{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:49:35Z","timestamp":1784148575538,"version":"3.55.0"},"reference-count":158,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671373"],"award-info":[{"award-number":["31671373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61971422"],"award-info":[{"award-number":["61971422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"XJTLU Key Program Special Fund","award":["KSF-T-01"],"award-info":[{"award-number":["KSF-T-01"]}]},{"name":"AI University Research Centre through XJTLU Key Programme Special Fund","award":["KSF-P-02"],"award-info":[{"award-number":["KSF-P-02"]}]},{"name":"Xi\u2019an Jiaotong\u2013Liverpool University PhD scholarship to Shuhe Liu","award":["FOSSP231101"],"award-info":[{"award-number":["FOSSP231101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N \u00a06-methyladenosine (m6A), the most prevalent internal RNA modification, is an emerging key regulator of gene expression in the central nervous system, and its dysregulation is connected to psychiatric disorders. However, disentangling the causal links between specific m6A sites and diseases phenotypes remain challenging. This review presents a comprehensive survey of practical bioinformatics strategies to address it. Our review outlines four analytical themes: (i) the reliable calibration of false-positive signals, (ii) causal inference via statistical genetics, (iii) the acquisition of cell-type-specific functional insights, and (iv) the application of machine learning to predict clinical biomarkers. We validate these analytical strategies through a case study in major depressive disorder, specifically by intersecting m6A effects with psychiatric genetic risk. By streamlining these workflows, we provide a roadmap for formulating testable hypotheses regarding epitranscriptome-targeted therapeutic interventions in psychiatric disorders.<\/jats:p>","DOI":"10.1093\/bib\/bbag251","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:37:55Z","timestamp":1778153875000},"source":"Crossref","is-referenced-by-count":1,"title":["Decoding causal m6A: a bioinformatics roadmap for psychiatric disorders"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7843-8429","authenticated-orcid":false,"given":"Shuhe","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-9614","authenticated-orcid":false,"given":"Zhen","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Institute of Life Course and Medical Sciences, University of Liverpool , 6 West Derby Street, L7 8TX Liverpool,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F","family":"Carr","sequence":"additional","affiliation":[{"name":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Crown Street, L69 7BE Liverpool ,","place":["United Kingdom"]},{"name":"Department of Pharmacology and Therapeutics, University of Liverpool , Crown Street, L69 7BE Liverpool,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Moraros","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Suzhou Municipal Key Laboratory of AI4Health , 111 Ren'ai Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123 ,","place":["China"]},{"name":"Institute of Population Health, University of Liverpool , Brownlow Street, L69 3GF Liverpool ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"2026052510354673300_ref1","doi-asserted-by":"publisher","first-page":"58R","DOI":"10.1203\/pdr.0b013e3180457635","article-title":"Epigenetic regulation of neural gene expression and neuronal function","volume":"61","author":"Feng","year":"2007","journal-title":"Pediatr Res"},{"key":"2026052510354673300_ref2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N 6-methyladenosine and gene 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