{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:38:19Z","timestamp":1774499899267,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0505700"],"award-info":[{"award-number":["2017YFA0505700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Depression is a seriously disabling psychiatric disorder with a significant burden of disease. Metabolic abnormalities have been widely reported in depressed patients and animal models. However, there are few systematic efforts that integrate meaningful biological insights from these studies. Herein, available metabolic knowledge in the context of depression was integrated to provide a systematic and panoramic view of metabolic characterization. After screening more than 10\u00a0000 citations from five electronic literature databases and five metabolomics databases, we manually curated 5675 metabolite entries from 464 studies, including human, rat, mouse and non-human primate, to develop a new metabolite-disease association database, called MENDA (http:\/\/menda.cqmu.edu.cn:8080\/index.php). The standardized data extraction process was used for data collection, a multi-faceted annotation scheme was developed, and a user-friendly search engine and web interface were integrated for database access. To facilitate data analysis and interpretation based on MENDA, we also proposed a systematic analytical framework, including data integration and biological function analysis. Case studies were provided that identified the consistently altered metabolites using the vote-counting method, and that captured the underlying molecular mechanism using pathway and network analyses. Collectively, we provided a comprehensive curation of metabolic characterization in depression. Our model of a specific psychiatry disorder may be replicated to study other complex diseases.<\/jats:p>","DOI":"10.1093\/bib\/bbz055","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:10:11Z","timestamp":1555585811000},"page":"1455-1464","source":"Crossref","is-referenced-by-count":43,"title":["MENDA: a comprehensive curated resource of metabolic characterization in depression"],"prefix":"10.1093","volume":"21","author":[{"given":"Juncai","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Medical Informatics, Chongqing Medical University, Chongqing, China"},{"name":"Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA"}]},{"given":"Yiyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Lu","family":"Tian","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Siwen","family":"Gui","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Xiaogang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Chu","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Medical Informatics, Chongqing Medical University, Chongqing, China"}]},{"given":"Shaohua","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Xuemian","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Lanxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Lining","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Peng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Jianjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Ke","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Chanjuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Haiyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, China"}]},{"given":"Peng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China"},{"name":"Chongqing Key Laboratory of Neurobiology, Chongqing, 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