{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:22:53Z","timestamp":1774682573774,"version":"3.50.1"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Monkeypox (Mpox) is a major global human health threat after COVID-19. Its treatment becomes complicated with type-2 diabetes (T2D). It may happen due to the influence of both disease-causing common host key genes (cHKGs). Therefore, it is necessary to explore both disease-causing cHKGs to reveal their shared pathogenetic mechanisms and candidate drugs as their common treatments without adverse side effect. This study aimed to address these issues. At first, 3 transcriptomics datasets for each of Mpox and 6 T2D datasets were analyzed and found 52 common host differentially expressed genes (cHDEGs) that can separate both T2D and Mpox patients from the control samples. Then top-ranked six cHDEGs (HSP90AA1, B2M, IGF1R, ALD1HA1, ASS1, and HADHA) were detected as the T2D-causing cHKGs that are associated with the complexity of Mpox through the protein\u2013protein interaction network analysis. Then common pathogenetic processes between T2D and Mpox were disclosed by cHKG-set enrichment analysis with biological processes, molecular functions, cellular components and Kyoto Encyclopedia of Genes and Genomes pathways, and regulatory network analysis with transcription factors and microRNAs. Finally, cHKG-guided top-ranked three drug molecules (tecovirimat, vindoline, and brincidofovir) were recommended as the repurposable common therapeutic agents for both Mpox and T2D by molecular docking. The absorption, distribution, metabolism, excretion, and toxicity and drug-likeness analysis of these drug molecules indicated their good pharmacokinetics properties. The 100-ns molecular dynamics simulation results (root mean square deviation, root mean square fluctuation, and molecular mechanics generalized born surface area) with the top-ranked three complexes ASS1-tecovirimat, ALDH1A1-vindoline, and B2M-brincidofovir exhibited good pharmacodynamics properties. Therefore, the results provided in this article might be important resources for diagnosis and therapies of Mpox patients who are also suffering from T2D.<\/jats:p>","DOI":"10.1093\/bib\/bbaf215","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:27:44Z","timestamp":1747290464000},"source":"Crossref","is-referenced-by-count":5,"title":["<i>In-silico<\/i> discovery of type-2 diabetes-causing host key genes that are associated with the complexity of monkeypox and repurposing common drugs"],"prefix":"10.1093","volume":"26","author":[{"given":"Alvira","family":"Ajadee","sequence":"first","affiliation":[{"name":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]}]},{"given":"Sabkat","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]}]},{"given":"Md Ahad","family":"Ali","sequence":"additional","affiliation":[{"name":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]},{"name":"Department of Chemistry, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]}]},{"given":"Md Manir Hossain","family":"Mollah","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Independent University Bangladesh , Bashundhara Residential Area, Dhaka 1245 ,","place":["Bangladesh"]}]},{"given":"Reaz","family":"Ahmmed","sequence":"additional","affiliation":[{"name":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]},{"name":"Department of Biochemistry and Molecular Biology, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]}]},{"given":"Md Nurul Haque","family":"Mollah","sequence":"additional","affiliation":[{"name":"Bioinformatics Lab (Dry), Department of Statistics, University of Rajshahi , Rajshahi 6205 ,","place":["Bangladesh"]}]}],"member":"286","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"2025052711504490600_ref1","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1016\/S0140-6736(22)01437-4","article-title":"Monkeypox as a PHEIC: implications for Global Health Governance","volume":"400","author":"Wenham","year":"2022","journal-title":"Lancet"},{"key":"2025052711504490600_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/GH9.0000000000000110","article-title":"Amid COVID-19 and monkeypox: tomato flu outbreak in India","volume":"6","author":"D\u2019Souza","year":"2023","journal-title":"IJS: Glob Health"},{"key":"2025052711504490600_ref3","doi-asserted-by":"publisher","first-page":"905","DOI":"10.3390\/v15040905","article-title":"Monkeypox virus in animals: current knowledge of viral transmission and pathogenesis in wild animal reservoirs and captive animal models","volume":"15","author":"Falendysz","year":"2023","journal-title":"Viruses"},{"key":"2025052711504490600_ref4","volume-title":"2022\u20132023 Mpox Outbreak Global Map"},{"key":"2025052711504490600_ref5","volume-title":"2022\u20132023 Mpox Outbreak Global Map Data as of 06 Aug 2024 5:30 PM EDT"},{"key":"2025052711504490600_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00574-6","article-title":"Prevention of Monkeypox with Vaccines: A Rapid Review","volume-title":"Lancet Infect Dis","author":""},{"key":"2025052711504490600_ref7","first-page":"1","volume-title":"Vaccines and Immunization for Monkeypox","author":"SE Programme","year":"2022"},{"key":"2025052711504490600_ref8","doi-asserted-by":"publisher","first-page":"559595","DOI":"10.3389\/fpubh.2021.559595","article-title":"Susceptibility for some infectious diseases in patients with diabetes: the key role of glycemia","volume":"9","author":"Ch\u00e1vez-Reyes","year":"2021","journal-title":"Front Public Health"},{"key":"2025052711504490600_ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2022.919223","article-title":"Respiratory tract infections in diabetes\u2014lessons from tuberculosis and influenza to guide understanding of COVID-19 severity","volume":"13","author":"Al-Sayyar","year":"2022","journal-title":"Front Endocrinol"},{"key":"2025052711504490600_ref10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2022.1042362","article-title":"The role of pathogens in diabetes pathogenesis and the potential of immunoproteomics as a diagnostic and prognostic tool","volume":"13","author":"Sohail","year":"2022","journal-title":"Front Microbiol"},{"key":"2025052711504490600_ref11","doi-asserted-by":"publisher","first-page":"e15021","DOI":"10.1016\/j.heliyon.2023.e15021","article-title":"Diabetogenic viruses: linking viruses to diabetes mellitus","volume":"9","author":"Rajsfus","year":"2023","journal-title":"Heliyon"},{"key":"2025052711504490600_ref12","doi-asserted-by":"publisher","first-page":"108637","DOI":"10.1016\/j.diabres.2020.108637","article-title":"Type 2 diabetes and viral infection; cause and effect of disease","volume":"172","author":"Turk Wensveen","year":"2021","journal-title":"Diabetes Res Clin Pract"},{"key":"2025052711504490600_ref13","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.94253","article-title":"Infections in patients with diabetes mellitus: a review of pathogenesis","volume-title":"Indian Journal of Endocrinology and Metabolism","author":"Casqueiro"},{"key":"2025052711504490600_ref14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","author":"Ong","year":"2023","journal-title":"Lancet"},{"key":"2025052711504490600_ref15","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/s41577-022-00775-4","article-title":"Monkeypox: disease epidemiology, host immunity and clinical interventions","volume":"22","author":"Lum","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"2025052711504490600_ref16","doi-asserted-by":"publisher","first-page":"104424","DOI":"10.1016\/j.ebiom.2022.104424","article-title":"The land-scape of immune response to monkeypox virus","volume":"87","author":"Li","year":"2023","journal-title":"EBioMedicine"},{"key":"2025052711504490600_ref17","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.2337\/dc14-3008","article-title":"Profile of the immune and inflammatory response in individuals with prediabetes and type 2 diabetes","volume":"38","author":"Grossmann","year":"2015","journal-title":"Diabetes Care"},{"key":"2025052711504490600_ref18","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2025052711504490600_ref19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12933-023-01965-7","article-title":"The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction","volume":"22","author":"An","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"2025052711504490600_ref20","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3390\/oxygen2030018","article-title":"Roles of reactive oxygen species in vascular complications of diabetes: therapeutic properties of medicinal plants and food","volume":"2","author":"Tan","year":"2022","journal-title":"Oxygen"},{"key":"2025052711504490600_ref21","doi-asserted-by":"publisher","first-page":"5376","DOI":"10.3390\/ijms20215376","article-title":"The pathogenesis of sepsis and potential therapeutic targets","volume":"20","author":"Huang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025052711504490600_ref22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.pcd.2023.01.008","article-title":"Diabetes mellitus: lessons from COVID-19 for monkeypox infection","volume":"17","author":"Ruiz-Pacheco","year":"2023","journal-title":"Prim Care Diabetes"},{"key":"2025052711504490600_ref23","doi-asserted-by":"publisher","DOI":"10.20473\/bikk.V33.3.2021.213-223","article-title":"Chickenpox mimicking monkeypox in adult with diabetes mellitus and acute kidney injury: diagnosis and management","volume-title":"Berk Ilmu Kesehat Kulit dan Kelamin","author":"Wardiana"},{"key":"2025052711504490600_ref24","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The effects of type 2 diabetes mellitus on organ metabolism and the immune system","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front Immunol"},{"key":"2025052711504490600_ref25","doi-asserted-by":"publisher","first-page":"1249501","DOI":"10.3389\/fgene.2024.1249501","article-title":"Identification of common genes and pathways between type 2 diabetes and COVID-19","volume":"15","author":"Wang","year":"2024","journal-title":"Front Genet"},{"key":"2025052711504490600_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101044","article-title":"Diabetes, Infection Risk and COVID-19","volume-title":"Mol Metab","author":""},{"key":"2025052711504490600_ref27","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02841-19","article-title":"Glycemic variability in diabetes increases the severity of influenza","volume":"11","author":"Marshall","year":"2020","journal-title":"MBio"},{"key":"2025052711504490600_ref28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12985-021-01486-3","article-title":"Association of the host genetic factors, hypercholesterolemia and diabetes with mild influenza in an Iranian population","volume":"18","author":"Mehrbod","year":"2021","journal-title":"Virol J"},{"key":"2025052711504490600_ref29","doi-asserted-by":"publisher","first-page":"553","DOI":"10.2147\/DMSO.S178894","article-title":"Identification of key gene pathways and coexpression networks of islets in human type 2 diabetes","volume":"11","author":"Li","year":"2018","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2025052711504490600_ref30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.virol.2015.10.005","article-title":"ICAM-1 regulates the survival of influenza virus in lung epithelial cells during the early stages of infection","volume":"487","author":"Othumpangat","year":"2016","journal-title":"Virology"},{"key":"2025052711504490600_ref31","doi-asserted-by":"publisher","first-page":"e30483","DOI":"10.1016\/j.heliyon.2024.e30483","article-title":"A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions","volume":"10","author":"Tang","year":"2024","journal-title":"Heliyon"},{"key":"2025052711504490600_ref32","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.jiph.2023.01.015","article-title":"Evaluation of differentially expressed genes during replication using gene expression landscape of monkeypox-infected MK2 cells: a bioinformatics and systems biology approach to understanding the genomic pattern of viral replication","volume":"16","author":"Chakraborty","year":"2023","journal-title":"J Infect Public Health"},{"key":"2025052711504490600_ref33","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1007\/s00125-017-4336-x","article-title":"Metformin: clinical use in type 2 diabetes","volume":"60","author":"Sanchez-Rangel","year":"2017","journal-title":"Diabetologia"},{"key":"2025052711504490600_ref34","doi-asserted-by":"publisher","first-page":"CD006060","DOI":"10.1002\/14651858.CD006060.pub2","article-title":"Pioglitazone for type 2 diabetes mellitus","volume":"2006","author":"Richter","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"2025052711504490600_ref35","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.3201\/eid2912.231146","article-title":"Tecovirimat resistance in Mpox patients, United States, 2022\u20132023","volume":"29","author":"Smith","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"2025052711504490600_ref36","doi-asserted-by":"publisher","first-page":"105995","DOI":"10.1016\/j.antiviral.2024.105995","article-title":"Treatment efficacy of cidofovir and brincidofovir against clade II monkeypox virus isolates","volume":"231","author":"Pr\u00e9vost","year":"2024","journal-title":"Antivir Res"},{"key":"2025052711504490600_ref37","doi-asserted-by":"publisher","DOI":"10.1183\/1393003.congress-2017.pa698","article-title":"Disease-specific medication, patient-reported diagnoses and their relation to COPD severity for common comorbidities in COPD","volume-title":"Proceedings of the European Respiratory Journal","author":"Lucke"},{"key":"2025052711504490600_ref38","doi-asserted-by":"publisher","first-page":"12339","DOI":"10.1038\/srep12339","article-title":"Label propagation prediction of drug-drug interactions based on clinical side effects","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"2025052711504490600_ref39","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s40266-020-00747-0","article-title":"Adverse drug events in patients with chronic kidney disease associated with multiple drug interactions and polypharmacy","volume":"37","author":"Sommer","year":"2020","journal-title":"Drugs Aging"},{"key":"2025052711504490600_ref40","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1111\/jgs.14870","article-title":"Common drug side effects and drug-drug interactions in elderly adults in primary care","volume":"65","author":"Merel","year":"2017","journal-title":"J Am Geriatr Soc"},{"key":"2025052711504490600_ref41","first-page":"420","article-title":"Potential side-effects and interactions in multiple medication in elderly patients: methodology and results of the berlin study of aging","volume":"28","author":"Borchelt","year":"1995","journal-title":"Z Gerontol Geriatr"},{"key":"2025052711504490600_ref42","doi-asserted-by":"publisher","first-page":"19133","DOI":"10.1038\/s41598-024-69302-w","article-title":"Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications","volume":"14","author":"Ahmmed","year":"2024","journal-title":"Sci Rep"},{"key":"2025052711504490600_ref43","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1038\/s41598-023-31276-6","article-title":"Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing","volume":"13","author":"Islam","year":"2023","journal-title":"Sci Rep"},{"key":"2025052711504490600_ref44","doi-asserted-by":"publisher","first-page":"e0304425","DOI":"10.1371\/journal.pone.0304425","article-title":"In-silico discovery of common molecular signatures for which SARS-CoV-2 infections and lung diseases stimulate each other, and drug repurposing","volume":"19","author":"Alamin","year":"2024","journal-title":"PLoS One"},{"key":"2025052711504490600_ref45","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s10142-023-01185-y","article-title":"Hyper-methylation of ABCG1 as an epigenetics biomarker in non-small cell lung cancer","volume":"23","author":"Tran","year":"2023","journal-title":"Funct Integr Genomics"},{"key":"2025052711504490600_ref46","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.3390\/biomedicines9091144","article-title":"Identifying GPSM family members as potential biomarkers in breast cancer: a comprehensive bioinformatics analysis","volume":"9","author":"Dang","year":"2021","journal-title":"Biomedicine"},{"key":"2025052711504490600_ref47","doi-asserted-by":"publisher","first-page":"7363","DOI":"10.1038\/s41598-025-91875-3","article-title":"Screening of common genomic biomarkers to explore common drugs for the treatment of pancreatic and kidney cancers with type-2 diabetes through bioinformatics analysis","volume":"15","author":"Ajadee","year":"2025","journal-title":"Sci Rep"},{"key":"2025052711504490600_ref48","doi-asserted-by":"publisher","first-page":"e0319028","DOI":"10.1371\/journal.pone.0319028","article-title":"Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analysis","volume":"20","author":"Mahmud","year":"2025","journal-title":"PLoS One"},{"key":"2025052711504490600_ref49","doi-asserted-by":"publisher","first-page":"e0310843","DOI":"10.1371\/journal.pone.0310843","article-title":"Screening of differential gene expression patterns through survival analysis for diagnosis, prognosis and therapies of clear cell renal cell carcinoma","volume":"19","author":"Ajadee","year":"2024","journal-title":"PLoS One"},{"key":"2025052711504490600_ref50","doi-asserted-by":"publisher","first-page":"108245","DOI":"10.1016\/j.compbiolchem.2024.108245","article-title":"Gene-expression profile analysis to disclose diagnostics and therapeutics biomarkers for thyroid carcinoma","volume":"113","author":"Mahmud","year":"2024","journal-title":"Comput Biol Chem"},{"key":"2025052711504490600_ref51","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.3390\/ijms18081652","article-title":"Transcriptome profiling in human diseases: new advances and perspectives","volume":"18","author":"Casamassimi","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2025052711504490600_ref52","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a006198","article-title":"Toward transcriptomics as a primary tool for rare disease investigation","volume":"8","author":"Montgomery","year":"2022","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"2025052711504490600_ref53","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3390\/genes16020135","article-title":"Genomic and transcriptomic approaches advance the diagnosis and prognosis of neurodegenerative diseases","volume":"16","author":"Liu","year":"2025","journal-title":"Genes (Basel)"},{"key":"2025052711504490600_ref54","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1743-422X-10-61","article-title":"Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes","volume":"10","author":"Bourquain","year":"2013","journal-title":"Virol J"},{"key":"2025052711504490600_ref55","doi-asserted-by":"publisher","first-page":"e15615","DOI":"10.1371\/journal.pone.0015615","article-title":"Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus","volume":"6","author":"Rubins","year":"2011","journal-title":"PLoS One"},{"key":"2025052711504490600_ref56","doi-asserted-by":"publisher","first-page":"e2628","DOI":"10.1371\/journal.pone.0002628","article-title":"Comparative analysis of viral gene expression programs during poxvirus infection: a transcriptional map of the vaccinia and monkeypox genomes","volume":"3","author":"Rubins","year":"2008","journal-title":"PLoS One"},{"key":"2025052711504490600_ref57","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1210\/jc.2011-3454","article-title":"Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes","volume":"97","author":"Tienen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2025052711504490600_ref58","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1074\/jbc.M110.200295","article-title":"Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells","volume":"286","author":"Dominguez","year":"2011","journal-title":"J Biol Chem"},{"key":"2025052711504490600_ref59","doi-asserted-by":"publisher","first-page":"e53522","DOI":"10.1371\/journal.pone.0053522","article-title":"Systems biology approach reveals genome to phenome correlation in type 2 diabetes","volume":"8","author":"Jain","year":"2013","journal-title":"PLoS One"},{"key":"2025052711504490600_ref60","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00438-024-02139-0","article-title":"Potential molecular patterns for tuberculosis susceptibility in diabetic patients with poor glycaemic control: a pilot study","volume":"299","author":"Jaime-S\u00e1nchez","year":"2024","journal-title":"Mol Gen Genomics"},{"key":"2025052711504490600_ref61","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s00125-017-4500-3","article-title":"Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes","volume":"61","author":"Solimena","year":"2018","journal-title":"Diabetologia"},{"key":"2025052711504490600_ref62","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3389\/fgene.2018.00679","article-title":"Systems genomics of thigh adipose tissue from Asian Indian type-2 diabetics revealed distinct protein interaction hubs","volume":"9","author":"Tiwari","year":"2018","journal-title":"Front Genet"},{"key":"2025052711504490600_ref63","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012373944-5.00178-4","article-title":"Antiviral Agents","volume-title":"Encyclopedia of Microbiology","author":""},{"key":"2025052711504490600_ref64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1040","article-title":"DGIdb 5.0: Rebuilding the Drug\u2013Gene Interaction Database for Precision Medicine and Drug Discovery Platforms","volume-title":"Nucleic Acids Res","author":""},{"key":"2025052711504490600_ref65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"2025052711504490600_ref66","volume-title":"Introduction to Preprocessing: RMA (Robust Multi-Array Average)","author":"Monograph","year":"2014"},{"key":"2025052711504490600_ref67","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The SVA package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"2025052711504490600_ref68","first-page":"1","article-title":"Performing differential gene expression analysis","volume-title":"Read counts to DGE, Part III","author":"D\u00fcndar","year":"2020"},{"key":"2025052711504490600_ref69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-26277-w","article-title":"Identification of key immune-related genes in dilated cardiomyopathy using bioinformatics analysis","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"2025052711504490600_ref70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/or.2023.8555","article-title":"Gene expression profiling of peripheral blood mononuclear cells from women with cervical lesions reveals new markers of cancer","volume":"49","author":"Ndiaye","year":"2023","journal-title":"Oncol Rep"},{"key":"2025052711504490600_ref71","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING V11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-19942-z","article-title":"Towards a unified open access dataset of molecular interactions","volume":"11","author":"Porras","year":"2020","journal-title":"Nat Commun"},{"key":"2025052711504490600_ref73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"CytoHubba: identifying hub objects and sub-networks from complex Interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"key":"2025052711504490600_ref74","doi-asserted-by":"publisher","first-page":"D260","DOI":"10.1093\/nar\/gkx1126","article-title":"JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework","volume-title":"Nucleic Acids Research","author":"Khan","year":"2018"},{"key":"2025052711504490600_ref75","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1261\/rna.2239606","article-title":"TarBase: a comprehensive database of experimentally supported animal microRNA targets","volume":"12","author":"Sethupathy","year":"2006","journal-title":"RNA"},{"key":"2025052711504490600_ref76","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref77","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"2025052711504490600_ref78","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"2025052711504490600_ref79","doi-asserted-by":"publisher","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref80","first-page":"2021.04.15.439962","article-title":"GeneCodis 4: expanding the modular enrichment analysis to regulatory elements","volume":"10","author":"Garc\u00eda-Moreno","year":"2021","journal-title":"bioRxiv"},{"key":"2025052711504490600_ref81","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1038\/s41577-020-00473-z","article-title":"NOD-like receptor-mediated plant immunity: from structure to cell death","volume":"21","author":"Saur","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"2025052711504490600_ref82","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref83","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: an automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref84","doi-asserted-by":"publisher","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","article-title":"PubChem 2019 update: improved access to chemical data","volume":"47","author":"Kim","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref85","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"Software news and updates AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J Comput Chem"},{"key":"2025052711504490600_ref86","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"","journal-title":"J Cheminform"},{"key":"2025052711504490600_ref87","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s43088-020-00059-7","article-title":"In silico molecular docking studies and MM\/GBSA analysis of coumarin-carbonodithioate hybrid derivatives divulge the anticancer potential against breast cancer","volume":"9","author":"Pattar","year":"2020","journal-title":"Beni-Suef Univ J Basic Appl Sci"},{"key":"2025052711504490600_ref88","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1080\/07391102.2018.1426043","article-title":"Docking, molecular dynamics, binding energy-MM-PBSA studies of naphthofuran derivatives to identify potential dual inhibitors against BACE-1 and GSK-3\u03b2","volume":"37","author":"Kumar","year":"2019","journal-title":"J Biomol Struct Dyn"},{"key":"2025052711504490600_ref89","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.256261","article-title":"Molecular docking studies and evaluation of the antiretroviral activity and cytotoxicity of the species Lafoensia pacari Saint-Hilaire","volume":"82","author":"Fonseca","year":"2022","journal-title":"Brazilian J Biol"},{"key":"2025052711504490600_ref90","doi-asserted-by":"publisher","first-page":"3338549","DOI":"10.1155\/2022\/3338549","article-title":"Screening of potential breast cancer inhibitors through molecular docking and molecular dynamics simulation","volume":"2022","author":"Pandi","year":"2022","journal-title":"Biomed Res Int"},{"key":"2025052711504490600_ref91","doi-asserted-by":"publisher","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref92","doi-asserted-by":"publisher","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref93","doi-asserted-by":"publisher","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"PkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J Med Chem"},{"key":"2025052711504490600_ref94","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead- and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov Today Technol"},{"key":"2025052711504490600_ref95","doi-asserted-by":"publisher","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem substance and compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2025052711504490600_ref96","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/jcc.23354","article-title":"CHARMM36 all-atom additive protein force field: validation based on comparison to NMR data","volume":"34","author":"Huang","year":"2013","journal-title":"J Comput Chem"},{"key":"2025052711504490600_ref97","first-page":"252","article-title":"Gromacs: a parallel computer for molecular dynamics simulations design of polarizable analytical potentials view project density matrix evolution view project","volume":"92","author":"Bekker","year":"1993","journal-title":"Phys Comput"},{"key":"2025052711504490600_ref98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2024.1360745","article-title":"In silico evaluation of anti-colorectal cancer inhibitors by resveratrol derivatives targeting armadillo repeats domain of APC: molecular docking and molecular dynamics simulation","volume":"14","author":"Akash","year":"2024","journal-title":"Front Oncol"},{"key":"2025052711504490600_ref99","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1021\/ci980029a","article-title":"Prediction of human intestinal absorption of drug compounds from molecular structure","volume":"38","author":"Wessel","year":"1998","journal-title":"J Chem Inf Comput Sci"},{"key":"2025052711504490600_ref100","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1021\/jm000292e","article-title":"Prediction of drug absorption using multivariate statistics","volume":"43","author":"Egan","year":"2000","journal-title":"J Med Chem"},{"key":"2025052711504490600_ref101","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/00004647-199707000-00001","article-title":"Drug delivery to the brain","volume":"17","author":"Pardridge","year":"1997","journal-title":"J Cereb Blood Flow Metab"},{"key":"2025052711504490600_ref102","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312808","article-title":"Cytochrome P450 enzymes and drug metabolism in humans","volume":"22","author":"Zhao","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025052711504490600_ref103","doi-asserted-by":"publisher","DOI":"10.34133\/bdr.0002","article-title":"De Novo Biosynthesis of Vindoline and Catharanthine in Saccharomyces Cerevisiae","volume":"2022","author":"","journal-title":"BioDesign Res"},{"key":"2025052711504490600_ref104","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.3892\/ol.2018.8990","article-title":"Overexpression of macrophage migration inhibitory factor and functionally-related genes, D-DT, CD74, CD44, CXCR2 and CXCR4, in glioblastoma","volume":"16","author":"Presti","year":"2018","journal-title":"Oncol Lett"},{"key":"2025052711504490600_ref105","doi-asserted-by":"publisher","first-page":"747","DOI":"10.3390\/brainsci10100747","article-title":"Comprehensive analysis of RNA-seq gene expression profiling of brain transcriptomes reveals novel genes, regulators, and pathways in autism spectrum disorder","volume":"10","author":"Rahman","year":"2020","journal-title":"Brain Sci"},{"key":"2025052711504490600_ref106","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.drudis.2018.11.003","article-title":"Role of MIF and D-DT in immune-inflammatory, autoimmune, and chronic respiratory diseases: from pathogenic factors to therapeutic targets","volume":"24","author":"G\u00fcnther","year":"2019","journal-title":"Drug Discov Today"},{"key":"2025052711504490600_ref107","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.drudis.2015.10.015","article-title":"Emerging therapeutic targets for the treatment of hepatic fibrosis","volume":"21","author":"Fagone","year":"2016","journal-title":"Drug Discov Today"},{"key":"2025052711504490600_ref108","doi-asserted-by":"publisher","first-page":"402","DOI":"10.7150\/ijms.67815","article-title":"Potential genes associated with COVID-19 and comorbidity","volume":"19","author":"Feng","year":"2022","journal-title":"Int J Med Sci"},{"key":"2025052711504490600_ref109","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nsmb.1591","article-title":"Converging concepts of protein folding in vitro and in vivo","volume":"16","author":"Hartl","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"2025052711504490600_ref110","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.jcjd.2016.05.016","article-title":"Heat shock proteins and diabetes","volume":"40","author":"Zilaee","year":"2016","journal-title":"Can J Diabetes"},{"key":"2025052711504490600_ref111","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s41392-020-00233-4","article-title":"Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development","volume":"5","author":"Wan","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"2025052711504490600_ref112","doi-asserted-by":"publisher","first-page":"944722","DOI":"10.3389\/fonc.2022.944722","article-title":"The immune-related role of beta-2-microglobulin in melanoma","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"2025052711504490600_ref113","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2012.36.3.167","article-title":"Retinoid metabolism and diabetes mellitus","volume-title":"Diabetes Metab J","author":"Rhee"},{"key":"2025052711504490600_ref114","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bcp.2008.10.011","article-title":"Retinoic acid modulates retinaldehyde dehydrogenase 1 gene expression through the induction of GADD153-C\/EBPbeta interaction","volume":"77","author":"Elizondo","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"2025052711504490600_ref115","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.3390\/ijms23052682","article-title":"Aldehyde dehydrogenase 2 as a therapeutic target in oxidative stress-related diseases: post-translational modifications deserve more attention","volume":"23","author":"Gao","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025052711504490600_ref116","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.freeradbiomed.2012.11.010","article-title":"Aldehyde dehydrogenases in cellular responses to oxidative\/electrophilic stress","volume":"56","author":"Singh","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"2025052711504490600_ref117","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.2337\/db06-0414","article-title":"The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study","volume":"55","author":"Hove","year":"2006","journal-title":"Diabetes"},{"key":"2025052711504490600_ref118","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41392-023-01675-2","article-title":"Mpox (formerly monkeypox): pathogenesis, prevention, and treatment","volume":"8","author":"Lu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2025052711504490600_ref119","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Salvador","year":"2025","journal-title":"N Engl J Med"},{"key":"2025052711504490600_ref120","doi-asserted-by":"publisher","first-page":"193095","DOI":"10.1155\/2014\/193095","article-title":"Nitric oxide, oxidative stress, and P66Shc interplay in diabetic endothelial dysfunction","volume":"2014","author":"Magenta","year":"2014","journal-title":"Biomed Res Int"},{"key":"2025052711504490600_ref121","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1146\/annurev-virology-091919-102416","article-title":"Viruses and metabolism: the effects of viral infections and viral insulins on host metabolism","volume":"8","author":"Girdhar","year":"2021","journal-title":"Annu Rev Virol"},{"key":"2025052711504490600_ref122","doi-asserted-by":"publisher","first-page":"100208","DOI":"10.1016\/j.xgen.2022.100208","article-title":"Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes","volume":"2","author":"Gardner","year":"2022","journal-title":"Cell Genom"},{"key":"2025052711504490600_ref123","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41586-020-2369-7","article-title":"IGF1R is an entry receptor for respiratory syncytial virus","volume":"583","author":"Griffiths","year":"2020","journal-title":"Nature"},{"key":"2025052711504490600_ref124","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u039aB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"2025052711504490600_ref125","doi-asserted-by":"publisher","first-page":"856963","DOI":"10.3389\/fonc.2022.856963","article-title":"YY1 is a key player in melanoma immunotherapy\/targeted treatment resistance","volume":"12","author":"Kwiatkowska","year":"2022","journal-title":"Front Oncol"},{"key":"2025052711504490600_ref126","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.3390\/cells11162581","article-title":"The stress-responsive microRNA-34a alters insulin signaling and actions in adipocytes through induction of the tyrosine phosphatase PTP1B","volume":"11","author":"Cornejo","year":"2022","journal-title":"Cells"},{"key":"2025052711504490600_ref127","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.3892\/mmr.2015.4416","article-title":"Peripheral blood microRNA-15a is a potential biomarker for type 2 diabetes mellitus and pre-diabetes","volume-title":"Mol Med Rep","author":"Kafaji","year":"2015"},{"key":"2025052711504490600_ref128","first-page":"5683","article-title":"MiR-15a\/16 are upregulated in the serum of neonatal sepsis patients and inhibit the LPS-induced inflammatory pathway","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"2025052711504490600_ref129","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3389\/fphar.2020.01253","article-title":"The C-C chemokine receptor type 4 is an immunomodulatory target of hydroxychloroquine","volume":"11","author":"Beck","year":"2020","journal-title":"Front Pharmacol"},{"key":"2025052711504490600_ref130","doi-asserted-by":"publisher","first-page":"717141","DOI":"10.3389\/fbinf.2021.717141","article-title":"Screening of potent phytochemical inhibitors against SARS-CoV-2 main protease: an integrative computational approach","volume":"1","author":"Mahmud","year":"2021","journal-title":"Front Bioinform"},{"key":"2025052711504490600_ref131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms14092","article-title":"Centrality in the host-pathogen interactome is associated with pathogen fitness during infection","volume":"8","author":"Crua Asensio","year":"2017","journal-title":"Nat Commun"},{"key":"2025052711504490600_ref132","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.tim.2023.09.009","article-title":"Human\u2013gut bacterial protein\u2013protein interactions: understudied but impactful to human health","volume":"32","author":"Balint","year":"2023","journal-title":"Trends Microbiol"},{"key":"2025052711504490600_ref133","doi-asserted-by":"publisher","first-page":"432","DOI":"10.3390\/ph17040432","article-title":"Discovery of bacterial key genes from 16S rRNA-seq profiles that are associated with the complications of SARS-CoV-2 infections and provide therapeutic indications","volume":"17","author":"Kibria","year":"2024","journal-title":"Pharmaceuticals"},{"key":"2025052711504490600_ref134","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.3390\/vaccines10081248","article-title":"Meta-data analysis to explore the hub of the hub-genes that influence SARS-CoV-2 infections highlighting their pathogenetic processes and drugs repurposing","volume":"10","author":"Mosharaf","year":"2022","journal-title":"Vaccine"},{"key":"2025052711504490600_ref135","doi-asserted-by":"publisher","first-page":"630","DOI":"10.3390\/microorganisms12030630","article-title":"Exploring viral\u2013host protein interactions as antiviral therapies: a computational perspective","volume":"12","author":"Idrees","year":"2024","journal-title":"Microorganisms"},{"key":"2025052711504490600_ref136","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.3389\/fmicb.2017.01557","article-title":"Protein-protein interactions in virus-host systems","volume":"8","author":"Brito","year":"2017","journal-title":"Front Microbiol"},{"key":"2025052711504490600_ref137","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2022.959586","article-title":"Virus-host protein-protein interactions as molecular drug targets for arboviral infections","volume":"2","author":"Bhutkar","year":"2022","journal-title":"Front Virol"},{"key":"2025052711504490600_ref138","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1080\/07391102.1997.10508975","article-title":"Journal of biomolecular structure and dynamics","volume":"15","author":"Sarma","year":"1997","journal-title":"J Biomol Struct Dyn"},{"key":"2025052711504490600_ref139","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1186\/s12864-018-4924-2","article-title":"A generalized approach to predicting protein-protein interactions between virus and host","volume":"19","author":"Zhou","year":"2018","journal-title":"BMC Genomics"},{"key":"2025052711504490600_ref140","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/B978-0-12-811257-1.00003-6","article-title":"Replication and expression strategies of viruses","author":"Rampersad","year":"2018","journal-title":"Viruses"},{"key":"2025052711504490600_ref141","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/14787210.2020.1819791","article-title":"An overview of tecovirimat for smallpox treatment and expanded anti-orthopoxvirus applications","volume":"19","author":"Russo","year":"2021","journal-title":"Expert Rev Anti-Infect Ther"},{"key":"2025052711504490600_ref142","doi-asserted-by":"publisher","first-page":"5570","DOI":"10.1128\/AAC.02814-14","article-title":"In vitro efficacy of brincidofovir against variola virus","volume":"58","author":"Olson","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2025052711504490600_ref143","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jep.2013.08.043","article-title":"Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models","volume":"150","author":"Yao","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"2025052711504490600_ref144","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/biomedicines7030059","article-title":"Vindoline\u2014a natural product from Catharanthus roseus reduces hyperlipidemia and renal pathophysiology in experimental type 2 diabetes","volume":"7","author":"Oguntibeju","year":"2019","journal-title":"Biomedicine"},{"key":"2025052711504490600_ref145","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1517\/17460441.3.6.655","article-title":"Update on in vitro cytotoxicity assays for drug development","volume":"3","author":"Niles","year":"2008","journal-title":"Expert Opin Drug Discov"},{"key":"2025052711504490600_ref146","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1208\/s12249-017-0763-8","article-title":"Ocular cubosome drug delivery system for timolol maleate: preparation, characterization, cytotoxicity, ex vivo, and in vivo evaluation","volume":"18","author":"Huang","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"2025052711504490600_ref147","doi-asserted-by":"publisher","first-page":"619","DOI":"10.2144\/000112776","article-title":"Twenty-five years of quantitative PCR for gene expression analysis","volume":"44","author":"VanGuilder","year":"2008","journal-title":"BioTechniques"},{"key":"2025052711504490600_ref148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-021-04175-8","article-title":"A novel essential protein identification method based on PPI networks and gene expression data","volume":"22","author":"Zhong","year":"2021","journal-title":"BMC Bioinformatics"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/3\/bbaf215\/63183299\/bbaf215.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/3\/bbaf215\/63183299\/bbaf215.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:50:54Z","timestamp":1748361054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbaf215\/8131743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":148,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbaf215","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,5,1]]},"article-number":"bbaf215"}}