{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T08:08:09Z","timestamp":1784448489877,"version":"3.55.0"},"reference-count":149,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Conventional drug discovery is expensive, time-consuming, and prone to failure. Artificial intelligence has become a potent substitute over the last decade, providing strong answers to challenging biological issues in this field. Among these difficulties, drug-target binding (DTB) is a key component of drug discovery techniques. In this context, drug-target affinity and drug\u2013target interaction are complementary and essential frameworks that work together to improve our comprehension of DTB dynamics. In this work, we thoroughly analyze the most recent deep learning models, popular benchmark datasets, and assessment metrics for DTB prediction. We look at the paradigm shift in the development of drug discovery research since researchers started using deep learning as a potent tool for DTB prediction. In particular, we examine how methodologies have evolved, starting with early heterogeneous network-based approaches, progressing to graph-based approaches that were widely accepted, followed by modern attention-based architectures, and finally, the most recent multimodal approaches. We also provide case studies utilizing an extensive compound library against specific protein targets implicated in critical cancer pathways to demonstrate the usefulness of these approaches. In addition to summarizing the latest developments in DTB prediction models, this review also identifies their drawbacks. It also highlights the outlook for the DTB prediction domain and future research directions. Combined, these studies present a more comprehensive view of how deep learning offers a quantitative framework for researching drug-target relationships, speeding up the identification of new drug candidates and making it easier to identify possible DTBs.<\/jats:p>","DOI":"10.1093\/bib\/bbaf491","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:53:10Z","timestamp":1756813990000},"source":"Crossref","is-referenced-by-count":18,"title":["A survey on deep learning for drug-target binding prediction: models, benchmarks, evaluation, and case studies"],"prefix":"10.1093","volume":"26","author":[{"given":"Kusal","family":"Debnath","sequence":"first","affiliation":[{"name":"Department of Computer Science, Virginia Commonwealth University , Richmond, VA 23284 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratip","family":"Rana","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Old Dominion University , Norfolk, VA 23529 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetam","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Virginia Commonwealth University , Richmond, VA 23284 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"2025092202371239100_ref1"},{"key":"2025092202371239100_ref2","volume-title":"SMARTS: A Language for Specifying Molecular Substructures"},{"key":"2025092202371239100_ref3","volume-title":"SMIRKS: Reaction SMILES"},{"key":"2025092202371239100_ref4","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2209.01712"},{"key":"2025092202371239100_ref5","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1109\/TPAMI.2021.3095381","article-title":"ProtTrans: toward understanding the language of life through self-supervised 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