{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T23:19:41Z","timestamp":1770679181404,"version":"3.49.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01LM012806"],"award-info":[{"award-number":["R01LM012806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01LM011177"],"award-info":[{"award-number":["R01LM011177"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01A174586"],"award-info":[{"award-number":["R01A174586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24A209851"],"award-info":[{"award-number":["U24A209851"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA196508"],"award-info":[{"award-number":["R21CA196508"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Testicular germ cell tumors (TGCTs) are classified into two main subtypes, seminoma (SE) and non-seminoma (NSE), but their molecular distinctions remain largely unexplored. Here, we used expression data for mRNAs and microRNAs (miRNAs) from The Cancer Genome Atlas (TCGA) to perform a systematic investigation to explain the different telomere length (TL) features between NSE (n\u2009=\u200948) and SE (n\u2009=\u200955). We found that TL elongation was dominant in NSE, whereas TL shortening prevailed in SE. We further showed that both mRNA and miRNA expression profiles could clearly distinguish these two subtypes. Notably, four telomere-related genes (TelGenes) showed significantly higher expression and positively correlated with telomere elongation in NSE than SE: three telomerase activity-related genes (TERT, WRAP53 and MYC) and an independent telomerase activity gene (ZSCAN4). We also found that the expression of genes encoding Yamanaka factors was positively correlated with telomere lengthening in NSE. Among them, SOX2 and MYC were highly expressed in NSE versus SE, while POU5F1 and KLF4 had the opposite patterns. These results suggested that enhanced expression of both TelGenes (TERT, WRAP53, MYC and ZSCAN4) and Yamanaka factors might induce telomere elongation in NSE. Conversely, the relative lack of telomerase activation and low expression of independent telomerase activity pathway during cell division may be contributed to telomere shortening in SE. Taken together, our results revealed the potential molecular profiles and regulatory roles involving the TL difference between NSE and SE, and provided a better molecular understanding of this complex disease.<\/jats:p>","DOI":"10.1093\/bib\/bby020","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T12:28:48Z","timestamp":1519907328000},"page":"1502-1512","source":"Crossref","is-referenced-by-count":18,"title":["Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2169-0808","authenticated-orcid":false,"given":"Hua","family":"Sun","sequence":"first","affiliation":[{"name":"Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}]},{"given":"Pora","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}]},{"given":"Peilin","family":"Jia","sequence":"additional","affiliation":[{"name":"Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"}]},{"given":"Ae Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"},{"name":"College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, 57922, Republic of Korea"}]},{"given":"Han","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"},{"name":"Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-0914","authenticated-orcid":false,"given":"Zhongming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"},{"name":"Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA"},{"name":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37203, USA"}]}],"member":"286","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"issue":"4","key":"2019100807490622500_bby020-B1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/aje\/kwt267","article-title":"A hierarchical frailty model for familial testicular germ-cell tumors","volume":"179","author":"Valberg","year":"2014","journal-title":"Am J Epidemiol"},{"issue":"9512","key":"2019100807490622500_bby020-B2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0140-6736(06)68305-0","article-title":"Testicular germ-cell cancer","volume":"367","author":"Horwich","year":"2006","journal-title":"Lancet"},{"issue":"8","key":"2019100807490622500_bby020-B3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(02)00820-3","article-title":"Stem-cell origin of metastasis and heterogeneity in solid tumours","volume":"3","author":"Tu","year":"2002","journal-title":"Lancet Oncol"},{"issue":"1","key":"2019100807490622500_bby020-B4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1746-1596-8-57","article-title":"Oncological outcomes in patients with stage I testicular seminoma and nonseminoma: pathological risk factors for relapse and feasibility of surveillance after orchiectomy","volume":"8","author":"Kobayashi","year":"2013","journal-title":"Diagn Pathol"},{"issue":"35","key":"2019100807490622500_bby020-B5","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1200\/JCO.2006.08.4285","article-title":"Biology and genetics of adult male germ cell tumors","volume":"24","author":"Houldsworth","year":"2006","journal-title":"J Clin Oncol"},{"issue":"8","key":"2019100807490622500_bby020-B6","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1200\/JCO.2008.16.4202","article-title":"Cisplatin and etoposide in childhood germ cell tumor: brazilian pediatric oncology society protocol GCT-91","volume":"27","author":"Lopes","year":"2009","journal-title":"J Clin Oncol"},{"issue":"6","key":"2019100807490622500_bby020-B7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1200\/JCO.2014.59.1420","article-title":"Lowered cisplatin dose and no bleomycin in the treatment of pediatric germ cell tumors: results of the GCT-99 protocol from the Brazilian germ cell pediatric oncology cooperative group","volume":"34","author":"Lopes","year":"2016","journal-title":"J Clin Oncol"},{"key":"2019100807490622500_bby020-B8","doi-asserted-by":"crossref","first-page":"4906","DOI":"10.1200\/JCO.2009.26.8128","article-title":"Prognostic factors in patients with metastatic germ cell tumors who experienced treatment failure with cisplatin-based first-line chemotherapy","volume":"28","author":"International Prognostic Factors Study Group","year":"2010","journal-title":"J Clin Oncol"},{"key":"2019100807490622500_bby020-B9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.bi.53.070184.001115","article-title":"The molecular structure of centromeres and telomeres","volume":"53","author":"Blackburn","year":"1984","journal-title":"Annu Rev Biochem"},{"key":"2019100807490622500_bby020-B10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrm2848","article-title":"Telomeres: protecting chromosomes against genome instability","volume":"11","author":"O'Sullivan","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"2019100807490622500_bby020-B11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.semcancer.2011.10.001","article-title":"Role of telomeres and telomerase in cancer","volume":"21","author":"Shay","year":"2011","journal-title":"Semin Cancer Biol"},{"issue":"5193","key":"2019100807490622500_bby020-B12","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"issue":"5","key":"2019100807490622500_bby020-B13","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","article-title":"A survey of telomerase activity in human cancer","volume":"33","author":"Shay","year":"1997","journal-title":"Eur J Cancer"},{"issue":"4","key":"2019100807490622500_bby020-B14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/ng1297-498","article-title":"Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT","volume":"17","author":"Weinrich","year":"1997","journal-title":"Nat Genet"},{"issue":"4","key":"2019100807490622500_bby020-B15","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.ajpath.2011.06.018","article-title":"Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes","volume":"179","author":"Heaphy","year":"2011","journal-title":"Am J Pathol"},{"issue":"3","key":"2019100807490622500_bby020-B16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/ng.3781","article-title":"Systematic analysis of telomere length and somatic alterations in 31 cancer types","volume":"49","author":"Barthel","year":"2017","journal-title":"Nat Genet"},{"issue":"9","key":"2019100807490622500_bby020-B17","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1093\/nar\/gku181","article-title":"Estimating telomere length from whole genome sequence data","volume":"42","author":"Ding","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"2019100807490622500_bby020-B18","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019100807490622500_bby020-B19","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gkm700","article-title":"The telomerase database","volume":"36","author":"Podlevsky","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"2019100807490622500_bby020-B20","doi-asserted-by":"crossref","first-page":"10717.","DOI":"10.1038\/ncomms10717","article-title":"Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders","volume":"7","author":"Werling","year":"2016","journal-title":"Nat Commun"},{"issue":"1","key":"2019100807490622500_bby020-B21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13059-014-0568-y","article-title":"Comprehensive miRNA sequence analysis reveals survival differences in diffuse large B-cell lymphoma patients","volume":"16","author":"Lim","year":"2015","journal-title":"Genome Biol"},{"key":"2019100807490622500_bby020-B22","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"2019100807490622500_bby020-B23","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1158\/0008-5472.CAN-16-2460","article-title":"Tissue-specific signaling networks rewired by major somatic mutations in human cancer revealed by proteome-wide discovery","volume":"77","author":"Zhao","year":"2017","journal-title":"Cancer Res"},{"issue":"1","key":"2019100807490622500_bby020-B24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/nar\/24.1.238","article-title":"TRANSFAC: a database on transcription factors and their DNA binding sites","volume":"24","author":"Wingender","year":"1996","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2019100807490622500_bby020-B25","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1038\/srep11432","article-title":"TRRUST: a reference database of human transcriptional regulatory interactions","volume":"5","author":"Han","year":"2015","journal-title":"Sci Rep"},{"key":"2019100807490622500_bby020-B26","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"eLife"},{"issue":"D1","key":"2019100807490622500_bby020-B27","doi-asserted-by":"crossref","first-page":"D68","DOI":"10.1093\/nar\/gkt1181","article-title":"miRBase: annotating high confidence microRNAs using deep sequencing data","volume":"42","author":"Kozomara","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"2019100807490622500_bby020-B28","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.18632\/oncotarget.2954","article-title":"Clinically relevant genes and regulatory pathways associated with NRASQ61 mutations in melanoma through an integrative genomics approach","volume":"6","author":"Jiang","year":"2015","journal-title":"Oncotarget"},{"issue":"11","key":"2019100807490622500_bby020-B29","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"2019100807490622500_bby020-B30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.humpath.2016.03.015","article-title":"High-resolution telomere fluorescence in situ hybridization reveals intriguing anomalies in germ cell tumors","volume":"54","author":"Shekhani","year":"2016","journal-title":"Hum Pathol"},{"issue":"6088","key":"2019100807490622500_bby020-B31","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1126\/science.1218370","article-title":"Wnt\/beta-catenin signaling regulates telomerase in stem cells and cancer cells","volume":"336","author":"Hoffmeyer","year":"2012","journal-title":"Science"},{"issue":"3","key":"2019100807490622500_bby020-B32","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.critrevonc.2013.10.001","article-title":"Molecular biology of testicular germ cell tumors: unique features awaiting clinical application","volume":"89","author":"Boublikova","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"issue":"7290","key":"2019100807490622500_bby020-B33","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nature08882","article-title":"Zscan4 regulates telomere elongation and genomic stability in ES cells","volume":"464","author":"Zalzman","year":"2010","journal-title":"Nature"},{"issue":"4","key":"2019100807490622500_bby020-B34","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.bbrc.2015.09.107","article-title":"ZSCAN4 and TRF1: a functionally indirect interaction in cancer cells independent of telomerase activity","volume":"466","author":"Lee","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"2019100807490622500_bby020-B35","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1067003","article-title":"Genomic targets of the human c-Myc protein","volume":"17","author":"Fernandez","year":"2003","journal-title":"Genes Dev"},{"issue":"5914","key":"2019100807490622500_bby020-B36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1165357","article-title":"A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis","volume":"323","author":"Venteicher","year":"2009","journal-title":"Science"},{"issue":"1","key":"2019100807490622500_bby020-B37","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/cr.2012.157","article-title":"Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation","volume":"23","author":"Jiang","year":"2013","journal-title":"Cell Res"},{"issue":"5","key":"2019100807490622500_bby020-B38","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"15","key":"2019100807490622500_bby020-B39","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/jnci\/91.15.1321","article-title":"Telomerase activity in germ cell cancers and mature teratomas","volume":"91","author":"Albanell","year":"1999","journal-title":"J Natl Cancer Inst"},{"issue":"7","key":"2019100807490622500_bby020-B40","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/sj.bjc.6603671","article-title":"Telomere and telomerase in stem cells","volume":"96","author":"Hiyama","year":"2007","journal-title":"Br J Cancer"},{"issue":"1","key":"2019100807490622500_bby020-B41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3835(01)00501-8","article-title":"The correlation of TERT expression with c-myc expression in cervical cancer","volume":"168","author":"Sagawa","year":"2001","journal-title":"Cancer Lett"},{"issue":"38","key":"2019100807490622500_bby020-B42","doi-asserted-by":"crossref","first-page":"40775","DOI":"10.18632\/oncotarget.5805","article-title":"CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc","volume":"6","author":"Pu","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"2019100807490622500_bby020-B43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/abbs\/gmt124","article-title":"MiR-181c modulates the proliferation, migration, and invasion of neuroblastoma cells by targeting Smad7","volume":"46","author":"Li","year":"2014","journal-title":"Acta Biochim Biophys Sin"},{"issue":"2 Pt 1","key":"2019100807490622500_bby020-B44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"Greider","year":"1985","journal-title":"Cell"},{"issue":"1561","key":"2019100807490622500_bby020-B45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1098\/rstb.2010.0291","article-title":"Telomeres in cancer and ageing","volume":"366","author":"Donate","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"2019100807490622500_bby020-B46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cell.2010.01.004","article-title":"Chaperoning histones during DNA replication and repair","volume":"140","author":"Ransom","year":"2010","journal-title":"Cell"},{"key":"2019100807490622500_bby020-B47","first-page":"2696","article-title":"High telomerase activity is an independent prognostic indicator of poor outcome in colorectal cancer","volume":"6","author":"Tatsumoto","year":"2000","journal-title":"Clin Cancer Res"},{"key":"2019100807490622500_bby020-B48","first-page":"2883","article-title":"hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer","volume":"8","author":"Wang","year":"2002","journal-title":"Clin Cancer Res"},{"issue":"3","key":"2019100807490622500_bby020-B49","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.lungcan.2007.11.001","article-title":"Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer","volume":"60","author":"Frias","year":"2008","journal-title":"Lung Cancer"},{"issue":"4","key":"2019100807490622500_bby020-B50","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1053\/ejso.2002.1374","article-title":"hTERT mRNA expression correlates with telomerase activity in human breast cancer","volume":"29","author":"Kirkpatrick","year":"2003","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"2019100807490622500_bby020-B51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/labinvest.3700710","article-title":"High telomerase activity and long telomeres in advanced hepatocellular carcinomas with poor prognosis","volume":"88","author":"Oh","year":"2008","journal-title":"Lab Invest"},{"issue":"10","key":"2019100807490622500_bby020-B52","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/cncr.23419","article-title":"Telomere length and telomerase subunits as diagnostic and prognostic biomarkers in Barrett carcinoma","volume":"112","author":"Gertler","year":"2008","journal-title":"Cancer"},{"issue":"10","key":"2019100807490622500_bby020-B53","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1200\/JCO.2004.09.160","article-title":"Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma","volume":"22","author":"Gertler","year":"2004","journal-title":"J Clin Oncol"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/20\/4\/1502\/30119766\/bby020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/bib\/article-pdf\/20\/4\/1502\/30119766\/bby020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:46:12Z","timestamp":1603921572000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/article\/20\/4\/1502\/4944720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,3,20]]},"published-print":{"date-parts":[[2019,7,19]]}},"URL":"https:\/\/doi.org\/10.1093\/bib\/bby020","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2018,3,20]]}}}