{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:52:48Z","timestamp":1766764368544,"version":"3.48.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Structural variants (SVs; \u2265 50\u00a0bp) represent a major source of genomic variation and are more likely to influence gene function and phenotypes than small-scale insertions\/deletions or single nucleotide variants. Although, many studies have characterized SVs in humans and non-human primates, lineage-specific SVs within the Pan genus remain underexplored. The only species in this genus, chimpanzee (Pan troglodytes) and bonobo (Pan paniscus), exhibit lineage-specific differences for several behavioral and physiological traits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In current study, we sought to identify and characterize lineage-specific structural variants (LSSVs) in the Pan genus using high-quality genome assemblies, thereby providing novel insights into their lineage-specific emergence and potential functional impacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We detected LSSVs using an assembly-comparison approach that leveraged high-quality genome assemblies of chimpanzee, bonobo, and human. We then mapped their genome-wide distributions and conducted functional enrichment analyses of genes impacted by these variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed substantial variation in SV abundance between the two sister species, with the chimpanzee assembly exhibiting nearly a four-fold higher SV count compared with the bonobo lineage. Genome-wide SV distribution maps revealed distinct genomic regions abundant or depleted in SVs, highlighting a marked difference in LSSV distribution across diverse genomic landscapes. Functional enrichment analysis of LSSV-impacted genes highlighted many genes related to body growth, brain function, and neurological disorders in the bonobo lineage, whereas metabolism and transcriptional regulation showed enrichment in the chimpanzee lineage. Additionally, a small subset of the SV-affected genes also corresponded to distinctive behavioral differences between the two lineages, suggesting a potential role in shaping the lineage-specific traits present within the Pan genus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bib\/bbaf631.051","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T14:14:02Z","timestamp":1765548842000},"page":"i32-i32","source":"Crossref","is-referenced-by-count":0,"title":["Genomic signatures of lineage-specific structural variants in the\n                    <i>Pan<\/i>\n                    genus"],"prefix":"10.1093","volume":"26","author":[{"given":"Aisha","family":"Yousaf","sequence":"first","affiliation":[{"name":"Government College University Faisalabad ,","place":["Pakistan"]},{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences\/China National Center for Bioinformation , Beijing ,","place":["China"]}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences\/China National Center for Bioinformation , Beijing ,","place":["China"]},{"name":"Fudan University ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2025,12,12]]},"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/Supplement_1\/i32\/65854515\/bbaf631.051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bib\/article-pdf\/26\/Supplement_1\/i32\/65854515\/bbaf631.051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:49:11Z","timestamp":1766764151000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/26\/Supplement_1\/i32\/8378020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2025,12,12]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbaf631.051","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"type":"print","value":"1467-5463"},{"type":"electronic","value":"1477-4054"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,12]]}}}