{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:11:30Z","timestamp":1783437090429,"version":"3.54.6"},"reference-count":111,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T00:00:00Z","timestamp":1539648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61772531"],"award-info":[{"award-number":["61772531"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1713212"],"award-info":[{"award-number":["U1713212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61572330"],"award-info":[{"award-number":["61572330"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61602319"],"award-info":[{"award-number":["61602319"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004791","name":"Shenzhen","doi-asserted-by":"publisher","award":["CYZZ20160304165036893"],"award-info":[{"award-number":["CYZZ20160304165036893"]}],"id":[{"id":"10.13039\/501100004791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/bib\/bby098","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T19:15:33Z","timestamp":1536779733000},"source":"Crossref","is-referenced-by-count":88,"title":["MicroRNA-small molecule association identification: from experimental results to computational models"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9028-5342","authenticated-orcid":false,"given":"Xing","family":"Chen","sequence":"first","affiliation":[{"name":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Na","family":"Guan","sequence":"additional","affiliation":[{"name":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Zhou","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,16]]},"reference":[{"key":"key\n\t\t\t\t20181016072254022_ref1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-1400-1_24","volume-title":"Chemical Properties of Antimicrobials and Their Uniqueness.","author":"Macielag","year":"2012"},{"key":"key\n\t\t\t\t20181016072254022_ref2","first-page":"48:ii","article-title":"Studies in natural products chemistry","volume":"37","author":"Rahman","year":"2014","journal-title":"Phytochemistry"},{"key":"key\n\t\t\t\t20181016072254022_ref3","first-page":"301","article-title":"Small-molecule inhibitors of protein-protein interactions: progressing toward the reality","volume":"3","author":"Arkin","year":"2004","journal-title":"Chem Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref4","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20181016072254022_ref5","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1021\/op400230q","article-title":"Introduction to biological and small molecule drug research and development: theory and case studies","volume":"17","author":"Laird","year":"2013","journal-title":"Org Process Res Dev"},{"key":"key\n\t\t\t\t20181016072254022_ref6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/534314a","article-title":"Can you teach old drugs new tricks?","volume":"534","author":"Nosengo","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrd.2016.85","article-title":"Trends in clinical success rates","volume":"15","author":"Smietana","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20181016072254022_ref8","doi-asserted-by":"crossref","DOI":"10.3390\/ph11020057","article-title":"Changing trends in computational drug repositioning","volume":"11","author":"Yella","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"key":"key\n\t\t\t\t20181016072254022_ref9","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/nbt1297-1318","article-title":"The role of innovation in drug development","volume":"15","author":"Drews","year":"1997","journal-title":"Nat Biotechnol"},{"key":"key\n\t\t\t\t20181016072254022_ref10","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1039\/c2mb00002d","article-title":"Drug-target interaction prediction by random walk on the heterogeneous network","volume":"8","author":"Chen","year":"2012","journal-title":"Mol Biosyst"},{"key":"key\n\t\t\t\t20181016072254022_ref11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/bib\/bbv066","article-title":"Drug-target interaction prediction: databases, web servers and computational models","volume":"17","author":"Chen","year":"2016","journal-title":"Brief Bioinform"},{"key":"key\n\t\t\t\t20181016072254022_ref12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrd892","article-title":"The druggable genome","volume":"1","author":"Hopkins","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20181016072254022_ref13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrm1129","article-title":"Killing the messenger: short RNAs that silence gene expression","volume":"4","author":"Dykxhoorn","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref14","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/omi.2014.0018","article-title":"Pharmacomicrobiomics: the impact of human microbiome variations on systems pharmacology and personalized therapeutics","volume":"18","author":"Elrakaiby","year":"2014","journal-title":"OMICS"},{"key":"key\n\t\t\t\t20181016072254022_ref15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/genetics\/96.2.435","article-title":"Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans","volume":"96","author":"Horvitz","year":"1980","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20181016072254022_ref16","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20181016072254022_ref17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181016072254022_ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/PPO.0b013e318250c001","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"18","author":"Croce","year":"2012","journal-title":"Cancer J"},{"key":"key\n\t\t\t\t20181016072254022_ref19","first-page":"53","article-title":"ONCOMIRS - \u201cMicroRNAs with a role in cancer\u201d","volume-title":"Contemp Math.","author":"Mir","year":"1993"},{"key":"key\n\t\t\t\t20181016072254022_ref20","article-title":"MicroRNAs and complex diseases: from experimental results to computational models","author":"Chen","year":"2017","journal-title":"Brief Bioinform"},{"key":"key\n\t\t\t\t20181016072254022_ref21","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/nature07299","article-title":"MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation","volume":"455","author":"Thomson","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrg3162","article-title":"MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship","volume":"13","author":"Pasquinelli","year":"2012","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20181016072254022_ref23","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/ijc.25818","article-title":"Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets","volume":"129","author":"Wang","year":"2011","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t20181016072254022_ref24","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.cell.2010.01.007","article-title":"miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts","volume":"140","author":"Eiring","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181016072254022_ref25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm3611","article-title":"Diversifying microRNA sequence and function","volume":"14","author":"Ameres","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20181016072254022_ref27","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.cell.2009.04.040","article-title":"SnapShot: MicroRNAs in cancer","volume":"137","author":"Spizzo","year":"2009","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181016072254022_ref28","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4103\/1673-5374.135333","article-title":"Overexpression of microRNA-124 promotes the neuronal differentiation of bone marrow-derived mesenchymal stem cells","volume":"9","author":"Zou","year":"2014","journal-title":"Neural Regen Res"},{"key":"key\n\t\t\t\t20181016072254022_ref29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1101\/sqb.2006.71.006","article-title":"Architecture of a MicroRNA-controlled gene regulatory network that diversifies neuronal cell fates","volume":"71","author":"Hobert","year":"2006","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature03817","article-title":"Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis","volume":"436","author":"Zhao","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref31","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1152\/physiolgenomics.90268.2008","article-title":"MicroRNA-127 modulates fetal lung development","volume":"37","author":"Bhaskaran","year":"2009","journal-title":"Physiol Genomics"},{"key":"key\n\t\t\t\t20181016072254022_ref32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1208\/s12248-009-9145-9","article-title":"Therapeutic microRNA strategies in human cancer","volume":"11","author":"Li","year":"2009","journal-title":"AAPS J"},{"key":"key\n\t\t\t\t20181016072254022_ref33","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature08725","article-title":"Opposing microRNA families regulate self-renewal in mouse embryonic stem cells","volume":"463","author":"Melton","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 regulates self renewal and tumorigenicity of breast cancer cells","volume":"131","author":"Yu","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20181016072254022_ref35","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0065-2776(09)01204-8","article-title":"Micromanagers of immune cell fate and function","volume":"102","author":"Petrocca","year":"2009","journal-title":"Adv Immunol"},{"key":"key\n\t\t\t\t20181016072254022_ref36","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O'Connell","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref37","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc2867","article-title":"Genetic variation in microRNA networks: the implications for cancer research","volume":"10","author":"Ryan","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20181016072254022_ref39","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1073\/pnas.0602266103","article-title":"Pre-B cell proliferation and lymphoblastic leukemia\/high-grade lymphoma in E(mu)-miR155 transgenic mice","volume":"103","author":"Costinean","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref40","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","article-title":"A microRNA polycistron as a potential human oncogene","volume":"435","author":"He","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pathol.4.110807.092222","article-title":"MicroRNAs in cancer","volume":"4","author":"Lee","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"key\n\t\t\t\t20181016072254022_ref42","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1073\/pnas.0712321105","article-title":"Suppression of non-small cell lung tumor development by the let-7 microRNA family","volume":"105","author":"Kumar","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref43","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cub.2007.06.068","article-title":"p53-mediated activation of miRNA34 candidate tumor-suppressor genes","volume":"17","author":"Bommer","year":"2007","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005912","article-title":"LRSSLMDA: Laplacian regularized sparse subspace learning for MiRNA-Disease association prediction","volume":"13","author":"Chen","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref45","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/gbe\/evw301","article-title":"Systematic analyses and prediction of human drug side effect associated proteins from the perspective of protein evolution","volume":"9","author":"Begum","year":"2017","journal-title":"Genome Biol Evol"},{"key":"key\n\t\t\t\t20181016072254022_ref46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41419-017-0003-x","article-title":"EGBMMDA: extreme gradient boosting machine for MiRNA-Disease association prediction","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis"},{"key":"key\n\t\t\t\t20181016072254022_ref47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006418","article-title":"MDHGI: matrix decomposition and heterogeneous graph inference for miRNA-disease association prediction","volume":"14","author":"Chen","year":"2018","journal-title":"PLoS Comput Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref48","first-page":"807","article-title":"ELLPMDA: ensemble learning and link prediction for miRNA-Disease association prediction","volume-title":"RNA Biol","author":"Chen","year":"2018"},{"key":"key\n\t\t\t\t20181016072254022_ref49","first-page":"1","article-title":"RKNNMDA: ranking-based KNN for MiRNA-Disease association prediction","author":"Chen","year":"2017","journal-title":"RNA Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref50","doi-asserted-by":"crossref","first-page":"21106","DOI":"10.1038\/srep21106","article-title":"WBSMDA: within and between score for MiRNA-Disease association prediction","volume":"6","author":"Chen","year":"2016","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20181016072254022_ref51","doi-asserted-by":"crossref","first-page":"21187","DOI":"10.18632\/oncotarget.15061","article-title":"MCMDA: matrix completion for MiRNA-disease association prediction","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20181016072254022_ref52","doi-asserted-by":"crossref","article-title":"Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","author":"Calin","DOI":"10.1073\/pnas.242606799"},{"key":"key\n\t\t\t\t20181016072254022_ref53","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nrd4140","article-title":"MicroRNAs and other non-coding RNAs as targets for anticancer drug development","volume":"12","author":"Ling","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20181016072254022_ref54","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"key\n\t\t\t\t20181016072254022_ref55","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1373\/clinchem.2015.240036","article-title":"Downregulation of miR-15a and miR-16-1 at 13q14 in chronic lymphocytic leukemia","volume":"62","author":"Acunzo","year":"2016","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t20181016072254022_ref56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref57","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1158\/0008-5472.CAN-04-0637","article-title":"Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival","volume":"64","author":"Takamizawa","year":"2004","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20181016072254022_ref58","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2006-12-062398","article-title":"Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia","volume":"109","author":"Fulci","year":"2007","journal-title":"Blood"},{"key":"key\n\t\t\t\t20181016072254022_ref59","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","article-title":"Unique microRNA molecular profiles in lung cancer diagnosis and prognosis","volume":"9","author":"Bowman","year":"2006","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20181016072254022_ref60","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1200\/JCO.2005.05.5194","article-title":"MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior","volume":"24","author":"Roldo","year":"2006","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t20181016072254022_ref61","first-page":"1358","article-title":"miR-21 plays pivotal role in gastric cancer pathogenesis and progression","author":"Zhang","year":"2008"},{"key":"key\n\t\t\t\t20181016072254022_ref62","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/ATVBAHA.112.300144","article-title":"MicroRNAs in metabolic disease","volume":"33","author":"Fern\u00e1ndezhernando","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref63","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1172\/JCI63539","article-title":"Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver","volume":"122","author":"Hsu","year":"2012","journal-title":"J Clin Investig"},{"key":"key\n\t\t\t\t20181016072254022_ref64","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1073\/pnas.1005191107","article-title":"miR-33 links SREBP-2 induction to repression of sterol transporters","volume":"107","author":"Marquart","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref65","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref66","doi-asserted-by":"crossref","first-page":"21075","DOI":"10.1073\/pnas.1118922109","article-title":"Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs","volume":"108","author":"Frost","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181016072254022_ref67","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nature10112","article-title":"MicroRNAs 103 and 107 regulate insulin sensitivity","volume":"474","author":"Trajkovski","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181016072254022_ref68","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C Virus RNA abundance by a liver-specific MicroRNA","volume":"309","author":"Jopling","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20181016072254022_ref69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.chom.2008.05.013","article-title":"Position-dependent function for a tandem microRNA miR-122-binding site located in the hepatitis C virus RNA genome","volume":"4","author":"Jopling","year":"2008","journal-title":"Cell Host Microbe"},{"key":"key\n\t\t\t\t20181016072254022_ref70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2010.02.005","article-title":"The role of microRNA in rheumatoid arthritis and other autoimmune diseases","volume":"136","author":"Furer","year":"2010","journal-title":"Clin Immunol"},{"key":"key\n\t\t\t\t20181016072254022_ref71","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/art.24475","article-title":"MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"60","author":"Nakamachi","year":"2009","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20181016072254022_ref72","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrfmmm.2011.02.002","article-title":"MicroRNAs in inflammation and response to injuries induced by environmental pollution","volume":"717","author":"Sonkoly","year":"2011","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20181016072254022_ref73","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1164\/rccm.200903-0325OC","article-title":"Down-regulation of miR-133a contributes to up-regulation of Rhoa in bronchial smooth muscle cells","volume":"180","author":"Chiba","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20181016072254022_ref74","doi-asserted-by":"crossref","first-page":"29336","DOI":"10.1074\/jbc.M110.101147","article-title":"Mechanical stretch up-regulates MicroRNA-26a and induces human airway smooth muscle hypertrophy by suppressing glycogen synthase kinase-3","volume":"285","author":"Mohamed","year":"2010","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20181016072254022_ref75","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/j.bmcl.2015.07.016","article-title":"Aryl amide small-molecule inhibitors of microRNA miR-21 function","volume":"25","author":"Naro","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"key\n\t\t\t\t20181016072254022_ref76","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1021\/ja910275u","article-title":"Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma","volume":"132","author":"Young","year":"2010","journal-title":"J Am Chem Soc"},{"key":"key\n\t\t\t\t20181016072254022_ref77","first-page":"7482","article-title":"Small molecule inhibitors of MicroRNA","volume":"47","author":"Huang","year":"2016","journal-title":"Angew Chemie"},{"key":"key\n\t\t\t\t20181016072254022_ref78","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/anie.201106455","article-title":"The tuberculosis drug streptomycin as a potential cancer therapeutic: inhibition of miR-21 function by directly targeting its precursor","volume":"51","author":"Bose","year":"2012","journal-title":"Angew Chemie"},{"key":"key\n\t\t\t\t20181016072254022_ref79","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1158\/0008-5472.CAN-13-0280","article-title":"AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression","volume":"73","author":"Shi","year":"2013","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20181016072254022_ref80","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.phrs.2007.07.001","article-title":"Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro","volume":"56","author":"Rossi","year":"2007","journal-title":"Pharmacol Res"},{"key":"key\n\t\t\t\t20181016072254022_ref81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/nat.2011.0332","article-title":"A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys","volume":"22","author":"Hildebrandt-Eriksen","year":"2012","journal-title":"Nucleic Acid Ther"},{"key":"key\n\t\t\t\t20181016072254022_ref82","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcb.20982","article-title":"Downregulation of miR-122 in the rodent and human hepatocellular carcinomas","volume":"99","author":"Kutay","year":"2006","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20181016072254022_ref83","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.bmcl.2011.10.061","article-title":"aza-Flavanones as potent cross-species microRNA inhibitors that arrest cell cycle","volume":"22","author":"Chandrasekhar","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"key\n\t\t\t\t20181016072254022_ref84","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1016\/j.bmcl.2017.10.052","article-title":"RNA as a small molecule druggable target","volume":"27","author":"Rizvi","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"key\n\t\t\t\t20181016072254022_ref85","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/1087057112439606","article-title":"High-throughput luciferase reporter assay for small-molecule inhibitors of MicroRNA function","volume":"17","author":"Connelly","year":"2012","journal-title":"J Biomol Screen"},{"key":"key\n\t\t\t\t20181016072254022_ref86","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1021\/cb300650y","article-title":"A molecular-beacon-based screen for small molecule inhibitors of miRNA maturation","volume":"8","author":"Bose","year":"2013","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref87","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bmc.2007.04.055","article-title":"A fluorescence probe for assaying micro RNA maturation","volume":"16","author":"Davies","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"key\n\t\t\t\t20181016072254022_ref88","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/bioinformatics\/bts698","article-title":"SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression","volume":"29","author":"Liu","year":"2013","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181016072254022_ref89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jgg.2017.04.003","article-title":"mTD: a database of microRNAs affecting therapeutic effects of drugs","volume":"44","author":"Chen","year":"2017","journal-title":"J Genet Genomics"},{"key":"key\n\t\t\t\t20181016072254022_ref90","doi-asserted-by":"crossref","first-page":"bax057","DOI":"10.1093\/database\/bax057","article-title":"NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations","volume":"2017","author":"Chen","year":"2017","journal-title":"Database"},{"key":"key\n\t\t\t\t20181016072254022_ref91","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12859-016-1002-0","article-title":"ChemiRs: a web application for microRNAs and chemicals","volume":"17","author":"Su","year":"2016","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20181016072254022_ref92","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1021\/acschembio.6b00001","article-title":"Inforna 2.0: a platform for the sequence-based design of small molecules targeting structured RNAs","volume":"11","author":"Disney","year":"2016","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref93","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/clpt.2010.46","article-title":"Targeting microRNAs with small molecules: from dream to reality","volume":"87","author":"Zhang","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t20181016072254022_ref94","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/srep00282","article-title":"Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses","volume":"2","author":"Jiang","year":"2012","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20181016072254022_ref95","doi-asserted-by":"crossref","first-page":"20131057","DOI":"10.1098\/rsif.2013.1057","article-title":"Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease","volume":"11","author":"Meng","year":"2014","journal-title":"J R Soc Interface"},{"key":"key\n\t\t\t\t20181016072254022_ref96","doi-asserted-by":"crossref","first-page":"38658","DOI":"10.18632\/oncotarget.9577","article-title":"Identification of associations between small molecule drugs and miRNAs based on functional similarity","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20181016072254022_ref97","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1758-2946-4-16","article-title":"Computational analysis and predictive modeling of small molecule modulators of microRNA","volume":"4","author":"Jamal","year":"2012","journal-title":"J Cheminform"},{"key":"key\n\t\t\t\t20181016072254022_ref98","doi-asserted-by":"crossref","first-page":"W623","DOI":"10.1093\/nar\/gkp456","article-title":"PubChem: a public information system for analyzing bioactivities of small molecules","volume":"37","author":"Wang","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20181016072254022_ref99","doi-asserted-by":"crossref","first-page":"45584","DOI":"10.18632\/oncotarget.10052","article-title":"Network-based identification of microRNAs as potential pharmacogenomic biomarkers for anticancer drugs","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t20181016072254022_ref100","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1093\/bioinformatics\/btv417","article-title":"Identifying novel associations between small molecules and miRNAs based on integrated molecular networks","volume":"31","author":"Lv","year":"2015","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181016072254022_ref101","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/msb.2011.26","article-title":"PREDICT: a method for inferring novel drug indications with application to personalized medicine","volume":"7","author":"Gottlieb","year":"2011","journal-title":"Mol Syst Biol"},{"key":"key\n\t\t\t\t20181016072254022_ref102","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1098\/rsif.2011.0551","article-title":"A novel method to quantify gene set functional association based on gene ontology","volume":"9","author":"Lv","year":"2012","journal-title":"J R Soc Interface"},{"key":"key\n\t\t\t\t20181016072254022_ref103","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1021\/ja036030u","article-title":"Development of a chemical structure comparison method for integrated analysis of chemical and genomic information in the metabolic pathways","volume":"125","author":"Hattori","year":"2003","journal-title":"J Am Chem Soc"},{"key":"key\n\t\t\t\t20181016072254022_ref104","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13321-018-0284-9","article-title":"Inferring potential small molecule-miRNA association based on triple layer heterogeneous network","volume":"10","author":"Qu","year":"2018","journal-title":"J Chem"},{"key":"key\n\t\t\t\t20181016072254022_ref105","first-page":"53","article-title":"Drug target predictions based on heterogeneous graph inference","volume":"18","author":"Wang","year":"2013","journal-title":"Pacific Symp Biocomput"},{"key":"key\n\t\t\t\t20181016072254022_ref106","doi-asserted-by":"crossref","first-page":"bbw060","DOI":"10.1093\/bib\/bbw060","article-title":"Long non-coding RNAs and complex diseases: from experimental results to computational models","author":"Chen","year":"2016","journal-title":"Brief Bioinform"},{"key":"key\n\t\t\t\t20181016072254022_ref107","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/bioinformatics\/btt426","article-title":"Novel human lncRNA-disease association inference based on lncRNA expression profiles","volume":"29","author":"Chen","year":"2013","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181016072254022_ref108","doi-asserted-by":"crossref","first-page":"bax057","DOI":"10.1093\/database\/bax057","article-title":"NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations","volume":"2017","author":"Chen","year":"2017","journal-title":"Database"},{"key":"key\n\t\t\t\t20181016072254022_ref109","doi-asserted-by":"crossref","first-page":"6655","DOI":"10.1038\/s41598-017-06897-3","article-title":"The LncRNA connectivity map: using LncRNA signatures to connect small molecules, LncRNAs, and diseases","volume":"7","author":"Yang","year":"2017","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20181016072254022_ref110","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1158\/1538-7445.AM2014-5203","article-title":"Abstract 5203: long non-coding RNA H19 as a novel therapeutic target for pancreatic cancer","volume":"74","author":"Yoshimura","year":"2014","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20181016072254022_ref111","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1158\/1538-7445.AM2016-1598","article-title":"Abstract 1598: LncRNA AK001796 as a therapeutic target in aggressive breast cancers","volume":"76","author":"Kumar","year":"2016","journal-title":"Cancer Res"}],"container-title":["Briefings in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/bib\/advance-article-pdf\/doi\/10.1093\/bib\/bby098\/26076353\/bby098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T05:37:45Z","timestamp":1662010665000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bib\/advance-article\/doi\/10.1093\/bib\/bby098\/5122726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,16]]},"references-count":111,"URL":"https:\/\/doi.org\/10.1093\/bib\/bby098","relation":{},"ISSN":["1467-5463","1477-4054"],"issn-type":[{"value":"1467-5463","type":"print"},{"value":"1477-4054","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,16]]}}}