{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:53:48Z","timestamp":1772448828266,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["23QA1402800"],"award-info":[{"award-number":["23QA1402800"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC3400501"],"award-info":[{"award-number":["2022YFC3400501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC3400504"],"award-info":[{"award-number":["2022YFC3400504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425104"],"award-info":[{"award-number":["82425104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>RNA-based technologies have demonstrated significant potential for diverse applications, ranging from vaccination to gene editing. However, their widespread adoption is limited by the critical challenge of efficient delivery. Lipid nanoparticles (LNPs) have emerged as a widely utilized RNA delivery system, yet their formulation design and optimization primarily rely on empirical trial-and-error, which is labor-intensive, time-consuming, and cost-prohibitive, thus hindering the rapid development of RNA therapeutics. To facilitate the early-stage design and optimization of LNPs for enhanced delivery efficiency, in this study, we construct LNPs-TE, a benchmark dataset comprising over 10 000 experimentally measured transfection efficiency (TE) values, and introduce LNPs integrated feature fusion Transformer (LIFT), a deep learning framework for LNPs TE prediction. Comprehensive experiments demonstrate that LIFT effectively integrates multidimensional molecular representations of ionizable lipids, the key component in LNPs formulation, achieving superior predictive performance, with an average Pearson correlation coefficient of 0.845 for regression and an area under the receiver operating characteristic curve (AUC-ROC) of 0.818 for multi-class classification across multiple datasets. Through scaffold-based splitting and activity cliff tasks, we further validated the exceptional generalization ability and robustness of LIFT, which achieved over a 10% improvement in the coefficient of determination (R2) compared with state-of-the-art baseline models, highlighting its potential as a practical and stable approach for the virtual screening of efficient LNPs formulation. The relevant data, model and code are made publicly available at https:\/\/github.com\/U12458\/LIFT.<\/jats:p>","DOI":"10.1093\/bib\/bbag092","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:43:33Z","timestamp":1770813813000},"source":"Crossref","is-referenced-by-count":0,"title":["Transformer-based multidimensional feature fusion for accurate prediction of lipid nanoparticles transfection efficiency"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5799-5494","authenticated-orcid":false,"given":"Daohong","family":"Gong","sequence":"first","affiliation":[{"name":"School of Information Science and Technology, ShanghaiTech University , 393 Middle Huaxia Road, Pudong New Area, Shanghai 201210 ,","place":["China"]},{"name":"Lingang Laboratory , 2380 Hechuan Road, Minhang District, Shanghai 200031 ,","place":["China"]},{"name":"Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University , 3663 North Zhongshan Road, Putuo District, Shanghai 200062 ,","place":["China"]}]},{"given":"Xiaowei","family":"Xie","sequence":"additional","affiliation":[{"name":"Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University , 3663 North Zhongshan Road, Putuo District, Shanghai 200062 ,","place":["China"]}]},{"given":"Jianxin","family":"Tang","sequence":"additional","affiliation":[{"name":"Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University , 3663 North Zhongshan Road, Putuo District, Shanghai 200062 ,","place":["China"]}]},{"given":"Shiliang","family":"Li","sequence":"additional","affiliation":[{"name":"Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University , 3663 North Zhongshan Road, Putuo District, Shanghai 200062 ,","place":["China"]}]},{"given":"Honglin","family":"Li","sequence":"additional","affiliation":[{"name":"Lingang Laboratory , 2380 Hechuan Road, Minhang District, Shanghai 200031 ,","place":["China"]},{"name":"Innovation Center for AI and Drug Discovery, School of Pharmacy, East China Normal University , 3663 North Zhongshan Road, Putuo District, Shanghai 200062 ,","place":["China"]}]}],"member":"286","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026030204572381600_ref1","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021"},{"key":"2026030204572381600_ref2","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1021\/acs.molpharmaceut.0c00618","article-title":"Nanomedicine-based approaches for mRNA delivery","volume":"17","author":"Uchida","year":"2020","journal-title":"Mol Pharm"},{"key":"2026030204572381600_ref3","doi-asserted-by":"publisher","first-page":"2000099","DOI":"10.1002\/adtp.202000099","article-title":"Nanoplatforms for mRNA 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