{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T04:40:14Z","timestamp":1774413614915,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23JS1400700"],"award-info":[{"award-number":["23JS1400700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Neil Shen\u2019s SJTU Medical Research Fund"},{"name":"Science and Technology Innovation Key R&D Program of Chongqing","award":["CSTB2024TIAD-STX0006"],"award-info":[{"award-number":["CSTB2024TIAD-STX0006"]}]},{"name":"Computational Biology Program of Science and Technology Commission of Shanghai Municipality","award":["24JS2840300"],"award-info":[{"award-number":["24JS2840300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Effective classification methods and prognostic models enable more accurate classification and treatment of hepatocellular carcinoma (HCC) patients. However, the weak correlation between RNA and protein data has limited the clinical utility of previous RNA-based prognostic models for HCC. In this work, we constructed a novel prognostic framework for HCC patients using seven differentially expressed proteins associated with ferroptosis and iron metabolism. Furthermore, this prognostic model robustly classifies HCC patients into three clinically relevant risk groups. Significant differences in overall survival, age, tumor differentiation, microvascular invasion, distant metastasis, and alpha-fetoprotein levels were observed among the risk groups. Based on the prognostic model and known biological pathways, we explored the potential mechanisms underlying the inconsistent differential expression patterns of FTH1 (Ferritin heavy chain 1) mRNA and protein. Our findings demonstrated that tumor tissues in HCC patients promote liver cancer progression by downregulating FTH1 protein expression, rather than upregulating FTH1 mRNA expression, ultimately leading to poor prognosis. Subsequently, based on risk score and tumor size, we developed a nomogram for predicting the prognosis of HCC patients, which demonstrated superior predictive performance in both the training and validation cohorts (C-index: 0.774; AUC for 1\u20135\u00a0years: 0.783\u20130.964). Additionally, our findings demonstrated that the adverse prognosis of high-risk HCC patients was closely correlated with ferroptosis in liver cancer tissues, alterations in iron metabolism, and changes in the tumor immune microenvironment. In conclusion, our prognostic model and predictive nomogram offer novel insights and tools for the effective classification of HCC patients, potentially enhancing clinical decision-making and outcomes.<\/jats:p>","DOI":"10.1093\/bib\/bbaf216","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T20:55:28Z","timestamp":1747515328000},"source":"Crossref","is-referenced-by-count":2,"title":["A novel prognostic framework for HBV-infected hepatocellular carcinoma: insights from ferroptosis and iron metabolism proteomics"],"prefix":"10.1093","volume":"26","author":[{"given":"Zhiwei","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,","place":["China"]},{"name":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]}]},{"given":"Yongyong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,","place":["China"]}]},{"given":"Xinbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]}]},{"given":"Yuening","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]}]},{"given":"Yingqi","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , 100 Haining Road, Hongkou District, Shanghai 200080,","place":["China"]}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Yale University , 300 George Street, New Haven, CT 06511 ,","place":["United States"]}]},{"given":"Hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, Shanghai Jiao Tong University , 800 Dongchuan Road, Minhang District, Shanghai 200240 ,","place":["China"]},{"name":"Institute of Bioinformatics, Shanghai Academy of Experimental Medicine , 528 Hongshan Road, Pudong New District, Shanghai 200126 ,","place":["China"]},{"name":"Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, Center for Biomedical Informatics, Shanghai Children\u2019s Hospital, School of Medicine, Shanghai Jiao Tong University , 1400 Beijing West Road, Jing'an District, Shanghai 200040 ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"key":"2025052712045928800_ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"2025052712045928800_ref2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2025052712045928800_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00818-8","article-title":"Hepatocellular carcinoma surveillance\u2014utilization, barriers and the impact of changing aetiology","volume":"20","author":"Huang","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2025052712045928800_ref4","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-019-0987-8","article-title":"Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma","volume":"567","author":"Jiang","year":"2019","journal-title":"Nature"},{"key":"2025052712045928800_ref5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3760\/cma.j.cn112152-20201109-00970","volume-title":"Guideline for Stratified Screening and Surveillance of Primary Liver Cancer (2020 Edition), Zhonghua Gan Zang Bing Za Zhi [Chinese Journal of Hepatology]","author":"Professional Committee for Prevention and Control of Hepatobiliary and Pancreatic Diseases of Chinese Preventive Medicine Association CoHoCRHA, Society of Hepatology of Chinese Medical Association, Prevention of Infection Related Cancer (PIRCA) Group","year":"2021"},{"key":"2025052712045928800_ref6","doi-asserted-by":"publisher","first-page":"bbac601","DOI":"10.1093\/bib\/bbac601","article-title":"HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol","volume":"24","author":"Cheng","year":"2023","journal-title":"Brief Bioinform"},{"key":"2025052712045928800_ref7","doi-asserted-by":"crossref","first-page":"e1323","DOI":"10.1016\/j.cell.2017.05.046","article-title":"Comprehensive and integrative genomic characterization of hepatocellular carcinoma","volume":"169","author":"Ally","year":"2017","journal-title":"Cell"},{"key":"2025052712045928800_ref8","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.cell.2019.08.052","article-title":"Integrated proteogenomic characterization of HBV-related hepatocellular carcinoma","volume":"179","author":"Gao","year":"2019","journal-title":"Cell"},{"key":"2025052712045928800_ref9","doi-asserted-by":"publisher","first-page":"101315","DOI":"10.1016\/j.xcrm.2023.101315","article-title":"Integrated omics landscape of hepatocellular carcinoma suggests proteomic subtypes for precision therapy","volume":"4","author":"Xing","year":"2023","journal-title":"Cell reports medicine"},{"key":"2025052712045928800_ref10","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41568-022-00446-5","article-title":"Cancer proteogenomics: Current impact and future prospects","volume":"22","author":"Mani","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"2025052712045928800_ref11","doi-asserted-by":"publisher","first-page":"108787","DOI":"10.1016\/j.celrep.2021.108787","article-title":"Proteogenomics of glioblastoma associates molecular patterns with survival","volume":"34","author":"Yanovich-Arad","year":"2021","journal-title":"Cell Rep"},{"key":"2025052712045928800_ref12","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nature13438","article-title":"Proteogenomic characterization of human colon and rectal cancer","volume":"513","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"2025052712045928800_ref13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-03573-6","article-title":"Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression","volume":"9","author":"Latonen","year":"2018","journal-title":"Nat Commun"},{"key":"2025052712045928800_ref14","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol Cell Biol"},{"key":"2025052712045928800_ref15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2019.12.023","article-title":"Quantitative proteomics of the cancer cell line encyclopedia","volume":"180","author":"Nusinow","year":"2020","journal-title":"Cell"},{"key":"2025052712045928800_ref16","doi-asserted-by":"publisher","first-page":"8681","DOI":"10.1038\/s41598-023-35796-z","article-title":"Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in hepatocellular carcinoma","volume":"13","author":"Li","year":"2023","journal-title":"Sci Rep"},{"key":"2025052712045928800_ref17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-021-02420-x","article-title":"FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis","volume":"21","author":"Hu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"2025052712045928800_ref18","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12943-024-02030-x","article-title":"CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p\/NUPR1\/FTH1 axis","volume":"23","author":"Zhang","year":"2024","journal-title":"Mol Cancer"},{"key":"2025052712045928800_ref19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s12672-023-00756-6","article-title":"Identification of hepatocellular carcinoma-related subtypes and development of a prognostic model: A study based on ferritinophagy-related genes","volume":"14","author":"Wang","year":"2023","journal-title":"Discover Oncology"},{"key":"2025052712045928800_ref20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jaut.2007.11.003","article-title":"New functions for an iron storage protein: The role of ferritin in immunity and autoimmunity","volume":"30","author":"Recalcati","year":"2008","journal-title":"J Autoimmun"},{"key":"2025052712045928800_ref21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.bi.56.070187.001445","article-title":"Ferritin: Structure, gene regulation, and cellular function in animals, plants, and microorganisms","volume":"56","author":"Theil","year":"1987","journal-title":"Annu Rev Biochem"},{"key":"2025052712045928800_ref22","doi-asserted-by":"publisher","first-page":"589","DOI":"10.3390\/microorganisms8040589","article-title":"Ferritin: An inflammatory player keeping iron at the core of pathogen-host interactions","volume":"8","author":"Moreira","year":"2020","journal-title":"Microorganisms"},{"key":"2025052712045928800_ref23","doi-asserted-by":"publisher","first-page":"102778","DOI":"10.1016\/j.jaut.2021.102778","article-title":"Ferritin\u2013from iron, through inflammation and autoimmunity, to COVID-19","volume":"126","author":"Mahroum","year":"2022","journal-title":"J Autoimmun"},{"key":"2025052712045928800_ref24","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: The role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2025052712045928800_ref25","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.3390\/ijms19051545","article-title":"Alterations in cellular iron metabolism provide more therapeutic opportunities for cancer","volume":"19","author":"Zhou","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2025052712045928800_ref26","doi-asserted-by":"publisher","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","article-title":"Ferroptosis","volume":"30","author":"Tang","year":"2020","journal-title":"Curr Biol"},{"key":"2025052712045928800_ref27","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.7150\/ijbs.45050","article-title":"A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma","volume-title":"Int. J. Biol. Sci","author":"Liang","year":"2020"},{"key":"2025052712045928800_ref28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s12072-021-10248-w","article-title":"A prognostic model for hepatocellular carcinoma patients based on signature ferroptosis-related genes","volume":"16","author":"Wan","year":"2022","journal-title":"Hepatology International"},{"key":"2025052712045928800_ref29","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.ccell.2019.02.005","article-title":"The proteogenomic landscape of curable prostate cancer","volume":"35","author":"Sinha","year":"2019","journal-title":"Cancer Cell"},{"key":"2025052712045928800_ref30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12964-020-00663-1","article-title":"The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma","volume":"18","author":"Tang","year":"2020","journal-title":"Cell Communication and Signaling"},{"key":"2025052712045928800_ref31","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2025052712045928800_ref32","first-page":"2015","article-title":"BMAP: A comprehensive and reproducible biomedical data analysis platform","volume":"2024","author":"Ren","year":"2007","journal-title":"bioRxiv"},{"key":"2025052712045928800_ref33","first-page":"2014","article-title":"A package for survival analysis in S","volume":"2","author":"Therneau","year":"2015","journal-title":"R package version"},{"key":"2025052712045928800_ref34","volume-title":"Survminer. Drawing Survival Curves Using \u201cggplot2\u201d(Version 0.4. 9)","author":"Kassambara","year":"2021"},{"key":"2025052712045928800_ref35","doi-asserted-by":"publisher","first-page":"bbab260","DOI":"10.1093\/bib\/bbab260","article-title":"oncoPredict: An R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data","volume":"22","author":"Maeser","year":"2021","journal-title":"Brief Bioinform"},{"key":"2025052712045928800_ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat Commun"},{"key":"2025052712045928800_ref37","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2025052712045928800_ref38","doi-asserted-by":"publisher","first-page":"12744","DOI":"10.1074\/jbc.R117.789537","article-title":"Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways","volume":"292","author":"Rouault","year":"2017","journal-title":"J Biol Chem"},{"key":"2025052712045928800_ref39","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2025052712045928800_ref40","doi-asserted-by":"publisher","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"2025052712045928800_ref41","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"2025052712045928800_ref42","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: The role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radical Biology and Medicine"},{"key":"2025052712045928800_ref43","doi-asserted-by":"publisher","first-page":"6805","DOI":"10.1158\/1538-7445.AM2024-6805","article-title":"CD81 and CD82 in tumor infiltrating lymphocytes within the NSCLC tumor microenvironment play a crucial role in T cell activation and cytokine production","volume":"84","author":"Na","year":"2024","journal-title":"Cancer Res"},{"key":"2025052712045928800_ref44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.canlet.2014.05.016","article-title":"Tetraspanin-enriched microdomains and hepatocellular carcinoma progression","volume":"351","author":"Mazzocca","year":"2014","journal-title":"Cancer Lett"},{"key":"2025052712045928800_ref45","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1053\/j.gastro.2008.03.024","article-title":"Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma","volume":"135","author":"Mazzocca","year":"2008","journal-title":"Gastroenterology"},{"key":"2025052712045928800_ref46","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1158\/1078-0432.CCR-20-2584","article-title":"B7-H3: An attractive target for antibody-based ImmunotherapyB7-H3: An attractive target for antibody-based immunotherapy","volume":"27","author":"Kontos","year":"2021","journal-title":"Clin Cancer Res"},{"key":"2025052712045928800_ref47","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/PGP.0000000000000116","article-title":"Epithelial and tumor-associated endothelial expression of B7-H3 in cervical carcinoma: Relation with CD8:+: Intraepithelial lymphocytes, FIGO stage, and Phosphohistone H3 (PHH3) reactivity","volume":"34","author":"Brustmann","year":"2015","journal-title":"Int J Gynecol Pathol"},{"key":"2025052712045928800_ref48","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","article-title":"CD4+ T cell memory","volume":"24","author":"K\u00fcnzli","year":"2023","journal-title":"Nat Immunol"},{"key":"2025052712045928800_ref49","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1007\/s00262-019-02427-4","article-title":"Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma","volume":"68","author":"Langhans","year":"2019","journal-title":"Cancer Immunol Immunother"},{"key":"2025052712045928800_ref50","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.3748\/wjg.v27.i22.2994","article-title":"Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment","volume":"27","author":"Granito","year":"2021","journal-title":"World J Gastroenterol"},{"key":"2025052712045928800_ref51","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ccell.2018.08.004","article-title":"Proteomics, post-translational modifications, and integrative analyses reveal molecular heterogeneity within medulloblastoma subgroups","volume":"34","author":"Archer","year":"2018","journal-title":"Cancer Cell"},{"key":"2025052712045928800_ref52","doi-asserted-by":"publisher","article-title":"Autonomous self-evolving research on biomedical data: The DREAM paradigm","author":"Deng","DOI":"10.1002\/advs.202417066"},{"key":"2025052712045928800_ref53","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12943-024-01988-y","article-title":"Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC","volume":"23","author":"Chan","year":"2024","journal-title":"Mol Cancer"},{"key":"2025052712045928800_ref54","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ccell.2024.01.007","article-title":"Precision treatment in advanced hepatocellular carcinoma","volume":"42","author":"Yang","year":"2024","journal-title":"Cancer Cell"},{"key":"2025052712045928800_ref55","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00432-017-2556-6","article-title":"Metronomic capecitabine as second-line treatment for hepatocellular carcinoma after sorafenib discontinuation","volume":"144","author":"Trevisani","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"2025052712045928800_ref56","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.dld.2015.03.010","article-title":"Metronomic capecitabine as second-line treatment in hepatocellular carcinoma after sorafenib failure","volume":"47","author":"Granito","year":"2015","journal-title":"Dig Liver Dis"},{"key":"2025052712045928800_ref57","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41698-024-00693-9","article-title":"Immune-related cell death index and its application for hepatocellular carcinoma","volume":"8","author":"Sun","year":"2024","journal-title":"NPJ Precision Oncology"},{"key":"2025052712045928800_ref58","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1080\/15548627.2019.1709762","article-title":"The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target","volume":"16","author":"Xue","year":"2020","journal-title":"Autophagy"},{"key":"2025052712045928800_ref59","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/s42003-022-03397-7","article-title":"FVC as an adaptive and accurate method for filtering variants from popular NGS analysis pipelines","volume":"5","author":"Ren","year":"2022","journal-title":"Communications Biology"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/3\/bbaf216\/63216997\/bbaf216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/3\/bbaf216\/63216997\/bbaf216.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:05:12Z","timestamp":1748361912000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/doi\/10.1093\/bib\/bbaf216\/8134256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbaf216","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,5,1]]},"article-number":"bbaf216"}}