{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T14:03:55Z","timestamp":1780236235148,"version":"3.54.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Yunnan Tobacco Company","award":["2025530000241005"],"award-info":[{"award-number":["2025530000241005"]}]},{"name":"Yunnan Tobacco Company","award":["2024530000241003"],"award-info":[{"award-number":["2024530000241003"]}]},{"name":"Yunnan Tobacco Company","award":["2022530000241009"],"award-info":[{"award-number":["2022530000241009"]}]},{"name":"China National Tobacco Company","award":["110202101038"],"award-info":[{"award-number":["110202101038"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LD25C130001"],"award-info":[{"award-number":["LD25C130001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Natural Science Foundation of Zhejiang Province","award":["LD25C130001"],"award-info":[{"award-number":["LD25C130001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Quantitative trait locus (QTL) mapping is a powerful approach to uncover the genetic architecture of complex traits. Traditional biparental populations, though widely used, offer limited genetic diversity and resolution, making them less effective for robust genetic architecture dissection. In contrast, multiparent advanced generation intercross (MAGIC) populations possess more allelic diversity, enabling the detection of intricate gene interactions including dominance and epistasis in QTL mapping. However, QTL mapping in MAGIC populations encounters some great challenges, particularly in inferring parental origin of QTL and estimating their effects unbiasedly. We tackled these challenges by developing a novel QTL mapping method for pure-line MAGIC populations, accompanied by the software QTLNetwork-MP. This method extends the mixed linear model framework by integrating a Markov chain-based algorithm and orthogonal QTL effect decomposition. This allows for the estimation of QTL effects, including additive and additive\u2013additive epistasis as well as environmental interactions for MAGIC populations derived from four-way or eight-way crosses. Simulation studies show that QTLNetwork-MP achieves high statistical power and well-controlled false discovery rates across varying heritability, population size, and parent number. We applied QTLNetwork-MP to map QTLs for seed size in an eight-parent recombinant inbred line MAGIC cowpea population, identifying three significant additive QTLs and accurately estimating their genetic effects, validating the value of the method in practical application.<\/jats:p>","DOI":"10.1093\/bib\/bbag273","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:21:19Z","timestamp":1778498479000},"source":"Crossref","is-referenced-by-count":0,"title":["QTLNetwork-MP: integrative mapping of additive, epistatic, and G\u2009\u00d7\u2009E effects for complex traits in multiparent advanced generation intercross populations"],"prefix":"10.1093","volume":"27","author":[{"given":"Tian- Neng","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Department of Pathology, School of Medicine, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Tong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tobacco Biotechnological Breeding, National Tobacco Genetic Engineering Research Center, Yunnan Academy of Tobacco Agricultural Sciences , 33 Yuantong Road, Wuhua Distrct, Kunming, Yunnan 650021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhe","family":"Suo","sequence":"additional","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzi","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asad","family":"Ullah","sequence":"additional","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingguang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tobacco Biotechnological Breeding, National Tobacco Genetic Engineering Research Center, Yunnan Academy of Tobacco Agricultural Sciences , 33 Yuantong Road, Wuhua Distrct, Kunming, Yunnan 650021 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-4087","authenticated-orcid":false,"given":"Hai-Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Crop Science, College of Agriculture and Biotechnology, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]},{"name":"Institute of Bioinformatics, Zhejiang University , 866 Yuhangtang Road, Xihu District, Hangzhou, Zhejiang 310058 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"2026053109464512700_ref1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/genetics\/121.1.185","article-title":"Mapping mendelian factors underlying quantitative traits using 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