{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:16:24Z","timestamp":1778336184322,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"19","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agriculture Seed Project of Shandong Province","award":["2019LZGC011"],"award-info":[{"award-number":["2019LZGC011"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["31872344"],"award-info":[{"award-number":["31872344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shandong Provincial Postdoctoral Program for Innovative Talents"},{"name":"Wellcome Trust Case-Control Consortium","award":["076113"],"award-info":[{"award-number":["076113"]}]},{"name":"Wellcome Trust Case-Control Consortium","award":["085475"],"award-info":[{"award-number":["085475"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>We have developed a rapid mixed model algorithm for exhaustive genome-wide epistatic association analysis by controlling multiple polygenic effects. Our model can simultaneously handle additive by additive epistasis, dominance by dominance epistasis and additive by dominance epistasis, and account for intrasubject fluctuations due to individuals with repeated records. Furthermore, we suggest a simple but efficient approximate algorithm, which allows the examination of all pairwise interactions in a remarkably fast manner of linear with population size. Simulation studies are performed to investigate the properties of REMMAX. Application to publicly available yeast and human data has showed that our mixed model-based method has similar performance with simple linear model on computational efficiency. It took less than 40\u2009h for the pairwise analysis of 5000 individuals genotyped with roughly 350\u00a0000 SNPs with five threads on Intel Xeon E5 2.6\u2009GHz CPU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Source codes are freely available at https:\/\/github.com\/chaoning\/GMAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa610","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T15:16:09Z","timestamp":1593011769000},"page":"4833-4837","source":"Crossref","is-referenced-by-count":33,"title":["Rapid epistatic mixed-model association studies by controlling multiple polygenic effects"],"prefix":"10.1093","volume":"36","author":[{"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University , Beijing 100193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Botany and Plant Science, University of California , Riverside, CA 92521, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8247-1700","authenticated-orcid":false,"given":"Chao","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Shandong Agricultural University , Tai\u2019an 271018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"2023062408070826100_btaa610-B1","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1038\/ncomms9712","article-title":"Genetic interactions contribute less than additive effects to quantitative trait variation in yeast","volume":"6","author":"Bloom","year":"2015","journal-title":"Nat. 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