{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:03:48Z","timestamp":1781114628860,"version":"3.54.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":96,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20132221-E-008-079"],"award-info":[{"award-number":["112\u20132221-E-008-079"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Traditional Chinese Medicine (TCM), with its extensive knowledge base documented in ancient texts, offers a unique resource for contemporary drug discovery, particularly in combatting microbial infections. The success of antimalarial drugs like artemisinin and artesunate, derived from the TCM herb Artemisia annua L., exemplifies the potential of TCM-derived small molecules. This rich repository of natural products and intricate molecular structures could reveal novel compounds with unexplored mechanisms of action. Our study employs a multifaceted approach that combines text mining, detailed textual analysis, and modern antibacterial molecular prediction methodologies to unlock the potential of ancient TCM remedies. We use external knowledge maps, which include databases of known bioactive compounds and their targets, to identify promising TCM candidates. This approach leverages both historical texts and contemporary scientific data to explore the therapeutic potential of TCM. We discovered that herb patterns DiYu\u2192ZeXie and Kushen\u2192ShengJiang potentially combat both Grams-positive and Grams-negative bacteria. We utilized the AntiBac-Pred online tool to identify and analyze the chemical components of herbs, integrating data from ancient texts and TCMDB@Taiwan external knowledge graph. The DiYu\u2192ZeXie groups showed antimicrobial potential against resistant Staphylococcus simulans, while the Kushen\u2192ShengJiang groups exhibited dual antimicrobial effects against Bacillus subtilis. Exploring TCM\u2019s extensive repository offers numerous opportunities for discovering therapeutically active compounds. Our synergistic approach, which combines ancient wisdom with modern science, holds significant promise for enhancing our ability to combat infectious diseases. This method could pave the way for a new era of personalized medicine, addressing the urgent need for innovative treatments against multidrug-resistant bacteria and viruses.<\/jats:p>","DOI":"10.1093\/bib\/bbaf077","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T04:49:36Z","timestamp":1740545376000},"source":"Crossref","is-referenced-by-count":3,"title":["Revealing the antimicrobial potential of traditional Chinese medicine through text mining and molecular computation"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4857-5852","authenticated-orcid":false,"given":"Meng-Chi","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Engineering, National Central University (NCU) , Jhong-Li City, Taiwan ,","place":["(ROC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Engineering, National Central University (NCU) , Jhong-Li City, Taiwan ,","place":["(ROC)"]},{"name":"Education and Research Center for Technology Assisted Substance Abuse Prevention and Management, NCU , Taoyuan, Taiwan ,","place":["(ROC)"]},{"name":"Core Facilities for High Throughput Experimental Analysis, Department of Biomedical Sciences and Engineering, NCU , Taoyuan, Taiwan ,","place":["(ROC)"]},{"name":"IIHMED Reproductive Center , Taipei, Taiwan ,","place":["(ROC)"]},{"name":"Tian Medicine Phamaceutical Company Ltd. , Taipei, Taiwan ,","place":["(ROC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"IIHMED Reproductive Center , Taipei, Taiwan ,","place":["(ROC)"]},{"name":"School of Post-Baccalaureate Chinese Medicine, Tzu Chi University , Hualien, Taiwan ,","place":["(ROC)"]},{"name":"Department of Health Promotion and Health Education, National Taiwan Normal University , Taipei, Taiwan \u00a0","place":["(ROC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ching","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Engineering, National Central University (NCU) , Jhong-Li City, Taiwan ,","place":["(ROC)"]},{"name":"Education and Research Center for Technology Assisted Substance Abuse Prevention and Management, NCU , Taoyuan, Taiwan ,","place":["(ROC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"2025022604492486600_ref1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ymeth.2023.04.001","article-title":"On finding natural antibiotics based on TCM formulae","volume":"214","author":"Gao","year":"2023","journal-title":"Methods"},{"key":"2025022604492486600_ref2","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and 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