{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:13:36Z","timestamp":1784546016973,"version":"3.55.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470649"],"award-info":[{"award-number":["32470649"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32030020"],"award-info":[{"award-number":["32030020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32288101"],"award-info":[{"award-number":["32288101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2605400"],"award-info":[{"award-number":["2023YFC2605400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sex-biased gene expression differs across human populations; however, the underlying genetic basis and molecular mechanisms remain largely unknown. Here, we explore the influence of ancestry on sex differences in the human transcriptome and its genetic effects on a Eurasian admixed population: Uyghurs living in Xinjiang (XJU), by analyzing whole-genome sequencing data and transcriptome data of 90 XJU and 40 unrelated Han Chinese individuals. We identified 302 sex-biased expressed genes and 174 sex-biased cis-expression quantitative loci (sb-cis-eQTLs) in XJU, which were enriched in innate immune-related functions, indicating sex differences in immunity. Notably, approximately one-quarter of the sb-cis-eQTLs showed a strong correlation with ancestry composition; i.e. populations of similar ancestry tended to show similar patterns of sex-biased gene expression. Our analysis further suggested that genetic admixture induced a moderate degree of sex-biased gene expression. Interestingly, analysis of chromosome interactions revealed that the X chromosome acted on autosomal immunity-associated genes, partially explaining the sex-biased phenotypic differences. Our work extends the knowledge of sex-biased gene expression from the perspective of genetic admixture and bridges the gap in the exploration of sex-biased phenotypes shaped by autosome and X-chromosome interactions. Notably, we demonstrated that sex chromosomes cannot fully explain sex differentiation in immune-related phenotypes.<\/jats:p>","DOI":"10.1093\/bib\/bbae451","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T22:36:39Z","timestamp":1726698999000},"source":"Crossref","is-referenced-by-count":7,"title":["Analysis of sex-biased gene expression in a Eurasian admixed population"],"prefix":"10.1093","volume":"25","author":[{"given":"Shuangshuang","family":"Cheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433 , China"},{"name":"Fudan University , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilin","family":"Ning","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"},{"name":"School of Life Science and Technology, ShanghaiTech University , 393 Middle Huaxia 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Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433 , China"},{"name":"Fudan University , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoji","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 320 Yueyang Road, Xuhui District, Shanghai, 200031 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433, China"},{"name":"Fudan University , Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, , 220 Handan Road, Yangpu District, Shanghai, 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Preclinical Medicine College Xinjiang Medical University , 137 South Liyushan Road, Xincheng District, Urumqi, Xinjiang Uygur Autonomous Region, 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolikun","family":"Mamatyusupu","sequence":"additional","affiliation":[{"name":"College of the Life Sciences and Technology, Xinjiang University , 666 Shengli Road, Tianshan District, Urumqi, Xinjiang Uygur Autonomous Region, 830046, 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