{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:53:33Z","timestamp":1776588813422,"version":"3.51.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20321"],"award-info":[{"award-number":["U23A20321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62272490"],"award-info":[{"award-number":["62272490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province of China","doi-asserted-by":"crossref","award":["2025JJ20062"],"award-info":[{"award-number":["2025JJ20062"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Drug sensitivity is essential for identifying effective treatments. Meanwhile, circular RNA (circRNA) has potential in disease research and therapy. Uncovering the associations between circRNAs and cellular drug sensitivity is crucial for understanding drug response and resistance mechanisms. In this study, we proposed DeepHeteroCDA, a novel circRNA\u2013drug sensitivity association prediction method based on multi-scale heterogeneous network and graph attention mechanism. We first constructed a heterogeneous graph based on drug\u2013drug similarity, circRNA\u2013circRNA similarity, and known circRNA\u2013drug sensitivity associations. Then, we embedded the 2D structure of drugs into the circRNA\u2013drug sensitivity heterogeneous graph and use graph convolutional networks (GCN) to extract fine-grained embeddings of drug. Finally, by simultaneously updating graph attention network for processing heterogeneous networks and GCN for processing drug structures, we constructed a multi-scale heterogeneous network and use a fully connected layer to predict the circRNA\u2013drug sensitivity associations. Extensive experimental results highlight the superior of DeepHeteroCDA. The visualization experiment shows that DeepHeteroCDA can effectively extract the association information. The case studies demonstrated the effectiveness of our model in identifying potential circRNA\u2013drug sensitivity associations. The source code and dataset are available at https:\/\/github.com\/Hhhzj-7\/DeepHeteroCDA.<\/jats:p>","DOI":"10.1093\/bib\/bbaf159","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:06:26Z","timestamp":1744621586000},"source":"Crossref","is-referenced-by-count":7,"title":["DeepHeteroCDA: circRNA\u2013drug sensitivity associations prediction via multi-scale heterogeneous network and graph attention mechanism"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1949-167X","authenticated-orcid":false,"given":"Zhijian","family":"Huang","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No. 932, South Lushan Road, Changsha 410083, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No. 932, South Lushan Road, Changsha 410083, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Software, Xinjiang University , No. 666, Shengli Road, Urumqi 830046, Xinjiang ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyu","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No. 932, South Lushan Road, Changsha 410083, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Software, Xinjiang University , No. 666, Shengli Road, Urumqi 830046, Xinjiang ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2869-1619","authenticated-orcid":false,"given":"Lei","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Central South University , No. 932, South Lushan Road, Changsha 410083, Hunan ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"key":"2025041409061487300_ref1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15476286.2015.1020271","article-title":"Regulation of circrna biogenesis","volume":"12","author":"Chen","year":"2015","journal-title":"RNA Biol"},{"key":"2025041409061487300_ref2","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.3390\/ijms15069331","article-title":"A view of pre-mrna splicing from rnase r resistant 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