram cell metabolism and is involved in the malignant evolution. Little is known about the regulatory interactions between succinylation and other PTMs in the PTM network. Here, we developed a conjoint analysis and systematic clustering method to explore the intermodification communications between succinylome and phosphorylome from eight lung cancer patients. We found that the intermodification coorperation in both parallel and series. Besides directly participating in metabolism pathways, some phosphosites out of mitochondria were identified as an upstream regulatory modification directing succinylome dynamics in cancer metabolism reprogramming. Phosphorylated activation of histone deacetylase (HDAC) in lung cancer resulted in the removal of acetylation and favored the occurrence of succinylation modification of mitochondrial proteins. These results suggest a tandem regulation between succinylation and phosphorylation in the PTM network and provide HDAC-related targets for intervening mitochondrial succinylation and cancer metabolism reprogramming.<\/jats:p>","DOI":"10.1093\/bib\/bbae415","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:33:42Z","timestamp":1724459622000},"source":"Crossref","is-referenced-by-count":7,"title":["Conjoint analysis of succinylome and phosphorylome reveals imbalanced HDAC phosphorylation-driven succinylayion dynamic contibutes to lung cancer"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9281-6440","authenticated-orcid":false,"given":"Yifan","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyu","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxia","family":"Jiao","sequence":"additional","affiliation":[{"name":"Shanghai Fifth People's Hospital and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University , 131 Dongan Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Fifth People's Hospital and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University , 131 Dongan Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"},{"name":"Fudan University , Zhongshan Hospital, , 180 Fenglin Road, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"2024082322482134800_ref1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nsmb.1842","article-title":"Post-translational modifications in signal integration","volume":"17","author":"Deribe","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"2024082322482134800_ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrg3356","article-title":"Next-generation proteomics: towards an integrative view of proteome dynamics","volume":"14","author":"Altelaar","year":"2013","journal-title":"Nat Rev 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