{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:56:48Z","timestamp":1766401008667,"version":"3.37.3"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T00:00:00Z","timestamp":1585612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/R506229\/1"],"award-info":[{"award-number":["BB\/R506229\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>ScaffoldGraph (SG) is an open-source Python library and command-line tool for the generation and analysis of molecular scaffold networks and trees, with the capability of processing large sets of input molecules. With the increase in high-throughput screening data, scaffold graphs have proven useful for the navigation and analysis of chemical space, being used for visualization, clustering, scaffold-diversity analysis and active-series identification. Built on RDKit and NetworkX, SG integrates scaffold graph analysis into the growing scientific\/cheminformatics Python stack, increasing the flexibility and extendibility of the tool compared to existing software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>SG is freely available and released under the MIT licence at https:\/\/github.com\/UCLCheminformatics\/ScaffoldGraph.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa219","type":"journal-article","created":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T12:10:20Z","timestamp":1585138220000},"page":"3930-3931","source":"Crossref","is-referenced-by-count":24,"title":["ScaffoldGraph: an open-source library for the generation and analysis of molecular scaffold networks and scaffold trees"],"prefix":"10.1093","volume":"36","author":[{"given":"Oliver B","family":"Scott","sequence":"first","affiliation":[{"name":"Wolfson Institute of Biomedical Research , University College London, London WC1E 6BT, UK"}]},{"given":"A W","family":"Edith Chan","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Biomedical Research , University College London, London WC1E 6BT, UK"}]}],"member":"286","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"key":"2023063011483358700_btaa219-B1","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1021\/jm9602928","article-title":"The properties of known drugs. 1. 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