{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:11:17Z","timestamp":1767276677733,"version":"3.41.2"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662022XXYJ007","2662024JC009"],"award-info":[{"award-number":["2662022XXYJ007","2662024JC009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Host-directed antivirals offer a promising strategy for addressing the challenge of viral resistance. Virus\u2013host interactions often trigger stage-specific metabolic reprogramming in the host, and the causal links between these interactions and virus-induced metabolic changes provide valuable insights for identifying host targets. In this study, we present a workflow for repurposing host-directed antivirals using virus-induced protein networks. These networks capture the dynamic progression of viral infection by integrating host proteins directly interacting with the virus and enzymes associated with significantly altered metabolic fluxes, identified through dual-species genome-scale metabolic models. This approach reveals numerous hub nodes as potential host targets. As a case study, 50 approved drugs with potential anti-influenza virus A (IVA) activity were identified through eight stage-specific IVA-induced protein networks, each comprising 699\u2013899 hub nodes. Lisinopril, saxagliptin, and gliclazide were further validated for anti-IVA efficacy in vitro through assays measuring the inhibition of cytopathic effects and viral titers in A549 cells infected with IVA PR8. This workflow paves the way for the rapid repurposing of host-directed antivirals.<\/jats:p>","DOI":"10.1093\/bib\/bbaf163","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T19:57:18Z","timestamp":1746215838000},"source":"Crossref","is-referenced-by-count":3,"title":["Metabolism-associated protein network constructing and host-directed anti-influenza drug repurposing"],"prefix":"10.1093","volume":"26","author":[{"given":"Hao","family":"Tang","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]},{"given":"Jiaojiao","family":"Yang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]},{"name":"Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]},{"name":"Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]},{"name":"International Research Center for Animal Disease, Ministry of Science and Technology of the People\u2019s Republic of China , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]},{"given":"Qingye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University , Shizishan Street 1, Wuhan, 430070 Hubei ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"2025052702074866400_ref1","doi-asserted-by":"publisher","first-page":"106708","DOI":"10.1016\/j.ijantimicag.2022.106708","article-title":"Nirmatrelvir and COVID-19: Development, pharmacokinetics, clinical efficacy, resistance, 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