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This paper reviews the technical foundations of LLM agents, including their core architecture, key technologies, and collaborative modes. We explore the applications of LLM agents in multi-omics, drug development, chemical research, clinical diagnosis, and health management. The paper also analyzes the major challenges faced by LLM agents, such as the interaction and extension of their frameworks, data privacy and security, model hallucinations and interpretability, timeliness of knowledge updates, and ethical and legal risks. Furthermore, we discuss future directions, including paradigms for human-artificial intelligence collaboration and the development of open-source ecosystems and standardization. This paper aims to provide a comprehensive perspective and guidance on the advancement of LLM agents in bioinformatics and biomedicine.<\/jats:p>","DOI":"10.1093\/bib\/bbaf601","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T04:26:38Z","timestamp":1762835198000},"source":"Crossref","is-referenced-by-count":9,"title":["The rise and potential opportunities of large language model agents in bioinformatics and biomedicine"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0499-336X","authenticated-orcid":false,"given":"Tiantian","family":"Yang","sequence":"first","affiliation":[{"name":"AI for Science Interdisciplinary Research Center, School of Computer Science, Northwestern Polytechnical University , No. 1 Dongxiang Road, Xi\u2019an, 710129 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Xiao","sequence":"additional","affiliation":[{"name":"AI for Science 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