{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:41:41Z","timestamp":1781934101928,"version":"3.54.5"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Targets project"},{"name":"EMBL core funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Genome-wide association studies (GWAS) are a powerful method to detect even weak associations between variants and phenotypes; however, many of the identified associated variants are in non-coding regions, and presumably influence gene expression regulation. Identifying potential drug targets, i.e. causal protein-coding genes, therefore, requires crossing the genetics results with functional data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We present a novel data integration pipeline that analyses GWAS results in the light of experimental epigenetic and cis-regulatory datasets, such as ChIP-Seq, Promoter-Capture Hi-C or eQTL, and presents them in a single report, which can be used for inferring likely causal genes. This pipeline was then fed into an interactive data resource.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>The analysis code is available at www.github.com\/Ensembl\/postgap and the interactive data browser at postgwas.opentargets.io.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa020","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T20:10:08Z","timestamp":1578600608000},"page":"2936-2937","source":"Crossref","is-referenced-by-count":27,"title":["The open targets post-GWAS analysis pipeline"],"prefix":"10.1093","volume":"36","author":[{"given":"Gareth","family":"Peat","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jones","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Wellcome Sanger Institute, Wellcome Genome Campus , Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nuhn","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Marug\u00e1n","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Newell","sequence":"additional","affiliation":[{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"GSK, Medicines Research Center , Stevenage SG1 2NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Dunham","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zerbino","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute , Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"},{"name":"Open Targets, EBI South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"2023013111483053900_btaa020-B1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"key":"2023013111483053900_btaa020-B2","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res"},{"key":"2023013111483053900_btaa020-B3","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1126\/science.1069516","article-title":"Genetic dissection of transcriptional regulation in budding yeast","volume":"296","author":"Brem","year":"2002","journal-title":"Science"},{"key":"2023013111483053900_btaa020-B4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrd4309","article-title":"Lessons learned from the fate of AstraZeneca\u2019s drug pipeline: a five-dimensional framework","volume":"13","author":"Cook","year":"2014","journal-title":"Nat. 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