{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:45:23Z","timestamp":1775627123054,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology","award":["2023ZD0506200"],"award-info":[{"award-number":["2023ZD0506200"]}]},{"name":"Climbing Project for Medical Talent of Zhongnan Hospital of Wuhan University","award":["PDJH202406 and PDJH202205"],"award-info":[{"award-number":["PDJH202406 and PDJH202205"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370696"],"award-info":[{"award-number":["32370696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Depicting a global landscape of essential gene-targeting drugs would provide more opportunities for cancer therapy. However, a systematic investigation on drugs targeting essential genes still has not been reported. We suppose that drugs targeting cancer-type-specific essential genes would generally have less toxicity than those targeting pan-cancer essential genes. A scoring function-based strategy was developed to identify cancer-type-specific targets and drugs. The EssentialitySpecificityScore ranked the essential genes in 19 cancer types, and 1151 top genes were identified as cancer-type-specific targets. Combining target-drug interaction databases with research\/marketing status, 370 cancer-type-specific drugs were identified, bound to 100 out of all identified targets. Profiles of applied cancer types of identified targets and drugs illustrate the scoring strategy\u2019s effectiveness: most drugs apply to cancer types &amp;lt;10. Seven drugs with no previous anticancer evidence were validated in 11 lung adenocarcinoma cell lines, and lower inhibition rates (from 9.4% to 44.0%) were observed in 10 normal cell lines. This difference is statistically significant (Student\u2019s t-test, P\u2009\u2264\u2009.0001), confirming the rationality of our supposition. Our built EGKG (Essential Gene Knowledge Graph) forms a computational basis to uncover essential gene targets and drugs for specific cancer types. It is available at http:\/\/gepa.org.cn\/egkg\/. Also, our experimental result suggests that combining drugs with orthogonal essentiality may be an alternative way to improve anticancer effects while maintaining biocompatibility. The code and data are available at https:\/\/github.com\/KKINGA1\/EGKG_data_process.<\/jats:p>","DOI":"10.1093\/bib\/bbaf266","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T02:56:37Z","timestamp":1749351397000},"source":"Crossref","is-referenced-by-count":1,"title":["Systematic identification of cancer-type-specific drugs based on essential genes and validations in lung adenocarcinoma"],"prefix":"10.1093","volume":"26","author":[{"given":"Xiang","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]},{"name":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Xia","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Dong-Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Anqiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Cheng-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Hong-Tu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Hai-Xia","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, University of Electronic Science and Technology of China , 2006 Xiyuan Avenue, West Hi-Tech Zone, Chengdu 611731 ,","place":["China"]}]},{"given":"Ji-Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine , Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, 185 Donghu Road, Wuchang District, Wuhan 430071,","place":["China"]}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan University , 169 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Ge-Fei","family":"Hao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Green Pesticide , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, , 2708 South Section of Huaxi Avenue, Huaxi District, Guiyang 550025 ,","place":["China"]},{"name":"Guizhou University , Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals, , 2708 South Section of Huaxi Avenue, Huaxi District, Guiyang 550025 ,","place":["China"]}]},{"given":"Zhenshun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan University , 169 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]},{"name":"Wuhan Research Center for Infectious Diseases and Cancer , Chinese Academy of Medical Sciences, 169 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]},{"name":"Hubei Engineering Center for Infectious Disease Prevention , Control and Treatment, 169 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]},{"given":"Feng-Biao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]},{"name":"Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University , 185 Donghu Road, Wuchang District, Wuhan 430071 ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,6,8]]},"reference":[{"key":"2025060722563035900_ref1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nbt.2786","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay","year":"2014","journal-title":"Nat 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