{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:06:28Z","timestamp":1779296788080,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Briefings in Bioinformatics"],"published-print":{"date-parts":[[2011,7,1]]},"DOI":"10.1093\/bib\/bbr021","type":"journal-article","created":{"date-parts":[[2011,4,20]],"date-time":"2011-04-20T01:23:50Z","timestamp":1303262630000},"page":"346-356","source":"Crossref","is-referenced-by-count":190,"title":["Drug repositioning for orphan diseases"],"prefix":"10.1093","volume":"12","author":[{"given":"D.","family":"Sardana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Gudivada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Jegga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,4,18]]},"reference":[{"issue":"8","key":"1_18279014","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nrd1468","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nature reviews. Drug discovery","ISSN":"https:\/\/id.crossref.org\/issn\/1474-1776","issn-type":"print"},{"issue":"5933","key":"2_35038217","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1126\/science.1169920","volume":"324","author":"Boguski","year":"2009","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"1","key":"3_36637855","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1358\/dnp.2010.23.1.1440373","volume":"23","author":"Graul","year":"2010","journal-title":"Drug news & perspectives","ISSN":"https:\/\/id.crossref.org\/issn\/0214-0934","issn-type":"print"},{"issue":"4","key":"4_37598236","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cbpa.2010.06.166","volume":"14","author":"Metz","year":"2010","journal-title":"Current opinion in chemical biology","ISSN":"https:\/\/id.crossref.org\/issn\/1367-5931","issn-type":"print"},{"issue":"3","key":"5_37237674","first-page":"297","volume":"13","author":"Boran","year":"2010","journal-title":"Current opinion in drug discovery & development","ISSN":"https:\/\/id.crossref.org\/issn\/1367-6733","issn-type":"print"},{"issue":"3","key":"6_36625508","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tips.2009.11.006","volume":"31","author":"Pujol","year":"2010","journal-title":"Trends in Pharmacological Sciences (Regular ed.)","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3735","issn-type":"print"},{"issue":"2","key":"7_15968162","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0022-3565(25)10548-X","volume":"274","author":"Thor","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"issue":"6","key":"9_17965608","first-page":"10","volume":"37","author":"Rados","year":"2003","journal-title":"FDA consumer","ISSN":"https:\/\/id.crossref.org\/issn\/0362-1332","issn-type":"print"},{"issue":"1","key":"10_22324561","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1365-2796.2006.01666.x","volume":"260","author":"Wastfelt","year":"2006","journal-title":"Journal of internal medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0954-6820","issn-type":"print"},{"issue":"suppl_1","key":"13_38536813","doi-asserted-by":"publisher","first-page":"D1060","DOI":"10.1093\/nar\/gkq1037","volume":"39","year":"2011","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"14_39555890","first-page":"116","volume":"7","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1613-4516","issn-type":"print"},{"issue":"33","key":"15_37777862","doi-asserted-by":"publisher","first-page":"14621","DOI":"10.1073\/pnas.1000138107","volume":"107","year":"2010","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"12","key":"16_19507452","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/nrd1900","volume":"4","author":"Brophy","year":"2005","journal-title":"Nature reviews. Drug discovery","ISSN":"https:\/\/id.crossref.org\/issn\/1474-1776","issn-type":"print"},{"key":"17_34619614","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cmdc.200700139","volume":"3","year":"2008","journal-title":"CHEM MED CHEM"},{"issue":"23","key":"18_29936488","doi-asserted-by":"publisher","first-page":"11359","DOI":"10.1158\/0008-5472.CAN-07-2235","volume":"67","author":"Lee","year":"2007","journal-title":"Cancer Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"8","key":"19_38292653","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.4161\/auto.6.8.13551","volume":"6","author":"Iorio","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1554-8635","issn-type":"print"},{"issue":"7270","key":"20_35906975","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nature08506","volume":"462","author":"Keiser","year":"2009","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"7","key":"21_35241929","doi-asserted-by":"publisher","first-page":"e1000423","DOI":"10.1371\/journal.pcbi.1000423","volume":"5","author":"Kinnings","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"5","key":"22_34860522","doi-asserted-by":"publisher","first-page":"e1000387","DOI":"10.1371\/journal.pcbi.1000387","volume":"5","author":"Xie","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"5","key":"23_17611431","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrg1065","volume":"4","author":"Stein","year":"2003","journal-title":"Nature reviews. Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"6832","key":"24_11129062","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/35074206","volume":"410","author":"Berners-Lee","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"4","key":"25_34884588","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1093\/bib\/bbp024","volume":"10","year":"2009","journal-title":"Briefings in Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"issue":"2","key":"26_34124178","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/bib\/bbn056","volume":"10","year":"2009","journal-title":"Briefings in Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"key":"27_35647566","first-page":"S4","volume":"10","year":"2009","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"5","key":"28_31817933","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jbi.2008.07.004","volume":"41","author":"Gudivada","year":"2008","journal-title":"Journal of biomedical informatics","ISSN":"https:\/\/id.crossref.org\/issn\/1532-0464","issn-type":"print"},{"key":"29_37319013","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/1471-2105-11-255","volume":"11","author":"Chen","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"5","key":"30_32278049","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jbi.2008.03.004","volume":"41","author":"Belleau","year":"2008","journal-title":"Journal of biomedical informatics","ISSN":"https:\/\/id.crossref.org\/issn\/1532-0464","issn-type":"print"},{"issue":"10","key":"32_29590947","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nbt1338","volume":"25","author":"Y\u00a0\u00a0ld\u00a0\u00a0r\u00a0\u00a0m","year":"2007","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"6833","key":"33_11137147","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/35075138","volume":"411","author":"Jeong","year":"2001","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"4","key":"34_28461484","doi-asserted-by":"publisher","first-page":"e59","DOI":"10.1371\/journal.pcbi.0030059","volume":"3","author":"Yu","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"key":"35_38209257","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1186\/1471-2105-11-484","volume":"11","author":"Florez","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"key":"36_30714717","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/msb.2008.15","volume":"4","author":"Chavali","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1744-4292","issn-type":"print"},{"key":"37_34254414","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1752-0509-2-109","volume":"2","author":"Raman","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1752-0509","issn-type":"print"},{"issue":"3","key":"38_36797340","doi-asserted-by":"publisher","first-page":"e9568","DOI":"10.1371\/journal.pone.0009568","volume":"5","author":"Yang","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"7","key":"39_37741306","doi-asserted-by":"publisher","first-page":"e11764","DOI":"10.1371\/journal.pone.0011764","volume":"5","author":"Zhao","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"suppl_1","key":"40_29934971","doi-asserted-by":"publisher","first-page":"D901","DOI":"10.1093\/nar\/gkm958","volume":"36","year":"2008","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"11","key":"41_32314373","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nchembio.118","volume":"4","author":"Hopkins","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1552-4450","issn-type":"print"},{"issue":"10","key":"42_29590943","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"19","key":"43_35350781","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1093\/bioinformatics\/btp465","volume":"25","year":"2009","journal-title":"Bioinformatics","ISSN":"https:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"2","key":"44_23636702","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nbt1284","volume":"25","author":"Keiser","year":"2007","journal-title":"Nature biotechnology","ISSN":"https:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"9","key":"45_38349907","doi-asserted-by":"publisher","first-page":"e1000938","DOI":"10.1371\/journal.pcbi.1000938","volume":"6","author":"Chang","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"8","key":"46_38068724","doi-asserted-by":"publisher","first-page":"e12063","DOI":"10.1371\/journal.pone.0012063","volume":"5","author":"Wallach","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"3","key":"47_39706415","doi-asserted-by":"publisher","first-page":"e1002016","DOI":"10.1371\/journal.pcbi.1002016","volume":"7","author":"Yang","year":"2011","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"7","key":"48_35330766","doi-asserted-by":"publisher","first-page":"e1000441","DOI":"10.1371\/journal.pcbi.1000441","volume":"5","author":"Yang","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"11","key":"49_30038122","doi-asserted-by":"publisher","first-page":"e217","DOI":"10.1371\/journal.pcbi.0030217","volume":"3","author":"Xie","year":"2007","ISSN":"https:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"12","key":"50_32817581","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1021\/ci800079x","volume":"48","author":"Nigsch","year":"2008","journal-title":"Journal of chemical information and modeling","ISSN":"https:\/\/id.crossref.org\/issn\/1549-9596","issn-type":"print"},{"key":"51_36483553","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/msb.2009.98","volume":"6","author":"Kuhn","year":"2010","ISSN":"https:\/\/id.crossref.org\/issn\/1744-4292","issn-type":"print"},{"issue":"5886","key":"52_31453211","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1126\/science.1158140","volume":"321","author":"Campillos","year":"2008","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"17","key":"53_9160847","doi-asserted-by":"publisher","first-page":"6644","DOI":"10.1073\/pnas.87.17.6644","volume":"87","author":"DesJarlais","year":"1990","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"suppl_2","key":"54_31158317","doi-asserted-by":"publisher","first-page":"W55","DOI":"10.1093\/nar\/gkn307","volume":"36","year":"2008","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"20","key":"55_9439454","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1056\/NEJM199105163242002","volume":"324","author":"Warrell","year":"1991","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"7021","key":"56_18645425","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nature03180","volume":"433","author":"Rothstein","year":"2005","journal-title":"Nature; Physical Science (London)","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"4467","key":"57_8217042","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.6775372","volume":"210","author":"Bacchi","year":"1980","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"9","key":"58_11311817","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1177\/00912700122010951","volume":"41","author":"Malhotra","year":"2001","journal-title":"The Journal of Clinical Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9754","issn-type":"print"},{"issue":"7-8","key":"60_29041174","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.biocel.2007.01.022","volume":"39","author":"Melchert","year":"2007","journal-title":"The international journal of biochemistry & cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/1357-2725","issn-type":"print"},{"key":"61_39736241","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/009286150804200108","volume":"42","year":"2008","journal-title":"Drug information journal","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8615","issn-type":"print"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/12\/4\/346\/664071\/bbr021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T04:44:22Z","timestamp":1741149862000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article-lookup\/doi\/10.1093\/bib\/bbr021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,18]]},"references-count":56,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,7,17]]},"published-print":{"date-parts":[[2011,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbr021","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,18]]}}}