{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:25:08Z","timestamp":1762917908893,"version":"3.37.3"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Program on Key Basic Research Project","award":["2014CB910504","National Natural Science Foundation of China","81421063"],"award-info":[{"award-number":["2014CB910504","National Natural Science Foundation of China","81421063"]}]},{"name":"National High Technology Research and Development Program of China","award":["2014AA021102"],"award-info":[{"award-number":["2014AA021102"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61473106","31571331","61502126"],"award-info":[{"award-number":["61473106","31571331","61502126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016T90309","2015M571436","LBH-Z14134"],"award-info":[{"award-number":["2016T90309","2015M571436","LBH-Z14134"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["QC2015020"],"award-info":[{"award-number":["QC2015020"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Weihan Yu Youth Science Fund Project of Harbin Medical University"},{"name":"Heilongjiang Province Youth Science and technology","award":["UNPYSCT-2016189","UNPYSCT-2017060"],"award-info":[{"award-number":["UNPYSCT-2016189","UNPYSCT-2017060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long non-coding RNAs (lncRNAs) have been revealed to play essential roles in the human cardiovascular system. However, information about their mechanisms is limited, and a comprehensive view of cardiac lncRNAs is lacking from a multiple tissues perspective to date. Here, the landscape of the lncRNA transcriptome in human heart was summarized. We summarized all lncRNA transcripts from publicly available human transcriptome resources (156 heart samples and 210 samples from 29 other tissues) and systematically analysed all annotated and novel lncRNAs expressed in heart. A total of 7485 lncRNAs whose expression was elevated in heart (HE lncRNAs) and 453 lncRNAs expressed in all 30 analysed tissues (EIA lncRNAs) were extracted. Using various bioinformatics resources, methods and tools, the features of these lncRNAs were discussed from various perspectives, including genomic structure, conservation, dynamic variation during heart development, cis-regulation, differential expression in cardiovascular diseases and cancers as well as regulation at transcriptional and post-transcriptional levels. Afterwards, all the features discussed above were integrated into a user-friendly resource named CARDIO-LNCRNAS (http:\/\/bio-bigdata.hrbmu.edu.cn\/CARDIO-LNCRNAS\/ or http:\/\/www.bio-bigdata.net\/CARDIO-LNCRNAS\/). This study represents the first global view of lncRNAs in the human cardiovascular system based on multiple tissues and sheds light on the role of lncRNAs in developments and heart disorders.<\/jats:p>","DOI":"10.1093\/bib\/bby052","type":"journal-article","created":{"date-parts":[[2018,6,2]],"date-time":"2018-06-02T11:08:11Z","timestamp":1527937691000},"page":"1812-1825","source":"Crossref","is-referenced-by-count":20,"title":["Landscape of the long non-coding RNA transcriptome in human heart"],"prefix":"10.1093","volume":"20","author":[{"given":"Chunjie","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Na","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Junyi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Xiyun","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Lili","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Tao","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Caiqin","family":"Huo","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Yongsheng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"},{"name":"College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin, Heilongjiang, China"}]}],"member":"286","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"issue":"4","key":"2020080807563531300_bby052-B1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell"},{"issue":"9","key":"2020080807563531300_bby052-B2","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res"},{"issue":"18","key":"2020080807563531300_bby052-B3","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev"},{"issue":"3","key":"2020080807563531300_bby052-B4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long non-coding RNAs: insights into functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"6113","key":"2020080807563531300_bby052-B5","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.1231776","article-title":"Epigenetic regulation by long noncoding RNAs","volume":"338","author":"Lee","year":"2012","journal-title":"Science"},{"issue":"4","key":"2020080807563531300_bby052-B6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1101\/gr.165035.113","article-title":"Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals","volume":"24","author":"Washietl","year":"2014","journal-title":"Genome Res"},{"issue":"6220","key":"2020080807563531300_bby052-B7","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. 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