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However, there is a scarcity of drug repurposing methods leveraging the cellular-level information provided by single-cell RNA sequencing data. To address this need, we propose DrugReSC, an innovative approach to drug repurposing utilizing single-cell RNA sequencing data, intending to target specific cell subpopulations critical to disease pathology. DrugReSC constructs a drug-by-cell matrix representing the transcriptional relationships between individual cells and drugs and utilizes permutation-based methods to assess drug contributions to cellular phenotypic changes. We demonstrate DrugReSC\u2019s superior performance compared to existing drug repurposing methods based on bulk or single-cell RNA sequencing data across multiple cancer case studies. In summary, DrugReSC offers a novel perspective on the utilization of single-cell sequencing data in drug repurposing methods, contributing to the advancement of precision medicine for cancer.<\/jats:p>","DOI":"10.1093\/bib\/bbae490","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T03:41:34Z","timestamp":1727754094000},"source":"Crossref","is-referenced-by-count":8,"title":["DrugReSC: targeting disease-critical cell subpopulations with single-cell transcriptomic data for drug repurposing in cancer"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4959-1070","authenticated-orcid":false,"given":"Chonghui","family":"Liu","sequence":"first","affiliation":[{"name":"College of Life Science, Northeast Forestry University , 26 Hexing Road, Xiangfang District, Harbin 150040,","place":["China"]},{"name":"College of Computer and Control Engineering, Northeast Forestry University , 26 Hexing Road, Xiangfang District, Harbin 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