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Classical experimental design presumes n\u2009&amp;gt;\u2009p for inference about parameters and its application to p\u2009&amp;gt;\u2009n can lead to over-fitting. To overcome p\u2009&amp;gt;\u2009n, MINE is an ensemble method, which makes predictions about future experiments from an existing ensemble of models consistent with available data in order to select the most informative next experiment. Its advantages are in exploration of the data for new relationships with n\u2009&amp;lt;\u2009p and being able to integrate smaller and more tractable experiments to replace adaptively one large classic experiment as discoveries are made. Thus, using MINE is model-guided and adaptive over time in a large omics study. Here, MINE is illustrated in two distinct multiyear experiments, one involving genetic networks in Neurospora crassa and a second one involving a genome-wide association study in Sorghum bicolor as a comparison to classic experimental design in an agricultural setting.<\/jats:p>","DOI":"10.1093\/bib\/bbaf167","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T13:39:03Z","timestamp":1744810743000},"source":"Crossref","is-referenced-by-count":2,"title":["MINE: a new way to design genetics experiments for discovery"],"prefix":"10.1093","volume":"26","author":[{"given":"Isaac","family":"Torres","sequence":"first","affiliation":[{"name":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 \u00a0","place":["USA"]}]},{"given":"Shufan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Bioinformatics, University of Georgia , Athens, GA 30602 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Anny","family":"Chung","sequence":"additional","affiliation":[{"name":"Plant Biology and Plant Pathology, University of Georgia , Athens, GA 30602 \u00a0","place":["USA"]}]},{"given":"H-Bernd","family":"Schuttler","sequence":"additional","affiliation":[{"name":"Physics and Astronomy, University of Georgia , Athens, GA 30602 \u00a0","place":["USA"]}]}],"member":"286","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"2025041609385943200_ref1","volume-title":"The Design of Experiments","author":"Fisher","year":"1935"},{"key":"2025041609385943200_ref2","volume-title":"The Design of Experiments","author":"Fisher","year":"1951","edition":"6th"},{"key":"2025041609385943200_ref3","volume-title":"Statistical Design and Analysis of Experiments","author":"John","year":"1971"},{"key":"2025041609385943200_ref4","doi-asserted-by":"publisher","first-page":"e1400218","DOI":"10.1126\/sciadv.1400218","article-title":"Genome-environment associations in sorghum landraces predict 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