{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:07:09Z","timestamp":1771049229071,"version":"3.50.1"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Scientific Foundation of China","doi-asserted-by":"crossref","award":["31771471"],"award-info":[{"award-number":["31771471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation for Distinguished Young Scholar of Hebei Province","award":["C2017209244"],"award-info":[{"award-number":["C2017209244"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>RNA modifications play critical roles in a series of cellular and developmental processes. Knowledge about the distributions of RNA modifications in the transcriptomes will provide clues to revealing their functions. Since experimental methods are time consuming and laborious for detecting RNA modifications, computational methods have been proposed for this aim in the past five years. However, there are some drawbacks for both experimental and computational methods in simultaneously identifying modifications occurred on different nucleotides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To address such a challenge, in this article, we developed a new predictor called iMRM, which is able to simultaneously identify m6A, m5C, m1A, \u03c8 and A-to-I modifications in Homo sapiens, Mus musculus and Saccharomyces\u2002cerevisiae. In iMRM, the feature selection technique was used to pick out the optimal features. The results from both 10-fold cross-validation and jackknife test demonstrated that the performance of iMRM is superior to existing methods for identifying RNA modifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>A user-friendly web server for iMRM was established at http:\/\/www.bioml.cn\/XG_iRNA\/home. The off-line command-line version is available at https:\/\/github.com\/liukeweiaway\/iMRM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Contact<\/jats:title><jats:p>greatchen@ncst.edu.cn<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa155","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T20:20:09Z","timestamp":1582921209000},"page":"3336-3342","source":"Crossref","is-referenced-by-count":142,"title":["iMRM: a platform for simultaneously identifying multiple kinds of RNA modifications"],"prefix":"10.1093","volume":"36","author":[{"given":"Kewei","family":"Liu","sequence":"first","affiliation":[{"name":"School of Life Sciences , Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan 063009, China"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences , Center for Genomics and Computational Biology, North China University of Science and Technology, Tangshan 063009, China"},{"name":"Innovative Institute of Chinese Medicine and Pharmacy , Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}]}],"member":"286","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"2023062312015799400_btaa155-B1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ajhg.2012.03.021","article-title":"Mutations in NSUN2 cause autosomal-recessive intellectual disability","volume":"90","author":"Abbasi-Moheb","year":"2012","journal-title":"Am. 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