{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:33:59Z","timestamp":1772138039709,"version":"3.50.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HE7707\/5-1"],"award-info":[{"award-number":["HE7707\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Influenza viruses are a cause of large outbreaks and pandemics with high death tolls. A key obstacle is that flu vaccines have inconsistent performance, in the best cases up to 60% effectiveness, but it can be as low as 10%. Uncovering the hidden pathways of how antibodies (Abs) induced by one influenza strain are effective against another, cross-reaction, is a central vexation for the design of universal flu vaccines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We conceive a stochastic model that successfully represents the antibody cross-reactive data from mice infected with H3N2 influenza strains and further validation with cross-reaction data of H1N1 strains. Using a High-Performance Computing cluster, several aspects and parameters in the model were tested. Computational simulations highlight that changes in time of infection and the B-cells population are relevant, however, the affinity threshold of B-cells between consecutive infections is a necessary condition for the successful Abs cross-reaction. Our results suggest a 3-D reformulation of the current influenza antibody landscape for the representation and modeling of cross-reactive data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The full code as a testing\/simulation platform is freely available here: https:\/\/github.com\/systemsmedicine\/Antibody_cross-reaction_dynamics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa691","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T15:15:12Z","timestamp":1595517312000},"page":"229-235","source":"Crossref","is-referenced-by-count":3,"title":["Uncovering antibody cross-reaction dynamics in influenza A infections"],"prefix":"10.1093","volume":"37","author":[{"given":"Gustavo","family":"Hernandez-Mejia","sequence":"first","affiliation":[{"name":"Frankfurt Institute for Advanced Studies , 60438 Frankfurt am Main, Germany"},{"name":"Faculty of Biological Sciences, Goethe University , 60438 Frankfurt am Main, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-435X","authenticated-orcid":false,"given":"Esteban A","family":"Hernandez-Vargas","sequence":"additional","affiliation":[{"name":"Frankfurt Institute for Advanced Studies , 60438 Frankfurt am Main, Germany"},{"name":"Instituto de Matem\u00e1ticas, Universidad Nacional Autonoma de Mexico , Blv. Juriquilla 3001, 76230 Juriquilla, Quer\u00e9taro, M\u00e9xico"}]}],"member":"286","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"2023051511003410000_btaa691-B1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.3389\/fmicb.2017.01693","article-title":"A population dynamics model for clonal diversity in a germinal center","volume":"8","author":"Amitai","year":"2017","journal-title":"Front. Microbiol"},{"key":"2023051511003410000_btaa691-B2","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1038\/s41598-017-14931-7","article-title":"Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain","volume":"7","author":"Anderson","year":"2017","journal-title":"Sci. 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