{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:14:50Z","timestamp":1784304890748,"version":"3.55.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation for Distinguished Young Scholars of China","award":["62225109"],"award-info":[{"award-number":["62225109"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172087"],"award-info":[{"award-number":["62172087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cell\u2013cell communication plays a critical role in maintaining normal biological functions, regulating development and differentiation, and controlling immune responses. The rapid development of single-cell RNA sequencing and spatial transcriptomics sequencing (ST-seq) technologies provides essential data support for in-depth and comprehensive analysis of cell\u2013cell communication. However, ST-seq data often contain incomplete data and systematic biases, which may reduce the accuracy and reliability of predicting cell\u2013cell communication. Furthermore, other methods for analyzing cell\u2013cell communication mainly focus on individual tissue sections, neglecting cell\u2013cell communication across multiple tissue layers, and fail to comprehensively elucidate cell\u2013cell communication networks within three-dimensional tissues. To address the aforementioned issues, we propose VGAE-CCI, a deep learning framework based on the Variational Graph Autoencoder, capable of identifying cell\u2013cell communication across multiple tissue layers. Additionally, this model can be applied to spatial transcriptomics data with missing or partially incomplete data and can clustered cells at single-cell resolution based on spatial encoding information within complex tissues, thereby enabling more accurate inference of cell\u2013cell communication. Finally, we tested our method on six datasets and compared it with other state of art methods for predicting cell\u2013cell communication. Our method outperformed other methods across multiple metrics, demonstrating its efficiency and reliability in predicting cell\u2013cell communication.<\/jats:p>","DOI":"10.1093\/bib\/bbae619","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T02:58:38Z","timestamp":1732503518000},"source":"Crossref","is-referenced-by-count":14,"title":["VGAE-CCI: variational graph autoencoder-based construction of 3D spatial cell\u2013cell communication network"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-8620","authenticated-orcid":false,"given":"Tianjiao","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Computer and Control Engineering, Northeast Forestry University , Harbin 150040 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