{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:32:58Z","timestamp":1765888378494,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013060","name":"European Molecular Biology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EMBL International PhD programme"},{"name":"lowship of the EMBL International Postdoc programme"},{"name":"Marie Sk\u0142odowska","award":["664726"],"award-info":[{"award-number":["664726"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>Rtpca is an R package implementing methods for inferring protein\u2013protein interactions (PPIs) based on thermal proteome profiling experiments of a single condition or in a differential setting via an approach called thermal proximity coaggregation. It offers user-friendly tools to explore datasets for their PPI predictive performance and easily integrates with available R packages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and implementation<\/jats:title>\n                  <jats:p>Rtpca is available from Bioconductor (https:\/\/bioconductor.org\/packages\/Rtpca).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa682","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T19:24:53Z","timestamp":1595445893000},"page":"431-433","source":"Crossref","is-referenced-by-count":23,"title":["Rtpca: an R package for differential thermal proximity coaggregation analysis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-2817","authenticated-orcid":false,"given":"Nils","family":"Kurzawa","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, Genome Biology Unit , 69117 Heidelberg, Germany"},{"name":"Candidate for Joint PhD Between EMBL and Heidelberg University, Faculty of Biosciences , 69120 Heidelberg, Germany"}]},{"given":"Andr\u00e9","family":"Mateus","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, Genome Biology Unit , 69117 Heidelberg, Germany"}]},{"given":"Mikhail M","family":"Savitski","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, Genome Biology Unit , 69117 Heidelberg, Germany"}]}],"member":"286","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"2023051603575900900_btaa682-B1","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cell.2018.03.053","article-title":"Pervasive protein thermal stability variation during the cell cycle","volume":"173","author":"Becher","year":"2018","journal-title":"Cell"},{"key":"2023051603575900900_btaa682-B2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/msb4100134","article-title":"Large-scale mapping of human protein\u2013protein interactions by mass spectrometry","volume":"3","author":"Ewing","year":"2007","journal-title":"Mol. 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