{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T18:24:58Z","timestamp":1776018298769,"version":"3.50.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFC1200200"],"award-info":[{"award-number":["2016YFC1200200"]}]},{"name":"National Key Plan for Scientific Research and Development of China","award":["2016YFD0500300"],"award-info":[{"award-number":["2016YFD0500300"]}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2018JJ3039"],"award-info":[{"award-number":["2018JJ3039"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31500126"],"award-info":[{"award-number":["31500126"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671371"],"award-info":[{"award-number":["31671371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016-I2M-1-005"],"award-info":[{"award-number":["2016-I2M-1-005"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Newly emerging influenza viruses keep challenging global public health. To evaluate the potential risk of the viruses, it is critical to rapidly determine the phenotypes of the viruses, including the antigenicity, host, virulence and drug resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we built FluPhenotype, a one-stop platform to rapidly determinate the phenotypes of the influenza A viruses. The input of FluPhenotype is the complete or partial genomic\/protein sequences of the influenza A viruses. The output presents five types of information about the viruses: (i) sequence annotation including the gene and protein names as well as the open reading frames, (ii) potential hosts and human-adaptation-associated amino acid markers, (iii) antigenic and genetic relationships with the vaccine strains of different HA subtypes, (iv) mammalian virulence-related amino acid markers and (v) drug resistance-related amino acid markers. FluPhenotype will be a useful bioinformatic tool for surveillance and early warnings of the newly emerging influenza A viruses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>It is publicly available from: http:\/\/www.computationalbiology.cn : 18888\/IVEW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa083","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T20:10:04Z","timestamp":1580847004000},"page":"3251-3253","source":"Crossref","is-referenced-by-count":9,"title":["FluPhenotype\u2014a one-stop platform for early warnings of the influenza A virus"],"prefix":"10.1093","volume":"36","author":[{"given":"Congyu","family":"Lu","sequence":"first","affiliation":[{"name":"College of Biology , Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zena","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Biology , Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Changsha Qiangze Biotech Co. , Ltd., Changsha, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Biology , Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Biology , Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizong","family":"Deng","sequence":"additional","affiliation":[{"name":"Center for Systems Medicine , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"},{"name":"Suzhou Institute of Systems Medicine , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjun","family":"Du","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) , Sun Yat-sen University, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiping","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Systems Medicine , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"},{"name":"Suzhou Institute of Systems Medicine , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention , China CDC, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institute for Viral Disease Control and Prevention , China CDC, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelong","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) , Sun Yat-sen University, Guangdong 510275, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taijiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Systems Medicine , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China"},{"name":"Suzhou Institute of Systems Medicine , Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousong","family":"Peng","sequence":"additional","affiliation":[{"name":"College of Biology , Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha 410082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"2023013112031864800_btaa083-B1","year":"2012"},{"key":"2023013112031864800_btaa083-B2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ncomms1710","article-title":"Mapping of H3N2 influenza antigenic evolution in China reveals a strategy for vaccine strain recommendation","volume":"3","author":"Du","year":"2012","journal-title":"Nat. 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