{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:43:20Z","timestamp":1761666200803,"version":"build-2065373602"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FL DEPT OF HLTH BIOMED RES PGM\/J&E KING","award":["R01HL153042","R01AR079220","R35GM142701"],"award-info":[{"award-number":["R01HL153042","R01AR079220","R35GM142701"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Circadian rhythms are endogenous $\\sim $24-h cycles that significantly influence physiological and behavioral processes. These rhythms are governed by a transcriptional\u2013translational feedback loop of core circadian genes and are essential for maintaining overall health. The study of circadian rhythms has expanded into various omics datasets, necessitating accurate analytical methodology for circadian biomarker detection. Here, we introduce a novel Bayesian framework for the detection of circadian rhythms in genome-wide transcriptomic applications that is capable of incorporating prior biological knowledge and adjusting for multiple testing issue via a false discovery rate (FDR) approach. Our framework leverages a Bayesian hierarchical model and employs a reverse jump Markov chain Monte Carlo technique for model selection. Through extensive simulations, our method, BayesCircRhy, demonstrated favorable FDR control over competing methods, robustness against heavier-tailed error distributions, and better performance compared with existing approaches. The method\u2019s efficacy was further validated in two RNA-sequencing data, including a human-restricted feeding data and a mouse aging data, where it successfully identified known and novel circadian genes.<\/jats:p>","DOI":"10.1093\/bib\/bbaf552","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:56:54Z","timestamp":1759406214000},"source":"Crossref","is-referenced-by-count":0,"title":["A Bayesian framework for genome-wide circadian rhythmicity biomarker detection"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-7824","authenticated-orcid":false,"given":"Haocheng","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Biostatistics , Data Science, and Epidemiology, Augusta University, 1120 15th Street, Augusta, 30912 GA,","place":["United States"]}]},{"given":"Lingsong","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , University of Florida, 2004 Mowry Road, Gainesville, 32603 FL,","place":["United States"]}]},{"given":"Yutao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , University of Florida, 2004 Mowry Road, Gainesville, 32603 FL,","place":["United States"]}]},{"given":"Andrew J","family":"Bryant","sequence":"additional","affiliation":[{"name":"Division of Pulmonary , Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, 32603 FL,","place":["United States"]}]},{"given":"Chengguo","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry , University of Florida, 1225 Center Drive, Gainesville, 32610 FL,","place":["United States"]}]},{"given":"Karyn A","family":"Esser","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging , University of Florida, 1345 Center Drive, Gainesville, 32610 FL,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-5606","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , University of Florida, 2004 Mowry Road, Gainesville, 32603 FL,","place":["United States"]}]},{"given":"Yitong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Health Outcomes and Biomedical Informatics , University of Florida, 1889 Museum Road, Gainesville, 32611 FL,","place":["United States"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8032-4392","authenticated-orcid":false,"given":"Zhiguang","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , University of Florida, 2004 Mowry Road, Gainesville, 32603 FL,","place":["United 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