{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:18:31Z","timestamp":1779358711581,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Briefings in Bioinformatics"],"DOI":"10.1093\/bib\/bbn026","type":"journal-article","created":{"date-parts":[[2008,6,23]],"date-time":"2008-06-23T20:27:11Z","timestamp":1214252831000},"page":"404-421","source":"Crossref","is-referenced-by-count":52,"title":["A structured approach for the engineering of biochemical network models, illustrated for signalling pathways"],"prefix":"10.1093","volume":"9","author":[{"given":"R.","family":"Breitling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Heiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Orton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,4,24]]},"reference":[{"issue":"4","key":"2_29022238","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1093\/bib\/bbm029","volume":"8","year":"2007","journal-title":"Briefings in Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"issue":"11","key":"3_29854775","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/nbt1356","volume":"25","author":"Fisher","year":"2007","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"5","key":"4_14572096","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/bioinformatics\/9.5.563","volume":"9","author":"Mendes","year":"1993","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"6_30608100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/3-540-36481-1_11","volume":"2602","year":"2003","journal-title":"LECT NOTES COMPUT SCI"},{"issue":"Pt 2","key":"7_19646215","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1042\/BJ20050908","volume":"392","author":"Orton","year":"2005","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"4","key":"8_16983683","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1038\/nbt0402-370","volume":"20","author":"Schoeberl","year":"2002","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"8","key":"9_18732592","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1016\/j.febslet.2005.02.002","volume":"579","author":"Kolch","year":"2005","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"issue":"28","key":"10_19645892","doi-asserted-by":"publisher","first-page":"6289","DOI":"10.1016\/j.febslet.2005.10.034","volume":"579","author":"Breitling","year":"2005","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"issue":"1","key":"11_17454622","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0962-8924(02)00009-0","volume":"13","author":"Wiley","year":"2003","journal-title":"Trends in cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/0962-8924","issn-type":"print"},{"issue":"19","key":"12_16408209","doi-asserted-by":"publisher","first-page":"10078","DOI":"10.1073\/pnas.93.19.10078","volume":"93","author":"Huang","year":"1996","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"13_31635479","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1021\/bi970535d","volume":"36","year":"1997","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2960","issn-type":"print"},{"issue":"42","key":"14_10991884","doi-asserted-by":"publisher","first-page":"30169","DOI":"10.1074\/jbc.274.42.30169","volume":"274","author":"Kholodenko","year":"1999","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"15_31344599","first-page":"169","volume":"482","year":"2003","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"key":"16_31344600","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1049\/sb:20045009","volume":"1","year":"2004","journal-title":"SYST BIOL STEVENAGE"},{"issue":"11","key":"17_10326902","doi-asserted-by":"publisher","first-page":"5818","DOI":"10.1073\/pnas.97.11.5818","volume":"97","author":"Levchenko","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"6","key":"18_6506304","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1046\/j.1432-1327.2000.01197.x","volume":"267","author":"Kholodenko","year":"2000","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"issue":"3-4","key":"19_19451094","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1088\/1478-3967\/1\/3\/006","volume":"1","author":"Brown","year":"2004","ISSN":"https:\/\/id.crossref.org\/issn\/1478-3967","issn-type":"print"},{"key":"20_31344601","first-page":"1113","volume":"314","year":"2003","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"key":"26_31344602","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1109\/5.24143","volume":"77","year":"1989","journal-title":"IN PROCEEDING OF IEEE"},{"issue":"6","key":"33_22258783","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nbt0606-667","volume":"24","author":"Alves","year":"2006","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"4","key":"34_17519775","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/bioinformatics\/btg015","volume":"19","author":"Hucka","year":"2003","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"24","key":"36_22776721","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/bioinformatics\/btl485","volume":"22","year":"2006","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"37_24568898","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1137\/S1064827594276424","volume":"18","year":"1997","journal-title":"SIAM J SCI COMPUT"},{"issue":"20","key":"39_29411766","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1093\/bioinformatics\/btm416","volume":"23","year":"2007","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/9\/5\/404\/743777\/bbn026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T04:15:37Z","timestamp":1549944937000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article-lookup\/doi\/10.1093\/bib\/bbn026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,24]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,4,24]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbn026","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,24]]}}}