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Here, we introduce Microbiome Database of Pulmonary Diseases (MDPD), an open-access, comprehensive systemic catalog of pulmonary diseases by manually curating global studies from 2012 to 2024 (13\u00a0years). We have compiled 59 362 runs from 430 BioProjects, encompassing data from 10 body sites related to 19 pulmonary diseases and healthy groups covering 278 distinct sub-groups. MDPD enables users to analyze each BioProject and customize analysis with multiple BioProjects to identify taxonomic profiles and disease group\/sub-group specific microbial signatures. The re-analyzed intermediate Biological Observation Matrix files are provided for each BioProject for the accessibility of users for further applications, such as machine learning-based classification. Identified microbes (bacteria, fungi, viruses) in MDPD are annotated with several attributes, providing further insights into their disease-causing potential and specificity to certain diseases and body sites. MDPD is freely available at: https:\/\/bicresources.jcbose.ac.in\/ssaha4\/mdpd\/.<\/jats:p>","DOI":"10.1093\/bib\/bbag017","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:52:20Z","timestamp":1772283140000},"source":"Crossref","is-referenced-by-count":0,"title":["MDPD reveals specific microbial signatures in human pulmonary diseases"],"prefix":"10.1093","volume":"27","author":[{"given":"Paramita","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Bose Institute , EN-80, Sector-V, Bidhan Nagar, Kolkata 700091, West Bengal ,","place":["India"]}]},{"given":"Dibakar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bose Institute , EN-80, Sector-V, Bidhan Nagar, Kolkata 700091, West Bengal ,","place":["India"]}]},{"given":"Sudipto","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, 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