{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:48:51Z","timestamp":1774950531252,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>The outbreak of COVID-2019 initiated at Wuhan, China has become a global threat by rapid transmission and severe fatalities. Recent studies have uncovered whole genome sequence of SARS-CoV-2 (causing COVID-2019). In addition, lung metagenomic studies on infected patients revealed overrepresented Prevotella spp. producing certain proteins in abundance. We performed host\u2013pathogen protein\u2013protein interaction analysis between SARS-CoV-2 and overrepresented Prevotella proteins with human proteome. We also performed functional overrepresentation analysis of interacting proteins to understand their role in COVID-2019 severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>It was found that overexpressed Prevotella proteins can promote viral infection. As per the results, Prevotella proteins, but not viral proteins, are involved in multiple interactions with NF-kB, which is involved in increasing clinical severity of COVID-2019. Prevotella may have role in COVID-2019 outbreak and should be given importance for understanding disease mechanisms and improving treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa285","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T20:23:04Z","timestamp":1588191784000},"page":"4065-4069","source":"Crossref","is-referenced-by-count":73,"title":["COVID-2019-associated overexpressed <i>Prevotella<\/i> proteins mediated host\u2013pathogen interactions and their role in coronavirus outbreak"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-1841","authenticated-orcid":false,"given":"Abdul Arif","family":"Khan","sequence":"first","affiliation":[{"name":"Division of Microbiology , Indian Council of Medical Research-National AIDS Research Institute, Pune, Maharashtra 411026, India"}]},{"given":"Zakir","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine"},{"name":"Department of Biomedical Sciences , Cedars-Sinai Medical Centre, Los Angeles, CA 90048, USA"}]}],"member":"286","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"2023062300444498100_btaa285-B1","first-page":"baw103","article-title":"HPIDB 2.0: a curated database for host-pathogen interactions","volume":"2016","author":"Ammari","year":"2016","journal-title":"Database J. 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