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High burden and pervasive positive selection of somatic mutations in normal human skin","volume":"348","year":"2015","journal-title":"Science"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B74","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","year":"2014","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B75","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1126\/science.aai8690","article-title":"DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification","volume":"355","year":"2017","journal-title":"Science"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B76","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jama.1971.03190200047010","article-title":"From the gene to behavior","volume":"218","year":"1971","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00278187","article-title":"The CpG dinucleotide and human genetic disease","volume":"78","year":"1988","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B78","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/274775a0","article-title":"Molecular basis of base substitution hotspots in Escherichia coli","volume":"274","year":"1978","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B79","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/onc.2016.192","article-title":"Base changes in tumour DNA have the power to reveal the causes and evolution of cancer","volume":"36","year":"2017","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B80","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/em.2850150208","article-title":"Mutational specificity of alkylating agents and the influence of DNA repair","volume":"15","year":"1990","journal-title":"Environ Mol Mutagen"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B81","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1086\/301965","article-title":"Neighboring-nucleotide effects on the rates of germ-line single-base-pair substitution in human genes","volume":"63","year":"1998","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B82","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/humu.1380050107","article-title":"Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and by selection","volume":"5","year":"1995","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B83","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/bib\/4.3.210","article-title":"Computational analysis of mutation spectra","volume":"4","year":"2003","journal-title":"Brief Bioinform"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B84","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1383-5742(03)00032-2","article-title":"Theoretical analysis of mutation hotspots and their DNA sequence context specificity","volume":"544","year":"2003","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B85","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0959-437X(00)00242-2","article-title":"Statistical inference of sequence-dependent mutation rates","volume":"11","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B86","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/jmbi.2001.4937","article-title":"Error rate and specificity of human and murine DNA polymerase eta","volume":"312","year":"2001","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B87","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/humu.10312","article-title":"Context of deletions and insertions in human coding sequences","volume":"23","year":"2004","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B88","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature01760","article-title":"Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation","volume":"424","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B89","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1016\/S0021-9258(18)67598-2","article-title":"O6-methylguanine mutation and repair is nonuniform. Selection for DNA most interactive with O6-methylguanine","volume":"261","year":"1986","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B90","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/nar\/20.5.1093","article-title":"Critical comparison of consensus methods for molecular sequences","volume":"20","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B91","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0022-5193(05)80692-7","article-title":"Threshold consensus methods for molecular sequences","volume":"159","year":"1992","journal-title":"J Theor Biol"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B92","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00439-002-0740-4","article-title":"Analysis of phylogenetically reconstructed mutational spectra in human mitochondrial DNA control region","volume":"111","year":"2002","journal-title":"Hum 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Application of the Fourier and wavelet models to Drosophila and mammalian proteins","volume":"154","year":"2000","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B109","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/genetics\/153.1.485","article-title":"Locating regions of differential variability in DNA and protein sequences","volume":"153","year":"1999","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B110","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.cell.2012.04.024","article-title":"Mutational processes molding the genomes of 21 breast cancers","volume":"149","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B111","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.celrep.2014.04.053","article-title":"Break-induced replication is a source of mutation clusters underlying kataegis","volume":"7","year":"2014","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B112","doi-asserted-by":"crossref","first-page":"14162","DOI":"10.1073\/pnas.0405974101","article-title":"Breakpoints of gross deletions coincide with non-B DNA conformations","volume":"101","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B113","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1093\/nar\/gkw261","article-title":"Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences","volume":"44","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B114","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/35106108","article-title":"Chromosome translocations: dangerous liaisons revisited","volume":"1","year":"2001","journal-title":"Nat Rev 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Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B118","doi-asserted-by":"crossref","first-page":"5508","DOI":"10.1158\/1078-0432.CCR-04-0085","article-title":"Conservation of breast cancer molecular subtypes and transcriptional patterns of tumor progression across distinct ethnic populations","volume":"10","year":"2004","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B119","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1158\/1078-0432.CCR-04-2421","article-title":"Breast cancer molecular subtypes respond differently to preoperative chemotherapy","volume":"11","year":"2005","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B120","doi-asserted-by":"crossref","first-page":"96.","DOI":"10.1186\/1471-2164-7-96","article-title":"The molecular portraits of breast tumors are conserved across microarray platforms","volume":"7","year":"2006","journal-title":"BMC 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Inst"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B124","doi-asserted-by":"crossref","first-page":"54.","DOI":"10.1186\/s12920-015-0129-6","article-title":"Development and verification of the PAM50-based Prosigna breast cancer gene signature assay","volume":"8","year":"2015","journal-title":"BMC Med Genomics"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B125","doi-asserted-by":"crossref","first-page":"43294.","DOI":"10.1038\/srep43294","article-title":"Personalized chemotherapy selection for breast cancer using gene expression profiles","volume":"7","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B126","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/humu.21557","article-title":"On the sequence-directed nature of human gene mutation: the role of genomic architecture and the local DNA sequence environment in mediating gene mutations underlying human inherited disease","volume":"32","year":"2011","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B127","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","year":"2002","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B128","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.96.15.8681","article-title":"CpG island methylator phenotype in colorectal cancer","volume":"96","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B129","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1101\/gr.117523.110","article-title":"Genome-scale analysis of aberrant DNA methylation in colorectal cancer","volume":"22","year":"2012","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B130","doi-asserted-by":"crossref","first-page":"66.","DOI":"10.1186\/s13073-014-0066-6","article-title":"Pan-cancer patterns of DNA 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USA"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B137","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/bib\/bbu039","article-title":"Deciphering oncogenic drivers: from single genes to integrated pathways","volume":"16","year":"2015","journal-title":"Brief Bioinform"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B138","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.sbi.2015.01.004","article-title":"\u2032Latent drivers\u2032 expand the cancer mutational landscape","volume":"32","year":"2015","journal-title":"Curr Opin Struct Biol"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B139","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B140","doi-asserted-by":"crossref","first-page":"54.","DOI":"10.1186\/1476-4598-10-54","article-title":"The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors","volume":"10","year":"2011","journal-title":"Mol Cancer"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B141","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/humu.22493","article-title":"Activating mutations cluster in the \u201cmolecular brake\u201d regions of protein kinases and do not associate with conserved or catalytic residues","volume":"35","year":"2014","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B142","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1093\/bioinformatics\/btt395","article-title":"OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes","volume":"29","year":"2013","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B143","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/humu.22963","article-title":"Mutation3D: cancer gene prediction through atomic clustering of coding variants in the structural proteome","volume":"37","year":"2016","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B144","doi-asserted-by":"crossref","first-page":"e66273.","DOI":"10.1371\/journal.pone.0066273","article-title":"Cancer missense mutations alter binding properties of proteins and their interaction networks","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B145","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/bioinformatics\/btv142","article-title":"Structure-PPi: a module for the annotation of cancer-related single-nucleotide variants at protein-protein interfaces","volume":"31","year":"2015","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170606090846_bbx049-B146","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/humu.22145","article-title":"Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine 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