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Many circular RNAs (circRNAs) that originate from back-spliced exons have been identified in various cell lines across different species. However, the regulatory mechanism for transcription of circRNAs remains unclear. Therefore, there is an urgent need to construct a database detailing the transcriptional regulation of circRNAs. TRCirc (http:\/\/www.licpathway.net\/TRCirc) provides a resource for efficient retrieval, browsing and visualization of transcriptional regulation information of circRNAs. The current version of TRCirc documents 92\u00a0375 circRNAs and 161 transcription factors (TFs) from more than 100 cell types and together represent more than 765\u00a0000 TF\u2013circRNA regulatory relationships. Furthermore, TRCirc provides other regulatory information about transcription of circRNAs, including their expression, methylation levels, H3K27ac signals in regulation regions and super-enhancers associated with circRNAs. TRCirc provides a convenient, user-friendly interface to search, browse and visualize detailed information about these circRNAs.<\/jats:p>","DOI":"10.1093\/bib\/bby083","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T15:20:40Z","timestamp":1534519240000},"page":"2327-2333","source":"Crossref","is-referenced-by-count":59,"title":["TRCirc: a resource for transcriptional regulation information of circRNAs"],"prefix":"10.1093","volume":"20","author":[{"given":"Zhidong","family":"Tang","sequence":"first","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University"}]},{"given":"Xuecang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical University"}]},{"given":"Jianmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Medical Informatics, Daqing Campus, Harbin Medical 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