{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:33:39Z","timestamp":1779107619700,"version":"3.51.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41 GM103712"],"award-info":[{"award-number":["P41 GM103712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DA035778"],"award-info":[{"award-number":["P30 DA035778"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>QuartataWeb is a user-friendly server developed for polypharmacological and chemogenomics analyses. Users can easily obtain information on experimentally verified (known) and computationally predicted (new) interactions between 5494 drugs and 2807 human proteins in DrugBank, and between 315\u2009514 chemicals and 9457 human proteins in the STITCH database. In addition, QuartataWeb links targets to KEGG pathways and GO annotations, completing the bridge from drugs\/chemicals to function via protein targets and cellular pathways. It allows users to query a series of chemicals, drug combinations or multiple targets, to enable multi-drug, multi-target, multi-pathway analyses, toward facilitating the design of polypharmacological treatments for complex diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>QuartataWeb is freely accessible at http:\/\/quartata.csb.pitt.edu.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa210","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T04:44:57Z","timestamp":1585111497000},"page":"3935-3937","source":"Crossref","is-referenced-by-count":24,"title":["QuartataWeb: Integrated Chemical\u2013Protein-Pathway Mapping for Polypharmacology and Chemogenomics"],"prefix":"10.1093","volume":"36","author":[{"given":"Hongchun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Computational and Systems Biology School of Medicine"},{"name":"Research Center for Computer-Aided Drug Discovery, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Computational and Systems Biology School of Medicine"},{"name":"Drug Discovery Institute , University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Lansing","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Computational and Systems Biology School of Medicine"},{"name":"Drug Discovery Institute , University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4176","authenticated-orcid":false,"given":"Ivet","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Computational and Systems Biology School of Medicine"},{"name":"Drug Discovery Institute , University of Pittsburgh, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"2023063011485836100_btaa210-B1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1752-0509-9-S3-S4","article-title":"DT-Web: a web-based application for drug-target interaction and drug combination prediction through domain-tuned network-based inference","volume":"9","author":"Alaimo","year":"2015","journal-title":"BMC Syst. 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