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ReCIDE outperforms existing approaches in benchmark and real datasets, particularly excelling in estimating rare cell type proportions. Through exploratory analysis on public bulk data of triple-negative breast cancer (TNBC) patients using ReCIDE, we demonstrate a significant correlation between the prognosis of TNBC patients and the proportions of both T cell and perivascular-like cell subtypes. Built upon this discovery, we develop a prognostic assessment model for TNBC patients. Our contribution presents a novel framework for enhancing deconvolution accuracy, showcasing its effectiveness in medical research.<\/jats:p>","DOI":"10.1093\/bib\/bbae422","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T23:31:06Z","timestamp":1724455866000},"source":"Crossref","is-referenced-by-count":2,"title":["ReCIDE: robust estimation of cell type proportions by integrating single-reference-based deconvolutions"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2050-290X","authenticated-orcid":false,"given":"Minghan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Department of Computational Biology, School of Life Sciences, , 2005 Songhu Road, Yangpu District, Shanghai 200438 , China"},{"name":"Fudan University , Department of Computational Biology, School of Life Sciences, , 2005 Songhu Road, Yangpu District, Shanghai 200438 , China"}]},{"given":"Yuqing","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Department of Computational Biology, School of Life Sciences, , 2005 Songhu Road, Yangpu District, Shanghai 200438 , China"},{"name":"Fudan University , Department of Computational Biology, School of Life Sciences, , 2005 Songhu Road, Yangpu District, Shanghai 200438 , China"}]},{"given":"Yanbo","family":"Gao","sequence":"additional","affiliation":[{"name":"Shanghai SPH Jiaolian Pharmaceutical Technology Company, Limited , Buliding 4, 998 Ha Lei Road, Pudong District, Shanghai 201203 , China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-2682","authenticated-orcid":false,"given":"Weidong","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Department of Computational Biology, School of Life Sciences, , 2005 Songhu Road, Yangpu District, Shanghai 200438 , China"},{"name":"Fudan University , 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