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It has revolutionized studies on cellular function and disease mechanisms, particularly in cancer and immunology. We conducted a bibliometric analysis of 1197 publications from the Web of Science (2015\u201324), focusing on publication trends, journal distribution, and keyword analysis to identify key research areas in ST. ST publications surged from 2021, with 500 papers in 2023. Five of the top 10 journals are from the Nature Publishing Group. Keyword analysis identified emerging trends like \u201ctumor microenvironment,\u201d \u201cimmune infiltration,\u201d and \u201cbiomarker,\u201d highlighting ST\u2019s expanding role in cancer and immunology. International collaboration among multidisciplinary teams is crucial for maximizing ST\u2019s potential, and understanding its trends will guide its future impact. Large language models can further enrich the results of bibliometric research, making the findings of bibliometrics more comprehensive and specific.<\/jats:p>","DOI":"10.1093\/bib\/bbaf553","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:09:46Z","timestamp":1760011786000},"source":"Crossref","is-referenced-by-count":0,"title":["Spatial transcriptomics: a bibliometric analysis with large language model on English literatures"],"prefix":"10.1093","volume":"26","author":[{"given":"Huiyang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin\u2019s Clinical Research Center for Cancer , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Breast Imaging, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin\u2019s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Service Management, School of Management, Tianjin University of Traditional Chinese Medicine , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cancer Pharmacology, Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin Medicine and Health Research Center , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yile","family":"Lin","sequence":"additional","affiliation":[{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University) , Moscow ,","place":["Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bone and Soft Tissue Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin\u2019s Clinical Research Center for Cancer , Tianjin ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital , Tianjin ,","place":["China"]},{"name":"Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin Medical University General Hospital , Tianjin 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