{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:55:33Z","timestamp":1777542933466,"version":"3.51.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"22-23","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EFRE-Program"},{"name":"European Territorial Cooperation","award":["2014\u20132020"],"award-info":[{"award-number":["2014\u20132020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The generation of high-quality assemblies, even for large eukaryotic genomes, has become a routine task for many biologists thanks to recent advances in sequencing technologies. However, the annotation of these assemblies\u2014a crucial step toward unlocking the biology of the organism of interest\u2014has remained a complex challenge that often requires advanced bioinformatics expertise.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Here, we present MOSGA (Modular Open-Source Genome Annotator), a genome annotation framework for eukaryotic genomes with a user-friendly web-interface that generates and integrates annotations from various tools. The aggregated results can be analyzed with a fully integrated genome browser and are provided in a format ready for submission to NCBI. MOSGA is built on a portable, customizable and easily extendible Snakemake backend, and thus, can be tailored to a wide range of users and projects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>We provide MOSGA as a web service at https:\/\/mosga.mathematik.uni-marburg.de and as a docker container at registry.gitlab.com\/mosga\/mosga: latest. Source code can be found at https:\/\/gitlab.com\/mosga\/mosga<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa1003","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T14:35:16Z","timestamp":1605710116000},"page":"5514-5515","source":"Crossref","is-referenced-by-count":14,"title":["MOSGA: Modular Open-Source Genome Annotator"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-7856","authenticated-orcid":false,"given":"Roman","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Marburg , 35032 Marburg, Germany"},{"name":"Department of Organic-Analytical Chemistry, TUM Campus Straubing , 94315 Straubing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-320X","authenticated-orcid":false,"given":"Thomas","family":"Hackl","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research , Heidelberg 69120, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-8254","authenticated-orcid":false,"given":"Georges","family":"Hattab","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Marburg , 35032 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-3626","authenticated-orcid":false,"given":"Matthias G","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research , Heidelberg 69120, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-8311","authenticated-orcid":false,"given":"Dominik","family":"Heider","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Marburg , 35032 Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"2023062707095391900_btaa1003-B1","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1093\/nar\/gkx642","article-title":"De novo pathway-based biomarker identification","volume":"45","author":"Alcaraz","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2023062707095391900_btaa1003-B2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bib\/5.1.39","article-title":"Swiss-Prot: juggling between evolution and stability","volume":"5","author":"Bairoch","year":"2004","journal-title":"Brief. 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