{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:40:54Z","timestamp":1760708454707},"reference-count":153,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Briefings in Bioinformatics"],"published-print":{"date-parts":[[2012,7,1]]},"DOI":"10.1093\/bib\/bbs026","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T08:00:25Z","timestamp":1343203225000},"page":"430-445","source":"Crossref","is-referenced-by-count":18,"title":["Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities"],"prefix":"10.1093","volume":"13","author":[{"given":"C. F.","family":"Quo","sequence":"first","affiliation":[]},{"given":"C.","family":"Kaddi","sequence":"additional","affiliation":[]},{"given":"J. H.","family":"Phan","sequence":"additional","affiliation":[]},{"given":"A.","family":"Zollanvari","sequence":"additional","affiliation":[]},{"given":"M.","family":"Xu","sequence":"additional","affiliation":[]},{"given":"M. D.","family":"Wang","sequence":"additional","affiliation":[]},{"given":"G.","family":"Alterovitz","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"issue":"6632 Suppl","key":"1_16797019","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/387067a0","volume":"387","author":"Cherry","year":"1997","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"suppl_1","key":"2_35971294","doi-asserted-by":"publisher","first-page":"D463","DOI":"10.1093\/nar\/gkp952","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"3","key":"3_17520565","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nrm1054","volume":"4","author":"Hunter","year":"2003","journal-title":"Nature reviews. Molecular cell biology","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0072","issn-type":"print"},{"issue":"7191","key":"4_31013095","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature06862","volume":"453","author":"Kidd","year":"2008","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"17","key":"5_37682229","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1002\/pmic.201000220","volume":"10","author":"Rabilloud","year":"2010","journal-title":"Proteomics","ISSN":"http:\/\/id.crossref.org\/issn\/1615-9853","issn-type":"print"},{"issue":"suppl_1","key":"6_32319075","doi-asserted-by":"publisher","first-page":"D555","DOI":"10.1093\/nar\/gkn788","volume":"37","year":"2009","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"6804","key":"7_10511284","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/35036627","volume":"407","author":"Jeong","year":"2000","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"2","key":"8_31436386","doi-asserted-by":"publisher","first-page":"026113","DOI":"10.1063\/1.2945228","volume":"18","author":"Kaluza","year":"2008","journal-title":"Chaos (Woodbury, N.Y.)","ISSN":"http:\/\/id.crossref.org\/issn\/1054-1500","issn-type":"print"},{"issue":"5900","key":"9_32209814","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1126\/science.1160617","volume":"322","author":"Brandman","year":"2008","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"5560","key":"10_16939205","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1069492","volume":"295","author":"Kitano","year":"2002","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"10","key":"11_10310924","doi-asserted-by":"publisher","first-page":"5031","DOI":"10.1073\/pnas.97.10.5031","volume":"97","author":"Lauffenburger","year":"2000","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"12_37799069","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1186\/1471-2105-11-408","volume":"11","author":"Campain","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"key":"13_22078524","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/1471-2105-7-247","volume":"7","author":"Conlon","year":"2006","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"key":"14_43269577","first-page":"869093","volume":"2009","year":"2009","journal-title":"Human Genomics and Proteomics","ISSN":"http:\/\/id.crossref.org\/issn\/1757-4242","issn-type":"print"},{"key":"15_43269578","first-page":"EL_13_3_13","volume":"13","year":"2006","journal-title":"ENGINEER LETT"},{"issue":"25","key":"16_19686573","doi-asserted-by":"publisher","first-page":"9309","DOI":"10.1073\/pnas.0401994101","volume":"101","year":"2004","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"3","key":"17_31140804","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jtbi.2007.09.043","volume":"252","author":"Behre","year":"2008","journal-title":"Journal of Theoretical Biology","ISSN":"http:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"key":"18_33453621","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1209\/epl\/i1998-00199-0","volume":"41","year":"1998","journal-title":"Europhysics Letters","ISSN":"http:\/\/id.crossref.org\/issn\/0295-5075","issn-type":"print"},{"issue":"2","key":"19_39229433","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1089\/cmb.2010.0215","volume":"18","author":"Quo","year":"2011","journal-title":"Journal of computational biology : a journal of computational molecular cell biology","ISSN":"http:\/\/id.crossref.org\/issn\/1066-5277","issn-type":"print"},{"issue":"3","key":"20_11623829","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0022-5193(69)80026-3","volume":"25","author":"Savageau","year":"1969","journal-title":"Journal of Theoretical Biology","ISSN":"http:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"issue":"9","key":"22_6567282","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1073\/pnas.97.9.4649","volume":"97","author":"Yi","year":"2000","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"8","key":"23_36710012","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1093\/nar\/gkq123","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"5","key":"24_34678049","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nbt.1536","volume":"27","author":"Ellis","year":"2009","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"1","key":"25_35737905","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/bit.22575","volume":"105","author":"Foley","year":"2010","journal-title":"Biotechnology and Bioengineering","ISSN":"http:\/\/id.crossref.org\/issn\/1097-0290","issn-type":"print"},{"issue":"2","key":"26_36341702","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cbpa.2009.11.023","volume":"14","author":"Lopez-Gallego","year":"2010","journal-title":"Current opinion in chemical biology","ISSN":"http:\/\/id.crossref.org\/issn\/1367-5931","issn-type":"print"},{"key":"27_43269579","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1754-1611-4-1","volume":"4","year":"2010","journal-title":"J BIOL ENGINEER"},{"issue":"7257","key":"28_35343570","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature08187","volume":"460","author":"Wang","year":"2009","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"5235","key":"29_16038749","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.270.5235.467","volume":"270","author":"Schena","year":"1995","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"4","key":"30_36213379","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1093\/bioinformatics\/btp692","volume":"26","year":"2010","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"6","key":"31_37281179","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nrm2900","volume":"11","author":"Choudhary","year":"2010","journal-title":"Nature reviews. Molecular cell biology","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0072","issn-type":"print"},{"issue":"7208","key":"32_31634316","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature07211","volume":"454","author":"Bennett","year":"2008","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"34_41030990","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2144\/03351bm03","volume":"35","year":"2003","ISSN":"http:\/\/id.crossref.org\/issn\/1940-9818","issn-type":"print"},{"issue":"4","key":"35_16912964","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","volume":"30","author":"Yang","year":"2002","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"2","key":"36_18392631","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.ab.2004.05.010","volume":"331","author":"Cox","year":"2004","journal-title":"Analytical biochemistry","ISSN":"http:\/\/id.crossref.org\/issn\/0003-2697","issn-type":"print"},{"issue":"5","key":"37_17086108","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0168-9525(02)02665-3","volume":"18","author":"Nadon","year":"2002","journal-title":"Trends in genetics : TIG","ISSN":"http:\/\/id.crossref.org\/issn\/0168-9525","issn-type":"print"},{"issue":"6","key":"38_28772331","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1007\/s10439-007-9313-y","volume":"35","author":"Stokes","year":"2007","journal-title":"Annals of biomedical engineering","ISSN":"http:\/\/id.crossref.org\/issn\/0090-6964","issn-type":"print"},{"issue":"6","key":"39_35196006","doi-asserted-by":"publisher","first-page":"e1000369","DOI":"10.1371\/journal.pcbi.1000369","volume":"5","author":"Richter","year":"2009","ISSN":"http:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"issue":"3","key":"40_30280755","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tig.2007.12.006","volume":"24","author":"Klipcan","year":"2008","journal-title":"Trends in genetics : TIG","ISSN":"http:\/\/id.crossref.org\/issn\/0168-9525","issn-type":"print"},{"key":"41_43269580","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jbi.2009.11.003","volume":"43","year":"2010","journal-title":"J BIOM INFORM"},{"issue":"5","key":"42_37263155","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/bib\/bbq015","volume":"11","year":"2010","journal-title":"Briefings in Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"issue":"3","key":"43_36106965","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/bioinformatics\/btp666","volume":"26","year":"2010","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"8","key":"44_34134406","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/bioinformatics\/btp113","volume":"25","year":"2009","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"14","key":"45_37035426","doi-asserted-by":"publisher","first-page":"4570","DOI":"10.1093\/nar\/gkq211","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"4","key":"46_20030001","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1101\/gr.229202. Article published online before March 2002","volume":"12","year":"2002","journal-title":"Genome Research","ISSN":"http:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"issue":"9","key":"47_34299132","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","year":"2009","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"48_43269581","doi-asserted-by":"crossref","first-page":"U909","DOI":"10.1038\/nmeth.1517","volume":"7","year":"2010","ISSN":"http:\/\/id.crossref.org\/issn\/1548-7091","issn-type":"print"},{"issue":"7","key":"49_39941153","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nbt.1883","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"9","key":"50_35479683","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrg2633","volume":"10","author":"Gstaiger","year":"2009","journal-title":"Nature reviews. Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"12","key":"51_34604636","doi-asserted-by":"publisher","first-page":"5230","DOI":"10.1021\/pr8005777","volume":"7","author":"Deininger","year":"2008","journal-title":"Journal of proteome research","ISSN":"http:\/\/id.crossref.org\/issn\/1535-3893","issn-type":"print"},{"key":"52_43269582","doi-asserted-by":"crossref","first-page":"I230","DOI":"10.1093\/bioinformatics\/btr246","volume":"27","year":"2011","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"10","key":"53_35450431","doi-asserted-by":"publisher","first-page":"4876","DOI":"10.1021\/pr900522m","volume":"8","author":"Djidja","year":"2009","journal-title":"Journal of proteome research","ISSN":"http:\/\/id.crossref.org\/issn\/1535-3893","issn-type":"print"},{"key":"54_37631816","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/1476-4598-9-186","volume":"9","author":"Liu","year":"2010","journal-title":"Molecular cancer [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4598","issn-type":"print"},{"issue":"4","key":"55_36707233","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1021\/pr901008d","volume":"9","author":"Rauser","year":"2010","journal-title":"Journal of proteome research","ISSN":"http:\/\/id.crossref.org\/issn\/1535-3893","issn-type":"print"},{"issue":"1","key":"56_38511199","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1021\/ac101565f","volume":"83","author":"Greving","year":"2011","journal-title":"Analytical Chemistry (Washington, DC)","ISSN":"http:\/\/id.crossref.org\/issn\/1520-6882","issn-type":"print"},{"issue":"8","key":"57_31365379","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1021\/pr800214d","volume":"7","author":"McDonnell","year":"2008","journal-title":"Journal of proteome research","ISSN":"http:\/\/id.crossref.org\/issn\/1535-3893","issn-type":"print"},{"key":"58_43269583","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/mas.20104","volume":"26","year":"2007","journal-title":"MASS SPECTROMETRY REV"},{"issue":"3","key":"59_36831160","doi-asserted-by":"publisher","first-page":"e9182","DOI":"10.1371\/journal.pone.0009182","volume":"5","author":"Luo","year":"2010","ISSN":"http:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"4","key":"60_11417313","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/ng1201-365","volume":"29","author":"Brazma","year":"2001","journal-title":"Nature genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"8","key":"61_31686365","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nbt.1411","volume":"26","author":"Taylor","year":"2008","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"9","key":"62_18421780","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.tplants.2004.07.004","volume":"9","author":"Bino","year":"2004","journal-title":"Trends in plant science","ISSN":"http:\/\/id.crossref.org\/issn\/1360-1385","issn-type":"print"},{"issue":"12","key":"64_19744266","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1038\/nbt1156","volume":"23","author":"Nov\u00a0\u00a0re","year":"2005","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"4","key":"65_39885357","doi-asserted-by":"publisher","first-page":"e1001122","DOI":"10.1371\/journal.pcbi.1001122","volume":"7","author":"Waltemath","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1553-734X","issn-type":"print"},{"key":"66_43269584","first-page":"159","volume":"3","year":"2004","journal-title":"DDT TARGETS"},{"key":"68_43269585","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1752-0509-1-58","volume":"1","year":"2007","journal-title":"BMC SYS BIOL"},{"key":"69_41838155","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.patrec.2009.09.011","volume":"31","year":"2010","ISSN":"http:\/\/id.crossref.org\/issn\/0167-8655","issn-type":"print"},{"issue":"25","key":"70_6256485","doi-asserted-by":"publisher","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","volume":"95","author":"Eisen","year":"1998","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"71_33557475","first-page":"S12","volume":"9","year":"2008","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"3","key":"72_30603835","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/nbt0308-303","volume":"26","author":"Ringner","year":"2008","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"9","key":"73_21660580","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/bioinformatics\/btl060","volume":"22","year":"2006","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"74_38301605","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1186\/1471-2105-11-503","volume":"11","author":"Freyhult","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"19","key":"75_29282250","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1093\/bioinformatics\/btm344","volume":"23","year":"2007","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"1","key":"76_17462311","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/jnci\/95.1.14","volume":"95","author":"Simon","year":"2003","journal-title":"JNCI Journal of the National Cancer Institute","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"issue":"6","key":"77_34744391","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.tibtech.2009.02.010","volume":"27","author":"Phan","year":"2009","journal-title":"Trends in biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/0167-7799","issn-type":"print"},{"issue":"4","key":"78_37789016","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/tpj.2010.57","volume":"10","author":"Luo","year":"2010","journal-title":"The pharmacogenomics journal","ISSN":"http:\/\/id.crossref.org\/issn\/1470-269X","issn-type":"print"},{"key":"79_43269586","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2288-9-85","volume":"9","year":"2009","journal-title":"BMC MED RES METHODOLOGY"},{"key":"80_38368577","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1186\/1471-2105-11-523","volume":"11","author":"Blagus","year":"2010","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"3","key":"81_36062021","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/bioinformatics\/btp648","volume":"26","year":"2010","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"4","key":"82_37789013","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/tpj.2010.34","volume":"10","author":"Fan","year":"2010","journal-title":"The pharmacogenomics journal","ISSN":"http:\/\/id.crossref.org\/issn\/1470-269X","issn-type":"print"},{"issue":"4","key":"83_37789017","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/tpj.2010.56","volume":"10","author":"Parry","year":"2010","journal-title":"The pharmacogenomics journal","ISSN":"http:\/\/id.crossref.org\/issn\/1470-269X","issn-type":"print"},{"issue":"8","key":"84_37791774","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1038\/nbt.1665","volume":"28","author":"Shi","year":"2010","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"2","key":"85_34864695","doi-asserted-by":"publisher","first-page":"69","DOI":"10.2174\/138920208784139546","volume":"9","author":"Dougherty","year":"2008","ISSN":"http:\/\/id.crossref.org\/issn\/1389-2029","issn-type":"print"},{"issue":"9","key":"86_22528535","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1056\/NEJMc061813","volume":"355","author":"Lin","year":"2006","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"2","key":"87_36026201","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/path.2648","volume":"220","author":"Weigelt","year":"2010","journal-title":"The Journal of pathology","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"issue":"9458","key":"88_18676252","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0140-6736(05)17866-0","volume":"365","author":"Michiels","year":"2005","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"10","key":"89_19672850","doi-asserted-by":"publisher","first-page":"6562","DOI":"10.1073\/pnas.102102699","volume":"99","year":"2002","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"90_21680889","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2105-7-91","volume":"7","author":"Varma","year":"2006","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"3","key":"91_18038316","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1093\/bioinformatics\/btg419","volume":"20","author":"Braga-Neto","year":"2004","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"9","key":"92_18827614","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1093\/bioinformatics\/bti294","volume":"21","year":"2005","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"key":"93_43269587","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.patrec.2008.06.018","volume":"29","year":"2008","journal-title":"PATTERN RECOGNITION LETT"},{"issue":"2","key":"94_36332056","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1158\/1078-0432.CCR-09-1815","volume":"16","year":"2010","journal-title":"Clinical Cancer Research","ISSN":"http:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"issue":"5643","key":"95_17852504","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1126\/science.1087447","volume":"302","year":"2003","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"96_27053783","first-page":"S7","volume":"7","year":"2006","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"2","key":"98_28347519","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bib\/bbm007","volume":"8","year":"2007","journal-title":"Briefings in Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"issue":"2","key":"99_18808621","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00006199-200503000-00009","volume":"54","author":"Lee","year":"2005","journal-title":"Nursing research","ISSN":"http:\/\/id.crossref.org\/issn\/0029-6562","issn-type":"print"},{"issue":"4","key":"100_18769351","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/ng1533","volume":"37","author":"Sebastiani","year":"2005","journal-title":"Nature genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"101_43269588","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1752-0509-5-121","volume":"5","year":"2011","journal-title":"BMC SYS BIOL"},{"key":"102_43269589","doi-asserted-by":"crossref","first-page":"U318","DOI":"10.1038\/nature08712","volume":"463","year":"2010","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"103_29899965","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1371\/journal.pbio.0050054","volume":"5","year":"2007","journal-title":"PLoS biology","ISSN":"http:\/\/id.crossref.org\/issn\/1544-9173","issn-type":"print"},{"issue":"7","key":"104_31312661","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/ng.167","volume":"40","author":"Zhu","year":"2008","journal-title":"Nature genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"14","key":"106_36848424","doi-asserted-by":"publisher","first-page":"6286","DOI":"10.1073\/pnas.0913357107","volume":"107","year":"2010","journal-title":"PNAS","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"107_39836122","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1742-4682-8-13","volume":"8","author":"Ooi","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1742-4682","issn-type":"print"},{"issue":"18","key":"108_18561289","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1093\/bioinformatics\/bth448","volume":"20","year":"2004","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"3","key":"109_7736734","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","volume":"22","author":"Kauffman","year":"1969","journal-title":"Journal of Theoretical Biology","ISSN":"http:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"issue":"2","key":"110_16916947","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/bioinformatics\/18.2.261","volume":"18","author":"Shmulevich","year":"2002","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"2","key":"114_16058977","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1006\/jtbi.1995.0199","volume":"176","author":"Mestl","year":"1995","journal-title":"Journal of Theoretical Biology","ISSN":"http:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"issue":"3","key":"115_11623830","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0022-5193(69)80027-5","volume":"25","author":"Savageau","year":"1969","journal-title":"Journal of Theoretical Biology","ISSN":"http:\/\/id.crossref.org\/issn\/1095-8541","issn-type":"print"},{"key":"116_42220968","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1021\/ed063p1044","volume":"63","year":"1986","journal-title":"Journal of Chemical Education","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9584","issn-type":"print"},{"key":"117_38081923","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/nbt1094-994","volume":"12","year":"1994","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"key":"118_28020499","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/bj2860313","volume":"286","year":"1992","journal-title":"The Biochemical journal","ISSN":"http:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"7024","key":"119_18644897","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/nature03232","volume":"433","author":"Alvarez-Vasquez","year":"2005","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"120_43269590","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1752-0509-5-26","volume":"5","year":"2011","journal-title":"BMC SYS BIOL"},{"issue":"6","key":"121_18316618","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cell.2004.09.008","volume":"118","author":"Stelling","year":"2004","journal-title":"Cell","ISSN":"http:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"123_12241154","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1146\/annurev.ph.34.030172.000305","volume":"34","author":"Guyton","year":"1972","journal-title":"Annual Review of Physiology","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4278","issn-type":"print"},{"key":"124_43269591","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1086\/590200","volume":"75","year":"2008","ISSN":"http:\/\/id.crossref.org\/issn\/0031-8248","issn-type":"print"},{"key":"125_43269592","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.resp.2009.04.019","volume":"168","year":"2009","journal-title":"RESP PHYSIOL NEUROBIOL"},{"issue":"6","key":"126_33583551","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00422-008-0262-9","volume":"100","author":"French","year":"2009","journal-title":"Biological cybernetics","ISSN":"http:\/\/id.crossref.org\/issn\/0340-1200","issn-type":"print"},{"issue":"3","key":"127_37318386","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3390\/ijms11030982","volume":"11","author":"Guzun","year":"2010","ISSN":"http:\/\/id.crossref.org\/issn\/1422-0067","issn-type":"print"},{"issue":"6715","key":"128_10714620","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/16483","volume":"397","author":"Alon","year":"1999","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"6636","key":"129_16826991","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/43199","volume":"387","author":"Barkai","year":"1997","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"130_43269593","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/msb.2010.37","volume":"6","year":"2010","journal-title":"MOL SYS BIOL"},{"issue":"7","key":"131_37428476","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nrg2795","volume":"11","author":"Hawkins","year":"2010","journal-title":"Nature reviews. Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"key":"132_40646708","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4137\/CIN.S6837","volume":"10","author":"Hicks","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1176-9351","issn-type":"print"},{"issue":"1","key":"133_33386793","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nrg2488","volume":"10","author":"Liu","year":"2009","journal-title":"Nature reviews. Genetics","ISSN":"http:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"7","key":"134_39274313","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1158\/0008-5472.CAN-10-2958","volume":"71","year":"2011","journal-title":"Cancer Research","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"issue":"2","key":"135_39369077","doi-asserted-by":"publisher","first-page":"e17490","DOI":"10.1371\/journal.pone.0017490","volume":"6","author":"Sun","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"issue":"7329","key":"136_38782705","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature09609","volume":"469","author":"Wang","year":"2011","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"7353","key":"137_40259315","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Bell","year":"2011","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"6","key":"138_37609665","doi-asserted-by":"publisher","first-page":"582","DOI":"10.4161\/cbt.10.6.12537","volume":"10","author":"Carter","year":"2010","journal-title":"Cancer biology & therapy","ISSN":"http:\/\/id.crossref.org\/issn\/1538-4047","issn-type":"print"},{"issue":"7216","key":"139_31861701","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature07385","volume":"455","author":"McLendon","year":"2008","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"140_43269594","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1089\/cmb.2010.0265","volume":"18","year":"2011","journal-title":"J COMP BIO"},{"issue":"12","key":"141_37396026","doi-asserted-by":"publisher","first-page":"i237","DOI":"10.1093\/bioinformatics\/btq182","volume":"26","year":"2010","journal-title":"Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1367-4803","issn-type":"print"},{"issue":"2","key":"142_15817415","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0006-3495(95)80232-8","volume":"68","author":"Hauri","year":"1995","journal-title":"Biophysical Journal","ISSN":"http:\/\/id.crossref.org\/issn\/0006-3495","issn-type":"print"},{"key":"143_32788595","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1121\/1.1908556","volume":"33","year":"1961","journal-title":"Journal of the Acoustical Society of America","ISSN":"http:\/\/id.crossref.org\/issn\/1520-8524","issn-type":"print"},{"issue":"4","key":"144_17590793","doi-asserted-by":"publisher","first-page":"R28","DOI":"10.1186\/gb-2003-4-4-r28","volume":"4","author":"Zeeberg","year":"2003","journal-title":"Genome biology","ISSN":"http:\/\/id.crossref.org\/issn\/1465-6906","issn-type":"print"},{"issue":"8","key":"145_35376529","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nbt.1557","volume":"27","author":"Dueber","year":"2009","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"47","key":"146_35961533","doi-asserted-by":"publisher","first-page":"17303","DOI":"10.1021\/ja906987s","volume":"131","author":"Zhang","year":"2009","journal-title":"Journal of the American Chemical Society","ISSN":"http:\/\/id.crossref.org\/issn\/1520-5126","issn-type":"print"},{"key":"147_43279783","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-60761-842-3_17","volume":"Vol. 673","year":"2010","journal-title":"COMPUTATIONAL BIOLOGY"},{"key":"148_43269596","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.automatica.2011.01.073","volume":"47","year":"2011","journal-title":"AUTOMATICA"},{"issue":"10","key":"149_35707676","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/nbt.1568","volume":"27","author":"Salis","year":"2009","journal-title":"Nature biotechnology","ISSN":"http:\/\/id.crossref.org\/issn\/1087-0156","issn-type":"print"},{"issue":"8","key":"150_36752367","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1093\/nar\/gkq091","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"7","key":"151_35215247","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.cell.2009.04.048","volume":"137","author":"Tabor","year":"2009","journal-title":"Cell","ISSN":"http:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"8","key":"152_36713181","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1093\/nar\/gkq121","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"7329","key":"153_38868498","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/nature09565","volume":"469","author":"Tamsir","year":"2011","journal-title":"Nature; Physical Science (London)","ISSN":"http:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"issue":"5987","key":"154_37316633","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1126\/science.1190719","volume":"329","year":"2010","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"4","key":"155_36677245","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/bib\/bbq002","volume":"11","year":"2010","journal-title":"Briefings in Bioinformatics","ISSN":"http:\/\/id.crossref.org\/issn\/1467-5463","issn-type":"print"},{"issue":"4","key":"156_39902012","doi-asserted-by":"publisher","first-page":"e18882","DOI":"10.1371\/journal.pone.0018882","volume":"6","author":"Bilitchenko","year":"2011","ISSN":"http:\/\/id.crossref.org\/issn\/1932-6203","issn-type":"print"},{"key":"158_38108684","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev.micro.091208.073229","volume":"64","author":"Silva-Rocha","year":"2010","journal-title":"Annual review of microbiology","ISSN":"http:\/\/id.crossref.org\/issn\/0066-4227","issn-type":"print"},{"issue":"3-4","key":"159_10573747","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1089\/106652700750050961","volume":"7","author":"Friedman","year":"2000","journal-title":"Journal of computational biology : a journal of computational molecular cell biology","ISSN":"http:\/\/id.crossref.org\/issn\/1066-5277","issn-type":"print"},{"key":"161_38581278","first-page":"S7","volume":"10","year":"2009","journal-title":"BMC bioinformatics [electronic resource]","ISSN":"http:\/\/id.crossref.org\/issn\/1471-2105","issn-type":"print"},{"issue":"2","key":"162_17058127","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1089\/10665270252935520","volume":"9","author":"Pachter","year":"2002","journal-title":"Journal of computational biology : a journal of computational molecular cell biology","ISSN":"http:\/\/id.crossref.org\/issn\/1066-5277","issn-type":"print"},{"key":"163_42220968","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1021\/ed063p1044","volume":"63","year":"1986","journal-title":"Journal of Chemical Education","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9584","issn-type":"print"},{"key":"164_24886751","first-page":"994","volume":"12","year":"1994","journal-title":"Biotechnology (Reading, Mass.)","ISSN":"http:\/\/id.crossref.org\/issn\/0740-7378","issn-type":"print"},{"issue":"8","key":"165_36582214","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1093\/nar\/gkq075","volume":"38","year":"2010","journal-title":"Nucleic Acids Research","ISSN":"http:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/13\/4\/430\/443353\/bbs026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T22:39:33Z","timestamp":1642891173000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article-lookup\/doi\/10.1093\/bib\/bbs026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":153,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,7,25]]},"published-print":{"date-parts":[[2012,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bbs026","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,1]]}}}