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Here, we present a novel integrative web-based virtual reality (VR) system\u2014VRmol, to visualize and study molecular structures in an immersive virtual environment. Importantly, it is integrated with multiple online databases and is able to couple structure studies with associated genomic variations and drug information in a visual interface by cloud-based drug docking. VRmol thus can serve as an integrative platform to aid structure-based translational research and drug design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>VRmol is freely available (https:\/\/VRmol.net), with detailed manual and tutorial (https:\/\/VRmol.net\/docs). The code of VRmol is available as open source under the MIT license at http:\/\/github.com\/kuixu\/VRmol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btaa696","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T07:26:54Z","timestamp":1595834814000},"page":"1029-1031","source":"Crossref","is-referenced-by-count":26,"title":["VRmol: an integrative web-based virtual reality system to explore macromolecular structure"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-5479","authenticated-orcid":false,"given":"Kui","family":"Xu","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, School of Life Sciences , Beijing 100084, China"},{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"},{"name":"Tsinghua-Peking Joint Center for Life Sciences , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"},{"name":"Tsinghua-Peking Joint Center for Life Sciences , Beijing 100084, China"},{"name":"Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingle","family":"Xu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, School of Life Sciences , Beijing 100084, China"},{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlong","family":"Guo","sequence":"additional","affiliation":[{"name":"Tsinghua-Peking Joint Center for Life Sciences , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"},{"name":"Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"},{"name":"Tsinghua-Peking Joint Center for Life Sciences , Beijing 100084, China"},{"name":"Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangfeng Cliff","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Bioinformatics, School of Life Sciences , Beijing 100084, China"},{"name":"Beijing Advanced Innovation Center for Structural Biology, Beijing Frotier Research Center for Biological Structures , Beijing 100084, China"},{"name":"Tsinghua-Peking Joint Center for Life Sciences , Beijing 100084, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"2023051612160074600_btaa696-B1","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/bioinformatics\/btv285","article-title":"The SwissLipids knowledgebase for lipid biology","volume":"31","author":"Aimo","year":"2015","journal-title":"Bioinformatics"},{"key":"2023051612160074600_btaa696-B2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. 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