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Computational mutation analysis can greatly narrow down the efforts on experimental work. To increase the utilization of current computational resources, we \ufb01rst provide an overview of computational prediction of amino acid variations that influence protein PTMs and their functional analysis. We also discuss the challenges that are faced while developing novel in silico approaches in the future. The development of better methods for mutation analysis-related protein PTMs will help to facilitate the development of personalized precision medicine.<\/jats:p>","DOI":"10.1093\/bib\/bby036","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T19:07:07Z","timestamp":1523732827000},"page":"1597-1606","source":"Crossref","is-referenced-by-count":6,"title":["Proteomic analysis and prediction of amino acid variations that influence protein posttranslational modifications"],"prefix":"10.1093","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0045-868X","authenticated-orcid":false,"given":"Shaoping","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Mathematics and Numerical Simulation and High-Performance Computing Laboratory, School of Sciences, Nanchang University, Nanchang, Jiangxi 330031, China"}]},{"given":"Lina","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Science, Nanchang Institute of Technology, Nanchang, Jiangxi 330031, China"}]},{"given":"Man","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Sciences, Nanchang University, Nanchang, Jiangxi 330031, China"}]},{"given":"Guodong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Sciences, Nanchang University, Nanchang, Jiangxi 330031, China"}]},{"given":"Jialin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Mathematics, School of Sciences, Nanchang University, Nanchang, Jiangxi 330031, China"}]}],"member":"286","published-online":{"date-parts":[[2018,5,17]]},"reference":[{"key":"2020080807562370300_bby036-B1","doi-asserted-by":"crossref","first-page":"e1004919.","DOI":"10.1371\/journal.pgen.1004919","article-title":"Evolutionary constraint and disease associations of post-translational modification sites in human genomes","volume":"11","author":"Reimand","year":"2015","journal-title":"PLoS Genet"},{"issue":"1","key":"2020080807562370300_bby036-B2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jprot.2011.09.014","article-title":"Proteomic databases and tools to decipher post-translational modifications","volume":"75","author":"Kamath","year":"2011","journal-title":"J Proteomics"},{"key":"2020080807562370300_bby036-B3","volume-title":"Genomics and Proteomics for Clinical Discovery and Development. 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