{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:55:58Z","timestamp":1787896558089,"version":"build-2784847793"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brief Bioinform"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1093\/bib\/bbv060","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:19:59Z","timestamp":1438906799000},"page":"494-504","source":"Crossref","is-referenced-by-count":121,"title":["Problems, challenges and promises: perspectives on precision medicine"],"prefix":"10.1093","volume":"17","author":[{"given":"David J.","family":"Duffy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"2016051723473484000_17.3.494.1","doi-asserted-by":"publisher","DOI":"10.1007\/s40484-013-0009-z"},{"key":"2016051723473484000_17.3.494.2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct163"},{"key":"2016051723473484000_17.3.494.3","doi-asserted-by":"publisher","DOI":"10.1186\/gm514"},{"key":"2016051723473484000_17.3.494.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.227"},{"key":"2016051723473484000_17.3.494.5","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201100306"},{"key":"2016051723473484000_17.3.494.6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fgene.2014.00152","article-title":"Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial","volume":"5","author":"Servant","year":"2014","journal-title":"Front Genet"},{"key":"2016051723473484000_17.3.494.7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.arbres.2010.09.009","article-title":"P4 Medicine: the future around the corner","volume":"47","author":"Sobradillo","year":"2011","journal-title":"Arch Bronconeumol"},{"key":"2016051723473484000_17.3.494.8","unstructured":"The CASyM Consortium. The CASyM roadmap: Implementation of Systems Medicine across Europe, version 1.0. 2014, CASyM administrative Office on behalf of the CASyM consortium, J\u00fclich, Germany."},{"key":"2016051723473484000_17.3.494.9","doi-asserted-by":"publisher","DOI":"10.2217\/pme.13.57"},{"key":"2016051723473484000_17.3.494.10","doi-asserted-by":"publisher","DOI":"10.1186\/gm538"},{"key":"2016051723473484000_17.3.494.11","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2013-002428"},{"key":"2016051723473484000_17.3.494.12","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140314130449"},{"key":"2016051723473484000_17.3.494.13","unstructured":"Ranck J . Connected Health: How Mobile Phones, Cloud and Big Data Will Reinvent Healthcare. San Francisco, CA: GigaOM Books, 2012."},{"key":"2016051723473484000_17.3.494.14","unstructured":"Bogan D Spence J Donnelly P . Connected Health in Ireland: An All Island Review. 2010, Enterprise Ireland Dublin, Ireland."},{"key":"2016051723473484000_17.3.494.15","unstructured":"Health DO Executive HS First PS . eHealth Stragety for Ireland. http:\/\/health.gov.ie\/blog\/publications\/ehealth-strategy-for-ireland\/ ."},{"key":"2016051723473484000_17.3.494.16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.7215"},{"key":"2016051723473484000_17.3.494.17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2332"},{"key":"2016051723473484000_17.3.494.18","unstructured":"Committee on A Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease. Washington, DC: National Research Council of the National Academies, 2011."},{"key":"2016051723473484000_17.3.494.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1503104"},{"key":"2016051723473484000_17.3.494.20","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0391"},{"key":"2016051723473484000_17.3.494.21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.6785"},{"key":"2016051723473484000_17.3.494.22","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a014415"},{"key":"2016051723473484000_17.3.494.23","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672315000099"},{"key":"2016051723473484000_17.3.494.24","doi-asserted-by":"publisher","DOI":"10.1126\/science.7545954"},{"key":"2016051723473484000_17.3.494.25","doi-asserted-by":"publisher","DOI":"10.1038\/378789a0"},{"key":"2016051723473484000_17.3.494.26","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70188-2"},{"key":"2016051723473484000_17.3.494.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2011.00388.x"},{"key":"2016051723473484000_17.3.494.28","doi-asserted-by":"publisher","DOI":"10.2217\/pme.13.8"},{"key":"2016051723473484000_17.3.494.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2015.04.001"},{"key":"2016051723473484000_17.3.494.30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2015\/731479","article-title":"Challenges in using circulating miRNAs as cancer biomarkers","volume":"2015","author":"Tiberio","year":"2015","journal-title":"Biomed Res Int"},{"key":"2016051723473484000_17.3.494.31","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.94"},{"key":"2016051723473484000_17.3.494.32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt703"},{"key":"2016051723473484000_17.3.494.33","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2529"},{"key":"2016051723473484000_17.3.494.34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fphys.2014.00021","article-title":"Why model?","volume":"5","author":"Wolkenhauer","year":"2014","journal-title":"Front Physiol"},{"key":"2016051723473484000_17.3.494.35","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0082-6"},{"key":"2016051723473484000_17.3.494.36","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.113483hm"},{"key":"2016051723473484000_17.3.494.37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3238"},{"key":"2016051723473484000_17.3.494.38","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2901"},{"key":"2016051723473484000_17.3.494.39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/wsbm.1253","article-title":"Systems biology-embedded target validation: improving efficacy in drug discovery","volume":"6","author":"Vandamme","year":"2014","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"2016051723473484000_17.3.494.40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1098\/rsfs.2010.0011","article-title":"What it takes to understand and cure a living system: computational systems biology and a systems biology-driven pharmacokinetics\u2013pharmacodynamics platform","volume":"1","author":"Swat","year":"2010","journal-title":"Interface Focus"},{"key":"2016051723473484000_17.3.494.41","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj092"},{"key":"2016051723473484000_17.3.494.42","doi-asserted-by":"crossref","first-page":"D542","DOI":"10.1093\/nar\/gku1181","article-title":"BioModels: ten-year anniversary","volume":"D1","author":"Chelliah","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2016051723473484000_17.3.494.43","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbp056"},{"key":"2016051723473484000_17.3.494.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.013"},{"key":"2016051723473484000_17.3.494.45","doi-asserted-by":"publisher","DOI":"10.1038\/nature06516"},{"key":"2016051723473484000_17.3.494.46","unstructured":"Division UNDoEaSAP. World Population Ageing: 1950\u20132050 . New York: United Nations, 2002."},{"key":"2016051723473484000_17.3.494.47","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140314115505"},{"key":"2016051723473484000_17.3.494.48","doi-asserted-by":"publisher","DOI":"10.1038\/nature12625"},{"key":"2016051723473484000_17.3.494.49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/msb4100088","article-title":"Depicting combinatorial complexity with the molecular interaction map notation","volume":"2","author":"Kohn","year":"2006","journal-title":"Mol Syst Biol"},{"key":"2016051723473484000_17.3.494.50","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr336"},{"key":"2016051723473484000_17.3.494.51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004085"},{"key":"2016051723473484000_17.3.494.52","unstructured":"Dubitzky W Krebs O Eils R . Minding, OLAPing, and mining biological data: towards a data warehousing concept in biology, NETTAB - Network Tools and Applications in Biology. In: NETTAB\u2014Network Tools and Applications in Biology, Genova, Italy. 2001."},{"key":"2016051723473484000_17.3.494.53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fgene.2014.00273","article-title":"Advances in translational biomedicine from systems approaches","volume":"5","author":"Capobianco","year":"2014","journal-title":"Front Genet"},{"key":"2016051723473484000_17.3.494.54","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.4"},{"key":"2016051723473484000_17.3.494.55","doi-asserted-by":"publisher","DOI":"10.2174\/1381612820666140314145445"},{"key":"2016051723473484000_17.3.494.56","first-page":"29","article-title":"Can personalized medicine survive?","volume":"17","author":"Gibson","year":"1971","journal-title":"Can Fam Phys"},{"key":"2016051723473484000_17.3.494.57","unstructured":"United Health Center for Health Reform and Modernization. Personalized Medicine: Trends and Prospects for the New Science of Genetic Testing and Molecular Diagnostics. http:\/\/www.unitedhealthgroup.com\/\u223c\/media\/UHG\/PDF\/2012\/UNH-Working-Paper-7.ashx, 2012."},{"key":"2016051723473484000_17.3.494.58","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1145\/1029496.1029527","article-title":"Beyond power: making bioinformatics tools user-centered","volume":"47","author":"Javahery","year":"2004","journal-title":"Commun ACM"},{"key":"2016051723473484000_17.3.494.59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1206"},{"key":"2016051723473484000_17.3.494.60","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318238216e"},{"key":"2016051723473484000_17.3.494.61","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.4799"},{"key":"2016051723473484000_17.3.494.62","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.3043"},{"key":"2016051723473484000_17.3.494.63","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.3605"},{"key":"2016051723473484000_17.3.494.64","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.54"},{"key":"2016051723473484000_17.3.494.65","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-s1-p38"},{"key":"2016051723473484000_17.3.494.66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1500523"},{"key":"2016051723473484000_17.3.494.67","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.211"},{"key":"2016051723473484000_17.3.494.68","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.3639"},{"key":"2016051723473484000_17.3.494.69","doi-asserted-by":"publisher","DOI":"10.1038\/nature12627"},{"key":"2016051723473484000_17.3.494.70","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.581"},{"key":"2016051723473484000_17.3.494.71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-275347"},{"key":"2016051723473484000_17.3.494.72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-443218"},{"key":"2016051723473484000_17.3.494.73","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12550"},{"key":"2016051723473484000_17.3.494.74","unstructured":"Timmerman L . What\u2019s in a Name? A Lot, When It Comes to \u2018Precision Medicine\u2019. Xconomy. http:\/\/www.xconomy.com\/national\/2013\/02\/04\/whats-in-a-name-a-lot-when-it-comes-to-precision-medicine\/: Xconomy, 2013."},{"key":"2016051723473484000_17.3.494.75","doi-asserted-by":"crossref","unstructured":"Dickenson D . Me Medicine vs. We Medicine: Reclaiming Biotechnology for the Common Good. New York: Columbia University Press, 2013.","DOI":"10.7312\/dick15974"},{"key":"2016051723473484000_17.3.494.76","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3106"},{"key":"2016051723473484000_17.3.494.77","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h867"},{"key":"2016051723473484000_17.3.494.78","doi-asserted-by":"publisher","DOI":"10.2217\/pme.12.37"},{"key":"2016051723473484000_17.3.494.79","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1501194"},{"key":"2016051723473484000_17.3.494.80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-6171.2012.00334.x"},{"key":"2016051723473484000_17.3.494.81","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2014.10.019"},{"key":"2016051723473484000_17.3.494.82","doi-asserted-by":"publisher","DOI":"10.1038\/506146a"},{"key":"2016051723473484000_17.3.494.83","unstructured":"Gray P . Free to Learn: Why Unleashing the Instinct to Play Will Make Our Children Happier, More Self-Reliant, and Better Students for Life. New York: Basic Books, 2013."}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/17\/3\/494\/6687486\/bbv060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T23:52:08Z","timestamp":1503532328000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article-lookup\/doi\/10.1093\/bib\/bbv060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":83,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,5,17]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1093\/bib\/bbv060"],"URL":"https:\/\/doi.org\/10.1093\/bib\/bbv060","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}