{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:56:52Z","timestamp":1772107012168,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Hospitals Authority Clinical medicine Development","award":["ZLRK202312"],"award-info":[{"award-number":["ZLRK202312"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20358"],"award-info":[{"award-number":["U20A20358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870905"],"award-info":[{"award-number":["81870905"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","award":["2019-I2M-5-029"],"award-info":[{"award-number":["2019-I2M-5-029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ischemic stroke (IS) is a leading cause of adult disability that can severely compromise the quality of life for patients. Accurately predicting the IS functional outcome is crucial for precise risk stratification and effective therapeutic interventions. We developed a predictive model integrating genetic, environmental, and clinical factors using data from 7819 IS patients in the Third China National Stroke Registry. Employing an 80:20 split, we randomly divided the dataset into development and internal validation cohorts. The discrimination and calibration performance of models were evaluated using the area under the receiver operating characteristic curves (AUC) for discrimination and Brier score with calibration curve in the internal validation cohort. We conducted genome-wide association studies (GWAS) in the development cohort, identifying rs11109607 (ANKS1B) as the most significant variant associated with IS functional outcome. We employed principal component analysis to reduce dimensionality on the top 100 significant variants identified by the GWAS, incorporating them as genetic factors in the predictive model. We employed a machine learning algorithm capable of identifying nonlinear relationships to establish predictive models for IS patient functional outcome. The optimal model was the XGBoost model, which outperformed the logistic regression model (AUC 0.818 versus 0.756, P\u2009&amp;lt;\u2009.05) and significantly improved reclassification efficiency. Our study innovatively incorporated genetic, environmental, and clinical factors for predicting the IS functional outcome in East Asian populations, thereby offering novel insights into IS functional outcome.<\/jats:p>","DOI":"10.1093\/bib\/bbae487","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T05:50:12Z","timestamp":1728885012000},"source":"Crossref","is-referenced-by-count":3,"title":["Predicting functional outcome in ischemic stroke patients using genetic, environmental, and clinical factors: a machine learning analysis of population-based prospective cohort study"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8669-7842","authenticated-orcid":false,"given":"Siding","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Changping Laboratory , Yard 28, Science Park Road, Changping District, Beijing 102206 ,","place":["China"]}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Jinfeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Hongqiu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Yanfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Cang","family":"Guo","sequence":"additional","affiliation":[{"name":"Changping Laboratory , Yard 28, Science Park Road, Changping District, Beijing 102206 ,","place":["China"]}]},{"given":"Xia","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Xinying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]},{"given":"Yong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Changping Laboratory , Yard 28, Science Park Road, Changping District, Beijing 102206 ,","place":["China"]},{"name":"Beijing Advanced Innovation Center for Big Data-Based Precision Medicine (Beihang University and Capital Medical University) , No. 37 Xueyuan Road, Haidian District, Beijing 100191 ,","place":["China"]}]},{"given":"Yongjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"China National Clinical Research Center for Neurological Diseases , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Capital Medical University , Beijing Tiantan Hospital, , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Changping Laboratory , Yard 28, Science Park Road, Changping District, Beijing 102206 ,","place":["China"]},{"name":"Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences , 2019RU018, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]},{"name":"Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences , No. 320 Yueyang Road, Shanghai 200031 ,","place":["China"]},{"name":"Advanced Innovation Center for Human Brain Protection, Capital Medical University , No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070 ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"2024101405495371900_ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the global burden of disease study 2013","volume":"385","year":"2015","journal-title":"The Lancet"},{"key":"2024101405495371900_ref2","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1161\/CIRCRESAHA.116.308398","article-title":"Stroke risk factors, genetics, and prevention","volume":"120","author":"Boehme","year":"2017","journal-title":"Circ Res"},{"key":"2024101405495371900_ref3","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1161\/STROKEAHA.116.012802","article-title":"External validation of the ASTRAL and DRAGON scores for prediction of functional outcome in stroke","volume":"47","author":"Cooray","year":"2016","journal-title":"Stroke"},{"key":"2024101405495371900_ref4","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1161\/STROKEAHA.113.000993","article-title":"External validation of the ASTRAL score to predict 3- and 12-month functional outcome in the China National Stroke Registry","volume":"44","author":"Liu","year":"2013","journal-title":"Stroke"},{"key":"2024101405495371900_ref5","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1161\/STROKEAHA.111.000748","article-title":"The iScore predicts functional outcome in Korean patients with ischemic stroke","volume":"44","author":"Park","year":"2013","journal-title":"Stroke"},{"key":"2024101405495371900_ref6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1056\/NEJMra0905980","article-title":"Genomewide association studies and assessment of the risk of disease","volume":"363","author":"Manolio","year":"2010","journal-title":"N Engl J Med"},{"key":"2024101405495371900_ref7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.ajhg.2011.11.029","article-title":"Five years of GWAS discovery","volume":"90","author":"Visscher","year":"2012","journal-title":"Am J Hum Genet"},{"key":"2024101405495371900_ref8","doi-asserted-by":"crossref","first-page":"104383","DOI":"10.1016\/j.ebiom.2022.104383","article-title":"Prediction of type 2 diabetes using genome-wide polygenic risk score and metabolic profiles: a machine learning analysis of population-based 10-year prospective cohort study","volume":"86","author":"Hahn","year":"2022","journal-title":"EBioMedicine"},{"key":"2024101405495371900_ref9","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000007138","article-title":"Genome-wide association meta-analysis of functional outcome after ischemic stroke","volume":"92","author":"S\u00f6derholm","year":"2019","journal-title":"Neurology"},{"key":"2024101405495371900_ref10","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000012263","article-title":"Development and validation of a polygenic risk score for stroke in the Chinese population","volume":"97","author":"Lu","year":"2021","journal-title":"Neurology"},{"key":"2024101405495371900_ref11","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1136\/svn-2019-000242","article-title":"The third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: design, rationale and baseline patient characteristics","volume":"4","author":"Wang","year":"2019","journal-title":"Stroke Vasc Neurol"},{"key":"2024101405495371900_ref12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41421-023-00582-8","article-title":"The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic interplay","volume":"9","author":"Cheng","year":"2023","journal-title":"Cell Discov"},{"key":"2024101405495371900_ref13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1136\/svn-2020-000664","article-title":"Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics","volume":"6","author":"Cheng","year":"2021","journal-title":"Stroke Vasc Neurol"},{"key":"2024101405495371900_ref14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jphys.2013.12.012","article-title":"National Institutes of Health stroke scale (NIHSS)","volume":"60","author":"Kwah","year":"2014","journal-title":"J Physiother"},{"key":"2024101405495371900_ref15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/gepi.22276","article-title":"Ordered multinomial regression for genetic association analysis of ordinal phenotypes at biobank scale","volume":"44","author":"German","year":"2020","journal-title":"Genet Epidemiol"},{"key":"2024101405495371900_ref16","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/nprot.2015.105","article-title":"Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR","volume":"10","author":"Yang","year":"2015","journal-title":"Nat Protoc"},{"key":"2024101405495371900_ref17","doi-asserted-by":"publisher","first-page":"W185","DOI":"10.1093\/nar\/gkaa420","article-title":"SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update)","volume":"48","author":"Oscanoa","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2024101405495371900_ref18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"2024101405495371900_ref19","volume-title":"Proceedings of the 22nd ACM Sigkdd International Conference on Knowledge Discovery and Data Mining, San Francisco, CA, 2016","author":"Chen"},{"key":"2024101405495371900_ref20","journal-title":"31st Conference on Neural Information Processing Systems 2017"},{"key":"2024101405495371900_ref21","author":"Dorogush"},{"key":"2024101405495371900_ref22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/978-3-319-60801-3_27","article-title":"Multilayer perceptron (MLP)","author":"Taud","year":"2018","journal-title":"Geomatic Approaches for Modeling Land Change Scenarios"},{"key":"2024101405495371900_ref23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.7326\/M13-1522","article-title":"Net reclassification improvement: computation, interpretation, and controversies: a literature review and clinician\u2019s guide","volume":"160","author":"Leening","year":"2014","journal-title":"Ann Intern Med"},{"key":"2024101405495371900_ref24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/sim.4348","article-title":"Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models","volume":"31","author":"Pencina","year":"2012","journal-title":"Stat Med"},{"key":"2024101405495371900_ref25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.7326\/M18-1376","article-title":"PROBAST: a tool to assess the risk of bias and applicability of prediction model studies","volume":"170","author":"Wolff","year":"2019","journal-title":"Ann Intern Med"},{"key":"2024101405495371900_ref26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3934\/Neuroscience.2019.4.273","article-title":"\u03b2-amyloid precursor protein (APP) and the human diseases","volume":"6","author":"Vu Nguyen","year":"2019","journal-title":"AIMS Neurosci"},{"key":"2024101405495371900_ref27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1242\/jeb.203.3.447","article-title":"Identification of a ubiquitous family of membrane proteins and their expression in mouse brain","volume":"203","author":"Grossman","year":"2000","journal-title":"J Exp Biol"},{"key":"2024101405495371900_ref28","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/GIM.0b013e3181833793","article-title":"Candidate gene\/loci studies in cleft lip\/palate and dental anomalies finds novel susceptibility genes for clefts","volume":"10","author":"Vieira","year":"2008","journal-title":"Genet Med"},{"key":"2024101405495371900_ref29","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1073\/pnas.160270997","article-title":"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning","volume":"97","author":"Hu","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024101405495371900_ref30","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/ejhg.2008.106","article-title":"Gene\u2013environment interactions for complex traits: definitions, methodological requirements and challenges","volume":"16","author":"Dempfle","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"2024101405495371900_ref31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrg1578","article-title":"Gene\u2013environment interactions in human diseases","volume":"6","author":"Hunter","year":"2005","journal-title":"Nat Rev Genet"},{"key":"2024101405495371900_ref32","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/ng.608","article-title":"Common SNPs explain a large proportion of the heritability for human height","volume":"42","author":"Yang","year":"2010","journal-title":"Nat Genet"},{"key":"2024101405495371900_ref33","doi-asserted-by":"crossref","first-page":"49105","DOI":"10.1074\/jbc.M405329200","article-title":"Amyloid-\u03b2 protein precursor (A\u03b2PP) intracellular domain-associated protein-1 proteins bind to A\u03b2PP and modulate its processing in an isoform-specific manner","volume":"279","author":"Ghersi","year":"2004","journal-title":"J Biol Chem"},{"key":"2024101405495371900_ref34","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1755-8794-6-S1-S10","article-title":"Genome-wide prediction and analysis of human tissue-selective genes using microarray expression data","volume":"6","author":"Teng","year":"2013","journal-title":"BMC Med Genomics"},{"key":"2024101405495371900_ref35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3233\/JAD-2004-6108","article-title":"The intracellular localization of amyloid \u03b2 protein precursor (A\u03b2PP) intracellular domain associated protein-1 (AIDA-1) is regulated by A\u03b2PP and alternative splicing","volume":"6","author":"Ghersi","year":"2004","journal-title":"JAD"},{"key":"2024101405495371900_ref36","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2012.00037","article-title":"Developmental coordination of gene expression between synaptic partners during GABAergic circuit assembly in cerebellar cortex","volume":"6","author":"Paul","year":"2012","journal-title":"Front Neural Circuits"},{"key":"2024101405495371900_ref37","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1038\/s41467-019-11437-w","article-title":"Haploinsufficiency in the ANKS1B gene encoding AIDA-1 leads to a neurodevelopmental syndrome","volume":"10","author":"Carbonell","year":"2019","journal-title":"Nat Commun"},{"key":"2024101405495371900_ref38","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1002\/cne.22394","article-title":"Organization of amyloid-\u03b2 protein precursor intracellular domain-associated protein-1 in the rat brain","volume":"518","author":"Jacob","year":"2010","journal-title":"J Comp Neurol"},{"key":"2024101405495371900_ref39","doi-asserted-by":"publisher","first-page":"12300","DOI":"10.1523\/JNEUROSCI.0312-13.2013","article-title":"An increase in the association of GluN2B containing NMDA receptors with membrane scaffolding proteins was related to memory declines during aging","volume":"33","author":"Zamzow","year":"2013","journal-title":"J Neurosci"},{"key":"2024101405495371900_ref40","doi-asserted-by":"publisher","first-page":"8986","DOI":"10.1523\/JNEUROSCI.4029-14.2015","article-title":"ANKS1B gene product AIDA-1 controls hippocampal synaptic transmission by regulating GluN2B subunit localization","volume":"35","author":"Tindi","year":"2015","journal-title":"J Neurosci"},{"key":"2024101405495371900_ref41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuropharm.2013.08.013","article-title":"Dysfunctional synapse in Alzheimer\u2019s disease\u2014a focus on NMDA receptors","volume":"76","author":"Mota","year":"2014","journal-title":"Neuropharmacology"},{"key":"2024101405495371900_ref42","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neulet.2017.01.044","article-title":"Initial characterization of behavior and ketamine response in a mouse knockout of the post-synaptic effector gene Anks1b","volume":"641","author":"Enga","year":"2017","journal-title":"Neurosci Lett"},{"key":"2024101405495371900_ref43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archpsyc.1992.01820030038005","article-title":"Gating and habituation of the startle reflex in schizophrenic patients","volume":"49","author":"Braff","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"2024101405495371900_ref44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1469-8986.1978.tb01390.x","article-title":"Prestimulus effects on human startle reflex in normals and schizophrenics","volume":"15","author":"Braff","year":"1978","journal-title":"Psychophysiology"},{"key":"2024101405495371900_ref45","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.3390\/jcm12062206","article-title":"Assessment of low-level air pollution and cardiovascular incidence in Gdansk, Poland: time-series cross-sectional analysis","volume":"12","author":"Czernych","year":"2023","journal-title":"JCM"},{"key":"2024101405495371900_ref46","doi-asserted-by":"crossref","first-page":"e000983","DOI":"10.1161\/JAHA.114.000983","article-title":"Short-term changes in ambient particulate matter and risk of stroke: a systematic review and meta-analysis","volume":"3","author":"Wang","year":"2014","journal-title":"JAHA"},{"key":"2024101405495371900_ref47","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/jcm13030746","article-title":"Direct exposure to outdoor air pollution worsens the functional status of stroke patients treated with mechanical thrombectomy","volume":"13","author":"Lasek-Bal","year":"2024","journal-title":"JCM"},{"key":"2024101405495371900_ref48","doi-asserted-by":"publisher","first-page":"e2599","DOI":"10.1212\/WNL.0000000000011988","article-title":"Association of neighborhood socioeconomic status with outcomes in patients surviving stroke","volume":"96","author":"Stulberg","year":"2021","journal-title":"Neurology"},{"key":"2024101405495371900_ref49","doi-asserted-by":"crossref","first-page":"e2023774","DOI":"10.1001\/jamanetworkopen.2020.23774","article-title":"Assessment of neighborhood poverty, cognitive function, and prefrontal and hippocampal volumes in children","volume":"3","author":"Taylor","year":"2020","journal-title":"JAMA Netw Open"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/6\/bbae487\/59738363\/bbae487.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/25\/6\/bbae487\/59738363\/bbae487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T05:50:22Z","timestamp":1728885022000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbae487\/7820065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,9,23]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbae487","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,9,23]]},"article-number":"bbae487"}}