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This complicates the management of molecular network layouts and hinders their reuse and extension. In this paper, we present a high-level overview of the layout formats in systems biology, focusing on their commonalities and differences, review their support in existing software tools, libraries and repositories and finally introduce a new conversion module within the MINERVA platform. The module is available via a REST API and offers, besides the ability to convert between layout-aware systems biology formats, the possibility to export layouts into several graphical formats. The module enables conversion of very large networks with thousands of elements, such as disease maps or metabolic reconstructions, rendering it widely applicable in systems biology.<\/jats:p>","DOI":"10.1093\/bib\/bbz067","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:08:39Z","timestamp":1557918519000},"page":"1249-1260","source":"Crossref","is-referenced-by-count":25,"title":["Closing the gap between formats for storing layout information in systems biology"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-0557","authenticated-orcid":false,"given":"David","family":"Hoksza","sequence":"first","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6, avenue du Swing L-4367 Belvaux, Luxembourg"},{"name":"Faculty of Mathematics and Physics, Charles University, Malostransk\u00e9 n\u00e1m. 25, 118 00 Prague, Czech 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