{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:11:28Z","timestamp":1783437088114,"version":"3.54.6"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61873089"],"award-info":[{"award-number":["61873089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["201906130027"],"award-info":[{"award-number":["201906130027"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Motivation<\/jats:title><jats:p>Human microbes play critical roles in drug development and precision medicine. How to systematically understand the complex interaction mechanism between human microbes and drugs remains a challenge nowadays. Identifying microbe\u2013drug associations can not only provide great insights into understanding the mechanism, but also boost the development of drug discovery and repurposing. Considering the high cost and risk of biological experiments, the computational approach is an alternative choice. However, at present, few computational approaches have been developed to tackle this task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this work, we leveraged rich biological information to construct a heterogeneous network for drugs and microbes, including a microbe similarity network, a drug similarity network and a microbe\u2013drug interaction network. We then proposed a novel graph convolutional network (GCN)-based framework for predicting human Microbe\u2013Drug Associations, named GCNMDA. In the hidden layer of GCN, we further exploited the Conditional Random Field (CRF), which can ensure that similar nodes (i.e. microbes or drugs) have similar representations. To more accurately aggregate representations of neighborhoods, an attention mechanism was designed in the CRF layer. Moreover, we performed a random walk with restart-based scheme on both drug and microbe similarity networks to learn valuable features for drugs and microbes, respectively. Experimental results on three different datasets showed that our GCNMDA model consistently achieved better performance than seven state-of-the-art methods. Case studies for three microbes including SARS-CoV-2 and two antimicrobial drugs (i.e. Ciprofloxacin and Moxifloxacin) further confirmed the effectiveness of GCNMDA in identifying potential microbe\u2013drug associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Availability and implementation<\/jats:title><jats:p>Python codes and dataset are available at: https:\/\/github.com\/longyahui\/GCNMDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Supplementary information<\/jats:title><jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p><\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa598","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T11:21:25Z","timestamp":1592652085000},"page":"4918-4927","source":"Crossref","is-referenced-by-count":156,"title":["Predicting human microbe\u2013drug associations via graph convolutional network with conditional random field"],"prefix":"10.1093","volume":"36","author":[{"given":"Yahui","family":"Long","sequence":"first","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Changsha 410000, China"},{"name":"School of Computer Science and Engineering, Nanyang Technological University , Singapore 639798, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-3600","authenticated-orcid":false,"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Keong","family":"Kwoh","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Nanyang Technological University , Singapore 639798, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Computer Science and Electronic Engineering, Hunan University , Changsha 410000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[{"name":"Machine Intellection Department, Institute for Infocomm Research, Agency for Science, Technology and Research (A*STAR) , Singapore 138632, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"key":"2023062408060295000_btaa598-B1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1574-695X.2011.00921.x","article-title":"Isolation and characterization of small qnrs1-carrying plasmids from imported seafood isolates of Salmonella enterica that are highly similar to plasmids of clinical isolates","volume":"64","author":"Akiyama","year":"2012","journal-title":"FEMS Immunol. 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