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We describe a method for distinguishing when lack of covariation signal can be taken as evidence against a conserved RNA structure, as opposed to when a sequence alignment merely has insufficient variation to detect covariations. We find that alignments for several long non-coding RNAs previously shown to lack covariation support do have adequate covariation detection power, providing additional evidence against their proposed conserved structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The R-scape web server is at eddylab.org\/R-scape, with a link to download the source code.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa080","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T15:12:41Z","timestamp":1580310761000},"page":"3072-3076","source":"Crossref","is-referenced-by-count":100,"title":["Estimating the power of sequence covariation for detecting conserved RNA structure"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2084-269X","authenticated-orcid":false,"given":"Elena","family":"Rivas","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology , Harvard University, Cambridge, MA 02138, USA"}]},{"given":"Jody","family":"Clements","sequence":"additional","affiliation":[{"name":"Janelia Research Campus , Howard Hughes Medical Institute, Ashburn, VA 20147, USA"}]},{"given":"Sean R","family":"Eddy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology , Harvard University, Cambridge, MA 02138, USA"},{"name":"Howard Hughes Medical Institute , Chevy Chase, MD 20815, USA"},{"name":"John A. 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